 Auranofin
"Auranofin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.
| Descriptor ID |
D001310
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| MeSH Number(s) |
D02.691.675.249.150
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Auranofin".
Below are MeSH descriptors whose meaning is more specific than "Auranofin".
This graph shows the total number of publications written about "Auranofin" by people in this website by year, and whether "Auranofin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 0 | 1 | 1 | | 2013 | 0 | 2 | 2 |
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Below are the most recent publications written about "Auranofin" by people in Profiles.
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Go YM, Roede JR, Walker DI, Duong DM, Seyfried NT, Orr M, Liang Y, Pennell KD, Jones DP. Selective targeting of the cysteine proteome by thioredoxin and glutathione redox systems. Mol Cell Proteomics. 2013 Nov; 12(11):3285-96.
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Chandler JD, Nichols DP, Nick JA, Hondal RJ, Day BJ. Selective metabolism of hypothiocyanous acid by mammalian thioredoxin reductase promotes lung innate immunity and antioxidant defense. J Biol Chem. 2013 Jun 21; 288(25):18421-8.
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Lopert P, Day BJ, Patel M. Thioredoxin reductase deficiency potentiates oxidative stress, mitochondrial dysfunction and cell death in dopaminergic cells. PLoS One. 2012; 7(11):e50683.
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Szefler SJ. Anti-inflammatory drugs in the treatment of allergic disease. Med Clin North Am. 1992 Jul; 76(4):953-75.
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Alvarez J, Szefler SJ. Alternative therapy in severe asthma. J Asthma. 1992; 29(1):3-11.
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Wigler I, Caspi D, Lorber M, Sukenik S, Green L, Fishel B, Tishler M, Segal R, Horovitz J, Yaron M. [Oral gold for rheumatoid arthritis]. Harefuah. 1988 Jun 01; 114(11):529-33.
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Monia BP, Butt TR, Mirabelli CK, Ecker DJ, Sternberg E, Crooke ST. Induction of metallothionein is correlated with resistance to auranofin, a gold compound, in Chinese hamster ovary cells. Mol Pharmacol. 1987 Jan; 31(1):21-6.
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Crooke ST, Snyder RM, Butt TR, Ecker DJ, Allaudeen HS, Monia B, Mirabelli CK. Cellular and molecular pharmacology of auranofin and related gold complexes. Biochem Pharmacol. 1986 Oct 15; 35(20):3423-31.
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