 Picrotoxin
"Picrotoxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.
| Descriptor ID |
D010852
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| MeSH Number(s) |
D02.455.426.392.368.367.800 D02.540.552
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Picrotoxin".
Below are MeSH descriptors whose meaning is more specific than "Picrotoxin".
This graph shows the total number of publications written about "Picrotoxin" by people in this website by year, and whether "Picrotoxin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 | | 2008 | 0 | 2 | 2 | | 2009 | 0 | 2 | 2 | | 2010 | 0 | 2 | 2 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Picrotoxin" by people in Profiles.
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Baratta MV, Leslie NR, Fallon IP, Dolzani SD, Chun LE, Tamalunas AM, Watkins LR, Maier SF. Behavioural and neural sequelae of stressor exposure are not modulated by controllability in females. Eur J Neurosci. 2018 04; 47(8):959-967.
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Yamashita PS, Spiacci A, Hassel JE, Lowry CA, Zangrossi H. Disinhibition of the rat prelimbic cortex promotes serotonergic activation of the dorsal raphe nucleus and panicolytic-like behavioral effects. J Psychopharmacol. 2017 06; 31(6):704-714.
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Thompson BM, Baratta MV, Biedenkapp JC, Rudy JW, Watkins LR, Maier SF. Activation of the infralimbic cortex in a fear context enhances extinction learning. Learn Mem. 2010 Nov; 17(11):591-9.
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Evers DM, Matta JA, Hoe HS, Zarkowsky D, Lee SH, Isaac JT, Pak DT. Plk2 attachment to NSF induces homeostatic removal of GluA2 during chronic overexcitation. Nat Neurosci. 2010 Oct; 13(10):1199-207.
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Weinberg MS, Johnson DC, Bhatt AP, Spencer RL. Medial prefrontal cortex activity can disrupt the expression of stress response habituation. Neuroscience. 2010 Jul 14; 168(3):744-56.
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Ford CP, Phillips PE, Williams JT. The time course of dopamine transmission in the ventral tegmental area. J Neurosci. 2009 Oct 21; 29(42):13344-52.
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Christianson JP, Thompson BM, Watkins LR, Maier SF. Medial prefrontal cortical activation modulates the impact of controllable and uncontrollable stressor exposure on a social exploration test of anxiety in the rat. Stress. 2009 Sep; 12(5):445-50.
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Amat J, Paul E, Watkins LR, Maier SF. Activation of the ventral medial prefrontal cortex during an uncontrollable stressor reproduces both the immediate and long-term protective effects of behavioral control. Neuroscience. 2008 Jul 17; 154(4):1178-86.
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Rozeske RR, Der-Avakian A, Bland ST, Beckley JT, Watkins LR, Maier SF. The medial prefrontal cortex regulates the differential expression of morphine-conditioned place preference following a single exposure to controllable or uncontrollable stress. Neuropsychopharmacology. 2009 Mar; 34(4):834-43.
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Jones J, Stubblefield EA, Benke TA, Staley KJ. Desynchronization of glutamate release prolongs synchronous CA3 network activity. J Neurophysiol. 2007 May; 97(5):3812-8.
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