Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity.
Gong N, Kim D, Alameh MG, El-Mayta R, Han EL, Dwivedi G, Palanki R, Shi Q, Han X, Xue L, Xu J, Meng Z, Luo T, Figueroa-Espada CG, Weissman D, Li J, Mitchell MJ. Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity. Nat Biomed Eng. 2025 Dec; 9(12):2181-2195.