 Phosphonoacetic Acid
"Phosphonoacetic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A simple organophosphorus compound that inhibits DNA polymerase, especially in viruses and is used as an antiviral agent.
| Descriptor ID |
D010746
|
| MeSH Number(s) |
D02.241.081.018.677 D02.705.429.875
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Phosphonoacetic Acid".
Below are MeSH descriptors whose meaning is more specific than "Phosphonoacetic Acid".
This graph shows the total number of publications written about "Phosphonoacetic Acid" by people in this website by year, and whether "Phosphonoacetic Acid" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 2 | 0 | 2 | | 2004 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2011 | 1 | 1 | 2 | | 2020 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Phosphonoacetic Acid" by people in Profiles.
-
Ryan DE, Diamant-Levi T, Steinfeld I, Taussig D, Visal-Shah S, Thakker S, Lunstad BD, Kaiser RJ, McCaffrey R, Ortiz M, Townsend J, Welch WRW, Singh M, Curry B, Dellinger DJ, Bruhn L. Phosphonoacetate Modifications Enhance the Stability and Editing Yields of Guide RNAs for Cas9 Editors. Biochemistry. 2023 12 19; 62(24):3512-3520.
-
Kumar P, Caruthers MH. DNA Analogues Modified at the Nonlinking Positions of Phosphorus. Acc Chem Res. 2020 10 20; 53(10):2152-2166.
-
Ryan DE, Taussig D, Steinfeld I, Phadnis SM, Lunstad BD, Singh M, Vuong X, Okochi KD, McCaffrey R, Olesiak M, Roy S, Yung CW, Curry B, Sampson JR, Bruhn L, Dellinger DJ. Improving CRISPR-Cas specificity with chemical modifications in single-guide RNAs. Nucleic Acids Res. 2018 Jan 25; 46(2):792-803.
-
Threlfall RN, Torres AG, Krivenko A, Gait MJ, Caruthers MH. Synthesis and biological activity of phosphonoacetate- and thiophosphonoacetate-modified 2'-O-methyl oligoribonucleotides. Org Biomol Chem. 2012 Jan 28; 10(4):746-54.
-
Azarkh Y, D?lken L, Nagel M, Gilden D, Cohrs RJ. Synthesis and decay of varicella zoster virus transcripts. J Neurovirol. 2011 Jun; 17(3):281-7.
-
Yamada CM, Dellinger DJ, Caruthers MH. Synthesis and biological activity of phosphonocarboxylate DNA. Nucleosides Nucleotides Nucleic Acids. 2007; 26(6-7):539-46.
-
Dellinger DJ, Yamada CM, Caruthers MH. Oligodeoxyribonucleotide analogs functionalized with phosphonoacetate and thiophosphonoacetate diesters. Curr Protoc Nucleic Acid Chem. 2004 Oct; Chapter 4:Unit 4.24.
-
Sheehan D, Lunstad B, Yamada CM, Stell BG, Caruthers MH, Dellinger DJ. Biochemical properties of phosphonoacetate and thiophosphonoacetate oligodeoxyribonucleotides. Nucleic Acids Res. 2003 Jul 15; 31(14):4109-18.
-
Dellinger DJ, Sheehan DM, Christensen NK, Lindberg JG, Caruthers MH. Solid-phase chemical synthesis of phosphonoacetate and thiophosphonoacetate oligodeoxynucleotides. J Am Chem Soc. 2003 Jan 29; 125(4):940-50.
-
Palestine AG, Polis MA, De Smet MD, Baird BF, Falloon J, Kovacs JA, Davey RT, Zurlo JJ, Zunich KM, Davis M, et al. A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS. Ann Intern Med. 1991 Nov 01; 115(9):665-73.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|