 Diphosphonates
"Diphosphonates" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They inhibit ectopic calcification and slow down bone resorption and bone turnover. Technetium complexes of diphosphonates have been used successfully as bone scanning agents.
| Descriptor ID |
D004164
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| MeSH Number(s) |
D02.705.429.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Diphosphonates".
Below are MeSH descriptors whose meaning is more specific than "Diphosphonates".
This graph shows the total number of publications written about "Diphosphonates" by people in this website by year, and whether "Diphosphonates" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 | | 2002 | 1 | 0 | 1 | | 2003 | 3 | 0 | 3 | | 2004 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 2 | 0 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 0 | 3 | 3 | | 2010 | 2 | 1 | 3 | | 2011 | 2 | 3 | 5 | | 2012 | 3 | 2 | 5 | | 2013 | 1 | 1 | 2 | | 2014 | 2 | 0 | 2 | | 2015 | 1 | 1 | 2 | | 2016 | 4 | 0 | 4 | | 2017 | 0 | 1 | 1 | | 2018 | 2 | 0 | 2 | | 2019 | 0 | 2 | 2 | | 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Diphosphonates" by people in Profiles.
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Gralow JR, Barlow WE, Paterson AHG, M'iao JL, Lew DL, Stopeck AT, Hayes DF, Hershman DL, Schubert MM, Clemons M, Van Poznak CH, Dees EC, Ingle JN, Falkson CI, Elias AD, Messino MJ, Margolis JH, Dakhil SR, Chew HK, Dammann KZ, Abrams JS, Livingston RB, Hortobagyi GN. Phase III Randomized Trial of Bisphosphonates as Adjuvant Therapy in Breast Cancer: S0307. J Natl Cancer Inst. 2020 07 01; 112(7):698-707.
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Ferraro K, Sanchez-Reilly S. Palliative Volume Resuscitation in a Patient with Cancer and Hypercalcemia: Why Bother? J Palliat Med. 2020 06; 23(6):871-873.
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Rothman MS, Olenginski TP, Stanciu I, Krohn K, Lewiecki EM. Lessons learned with Bone Health TeleECHO: making treatment decisions when guidelines conflict. Osteoporos Int. 2019 Dec; 30(12):2401-2406.
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Anderson D, Park AJ. Prophylactic treatment of osteoporosis after SCI: promising research, but not yet indicated. Spinal Cord Ser Cases. 2019; 5:25.
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Garganta MD, Jaser SS, Lazow MA, Schoenecker JG, Cobry E, Hays SR, Simmons JH. Cyclic bisphosphonate therapy reduces pain and improves physical functioning in children with osteogenesis imperfecta. BMC Musculoskelet Disord. 2018 Sep 24; 19(1):344.
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Seider MJ, Pugh SL, Langer C, Wyatt G, Demas W, Rashtian A, Clausen CL, Derdel JD, Cleary SF, Peters CA, Ramalingam A, Clarkson JE, Tomblyn M, Rabinovitch RA, Kachnic LA, Berk LB. Randomized phase III trial to evaluate radiopharmaceuticals and zoledronic acid in the palliation of osteoblastic metastases from lung, breast, and prostate cancer: report of the NRG Oncology RTOG 0517 trial. Ann Nucl Med. 2018 Oct; 32(8):553-560.
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Hak DJ. The biology of fracture healing in osteoporosis and in the presence of anti-osteoporotic drugs. Injury. 2018 Aug; 49(8):1461-1465.
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O'Donnell C, Bloch N, Michael N, Erickson M, Garg S. Management of Scoliosis in Children with Osteogenesis Imperfecta. JBJS Rev. 2017 07; 5(7):e8.
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Khajuria DK, Vasireddi R, Trebbin M, Karasik D, Razdan R. Novel therapeutic intervention for osteoporosis prepared with strontium hydroxyapatite and zoledronic acid: In vitro and pharmacodynamic evaluation. Mater Sci Eng C Mater Biol Appl. 2017 Feb 01; 71:698-708.
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Webb NR, Jesse MK. Hip pain. Bisphosphonate-related atypical subtrochanteric femoral fracture in patient with Paget disease. Skeletal Radiol. 2016 Jun; 45(6):825-6, 853-4.
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