 Protein S Deficiency
"Protein S Deficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
| Descriptor ID |
D018455
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| MeSH Number(s) |
C15.378.100.800 C15.378.147.890 C15.378.925.800
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| Concept/Terms |
Protein S Deficiency- Protein S Deficiency
- Hereditary Thrombophilia Due To Protein S Deficiency
- Deficiency, Protein S
- Deficiencies, Protein S
- Protein S Deficiencies
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Below are MeSH descriptors whose meaning is more general than "Protein S Deficiency".
Below are MeSH descriptors whose meaning is more specific than "Protein S Deficiency".
This graph shows the total number of publications written about "Protein S Deficiency" by people in this website by year, and whether "Protein S Deficiency" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 1995 | 1 | 1 | 2 | | 1996 | 2 | 0 | 2 | | 2004 | 0 | 1 | 1 |
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Below are the most recent publications written about "Protein S Deficiency" by people in Profiles.
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Hasan S, Elbedawi M, Castro O, Gladwin M, Palestine A. Central retinal vein occlusion in sickle cell disease. South Med J. 2004 Feb; 97(2):202-4.
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Lefkowitz JB, Clarke SH, Barbour LA. Comparison of protein S functional and antigenic assays in normal pregnancy. Am J Obstet Gynecol. 1996 Sep; 175(3 Pt 1):657-60.
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Manco-Johnson MJ, Nuss R, Key N, Moertel C, Jacobson L, Meech S, Weinberg A, Lefkowitz J. Lupus anticoagulant and protein S deficiency in children with postvaricella purpura fulminans or thrombosis. J Pediatr. 1996 Mar; 128(3):319-23.
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Galan HL, McDowell AB, Johnson PR, Kuehl TJ, Knight AB. Puerperal cerebral venous thrombosis associated with decreased free protein S: a case report. J Reprod Med. 1995 Dec; 40(12):859-62.
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Nuss R, Hays T, Manco-Johnson M. Childhood thrombosis. Pediatrics. 1995 Aug; 96(2 Pt 1):291-4.
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Hassell KL, Kressin DC, Neumann A, Ellison R, Marlar RA. Correlation of antiphospholipid antibodies and protein S deficiency with thrombosis in HIV-infected men. Blood Coagul Fibrinolysis. 1994 Aug; 5(4):455-62.
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