 Luteinizing Hormone, beta Subunit
"Luteinizing Hormone, beta Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The beta subunit of luteinizing hormone. It is a 15-kDa glycopolypeptide with structure similar to the beta subunit of the placental chorionic gonadatropin (CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN) except for the additional 31 amino acids at the C-terminal of CG-beta. Full biological activity of LH requires the non-covalently bound heterodimers of an alpha and a beta subunit. Mutation of the LHB gene causes HYPOGONADISM and infertility.
| Descriptor ID |
D037101
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| MeSH Number(s) |
D06.472.699.322.576.463.500 D06.472.699.631.525.343.463.500 D12.644.548.691.525.343.463.500
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| Concept/Terms |
Luteinizing Hormone, beta Subunit- Luteinizing Hormone, beta Subunit
- Lutropin, beta Subunit
- Luteinizing Hormone, beta Chain
- Luteinizing Hormone, beta Polypeptide Chain
- Lutropin-beta
- Lutropin beta
- ICSH, beta Subunit
- LH-beta
- LH beta
- LH, beta Subunit
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Below are MeSH descriptors whose meaning is more general than "Luteinizing Hormone, beta Subunit".
- Chemicals and Drugs [D]
- Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
- Hormones [D06.472]
- Peptide Hormones [D06.472.699]
- Gonadotropins [D06.472.699.322]
- Gonadotropins, Pituitary [D06.472.699.322.576]
- Luteinizing Hormone [D06.472.699.322.576.463]
- Luteinizing Hormone, beta Subunit [D06.472.699.322.576.463.500]
- Pituitary Hormones [D06.472.699.631]
- Pituitary Hormones, Anterior [D06.472.699.631.525]
- Gonadotropins, Pituitary [D06.472.699.631.525.343]
- Luteinizing Hormone [D06.472.699.631.525.343.463]
- Luteinizing Hormone, beta Subunit [D06.472.699.631.525.343.463.500]
- Amino Acids, Peptides, and Proteins [D12]
- Peptides [D12.644]
- Peptide Hormones [D12.644.548]
- Pituitary Hormones [D12.644.548.691]
- Pituitary Hormones, Anterior [D12.644.548.691.525]
- Gonadotropins, Pituitary [D12.644.548.691.525.343]
- Luteinizing Hormone [D12.644.548.691.525.343.463]
- Luteinizing Hormone, beta Subunit [D12.644.548.691.525.343.463.500]
Below are MeSH descriptors whose meaning is more specific than "Luteinizing Hormone, beta Subunit".
This graph shows the total number of publications written about "Luteinizing Hormone, beta Subunit" by people in this website by year, and whether "Luteinizing Hormone, beta Subunit" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Luteinizing Hormone, beta Subunit" by people in Profiles.
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Zhang Z, Florez S, Gutierrez-Hartmann A, Martin JF, Amendt BA. MicroRNAs regulate pituitary development, and microRNA 26b specifically targets lymphoid enhancer factor 1 (Lef-1), which modulates pituitary transcription factor 1 (Pit-1) expression. J Biol Chem. 2010 Nov 05; 285(45):34718-28.
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Kumar TR. Functional analysis of LHbeta knockout mice. Mol Cell Endocrinol. 2007 Apr 15; 269(1-2):81-4.
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Zhang L, Kessler AE, Tsai PS. Characterization and steroidal regulation of gonadotropin beta subunits in the male leopard frog, Rana pipiens. Gen Comp Endocrinol. 2007 Jan 01; 150(1):66-74.
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Kumar TR. What have we learned about gonadotropin function from gonadotropin subunit and receptor knockout mice? Reproduction. 2005 Sep; 130(3):293-302.
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Ma X, Dong Y, Matzuk MM, Kumar TR. Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):17294-9.
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