 Dichlororibofuranosylbenzimidazole
"Dichlororibofuranosylbenzimidazole" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An RNA polymerase II transcriptional inhibitor. This compound terminates transcription prematurely by selective inhibition of RNA synthesis. It is used in research to study underlying mechanisms of cellular regulation.
| Descriptor ID |
D004004
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| MeSH Number(s) |
D13.570.800.330
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| Concept/Terms |
Dichlororibofuranosylbenzimidazole- Dichlororibofuranosylbenzimidazole
- Dichlorobenzimidazole Riboside
- Riboside, Dichlorobenzimidazole
- 5,6-Dichloro-1-beta-D-ribofuranosyl-1-H-benzimidazol
- 5,6 Dichloro 1 beta D ribofuranosyl 1 H benzimidazol
- DRB
- 5,6-Dichloro-1-beta-ribofuranosylbenzimidazole
- 5,6 Dichloro 1 beta ribofuranosylbenzimidazole
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Below are MeSH descriptors whose meaning is more general than "Dichlororibofuranosylbenzimidazole".
Below are MeSH descriptors whose meaning is more specific than "Dichlororibofuranosylbenzimidazole".
This graph shows the total number of publications written about "Dichlororibofuranosylbenzimidazole" by people in this website by year, and whether "Dichlororibofuranosylbenzimidazole" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2003 | 1 | 0 | 1 | | 2004 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 |
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Below are the most recent publications written about "Dichlororibofuranosylbenzimidazole" by people in Profiles.
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Mu?oz MJ, P?rez Santangelo MS, Paronetto MP, de la Mata M, Pelisch F, Boireau S, Glover-Cutter K, Ben-Dov C, Blaustein M, Lozano JJ, Bird G, Bentley D, Bertrand E, Kornblihtt AR. DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation. Cell. 2009 May 15; 137(4):708-20.
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Bird G, Zorio DA, Bentley DL. RNA polymerase II carboxy-terminal domain phosphorylation is required for cotranscriptional pre-mRNA splicing and 3'-end formation. Mol Cell Biol. 2004 Oct; 24(20):8963-9.
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Medlin JE, Uguen P, Taylor A, Bentley DL, Murphy S. The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3' processing of U2 snRNA. EMBO J. 2003 Feb 17; 22(4):925-34.
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Zorio DA, Bentley DL. Transcription elongation: the 'Foggy' is liftingellipsis. Curr Biol. 2001 Feb 20; 11(4):R144-6.
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Yankulov K, Yamashita K, Roy R, Egly JM, Bentley DL. The transcriptional elongation inhibitor 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole inhibits transcription factor IIH-associated protein kinase. J Biol Chem. 1995 Oct 13; 270(41):23922-5.
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Roberts S, Bentley DL. Distinct modes of transcription read through or terminate at the c-myc attenuator. EMBO J. 1992 Mar; 11(3):1085-93.
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Ribera AB, Spitzer NC. Differentiation of delayed rectifier potassium current in embryonic amphibian myocytes. Dev Biol. 1991 Mar; 144(1):119-28.
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Ribera AB, Spitzer NC. A critical period of transcription required for differentiation of the action potential of spinal neurons. Neuron. 1989 Jan; 2(1):1055-62.
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