 11-beta-Hydroxysteroid Dehydrogenase Type 2
"11-beta-Hydroxysteroid Dehydrogenase Type 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An high-affinity, NAD-dependent 11-beta-hydroxysteroid dehydrogenase that acts unidirectionally to catalyze the dehydrogenation of CORTISOL to CORTISONE. It is found predominantly in mineralocorticoid target tissues such as the KIDNEY; COLON; SWEAT GLANDS; and the PLACENTA. Absence of the enzyme leads to a fatal form of childhood hypertension termed, APPARENT MINERALOCORTICOID EXCESS SYNDROME.
| Descriptor ID |
D043209
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| MeSH Number(s) |
D08.811.682.047.436.174.600 D08.811.682.047.820.100.600
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| Concept/Terms |
11-beta-Hydroxysteroid Dehydrogenase Type 2- 11-beta-Hydroxysteroid Dehydrogenase Type 2
- 11 beta Hydroxysteroid Dehydrogenase Type 2
- 11beta-Hydroxysteroid Dehydrogenase Type 2
- 11beta Hydroxysteroid Dehydrogenase Type 2
- 11beta-HSD2
- 11beta-HSD2 Reductase
- 11 beta-HSD2
- 11 beta-Hydroxysteroid Dehydrogenase Type 2
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Below are MeSH descriptors whose meaning is more general than "11-beta-Hydroxysteroid Dehydrogenase Type 2".
Below are MeSH descriptors whose meaning is more specific than "11-beta-Hydroxysteroid Dehydrogenase Type 2".
This graph shows the total number of publications written about "11-beta-Hydroxysteroid Dehydrogenase Type 2" by people in this website by year, and whether "11-beta-Hydroxysteroid Dehydrogenase Type 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2009 | 0 | 1 | 1 | | 2013 | 0 | 1 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "11-beta-Hydroxysteroid Dehydrogenase Type 2" by people in Profiles.
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Theodoridi A, Dinarello A, Badenetti L, Pavlidis M, Dalla Valle L, Tsalafouta A. Knockout of the hsd11b2 Gene Extends the Cortisol Stress Response in Both Zebrafish Larvae and Adults. Int J Mol Sci. 2021 Nov 20; 22(22).
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Keleher MR, Erickson K, Smith HA, Kechris KJ, Yang IV, Dabelea D, Friedman JE, Boyle KE, Jansson T. Placental Insulin/IGF-1 Signaling, PGC-1a, and Inflammatory Pathways Are Associated With Metabolic Outcomes at 4-6 Years of Age: The ECHO Healthy Start Cohort. Diabetes. 2021 03; 70(3):745-751.
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Jansson T, Powell TL. Role of placental nutrient sensing in developmental programming. Clin Obstet Gynecol. 2013 Sep; 56(3):591-601.
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Vaughan OR, Sferruzzi-Perri AN, Fowden AL. Maternal corticosterone regulates nutrient allocation to fetal growth in mice. J Physiol. 2012 Nov 01; 590(21):5529-40.
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Dovio A, Sartori ML, De Francia S, Mussino S, Perotti P, Saba L, Abbadessa G, Racca S, Angeli A. Differential expression of determinants of glucocorticoid sensitivity in androgen-dependent and androgen-independent human prostate cancer cell lines. J Steroid Biochem Mol Biol. 2009 Aug; 116(1-2):29-36.
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Pankevich DE, Mueller BR, Brockel B, Bale TL. Prenatal stress programming of offspring feeding behavior and energy balance begins early in pregnancy. Physiol Behav. 2009 Aug 04; 98(1-2):94-102.
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