 Protein C Deficiency
"Protein C Deficiency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An absence or deficiency in PROTEIN C which leads to impaired regulation of blood coagulation. It is associated with an increased risk of severe or premature thrombosis. (Stedman's Med. Dict., 26th ed.)
| Descriptor ID |
D020151
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| MeSH Number(s) |
C15.378.100.100.690 C15.378.147.880 C15.378.925.795 C16.320.099.690
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| Concept/Terms |
Protein C Deficiency- Protein C Deficiency
- Hereditary Thrombophilia Due To Protein C Deficiency
- Deficiency, Protein C
- Deficiencies, Protein C
- Protein C Deficiencies
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Below are MeSH descriptors whose meaning is more general than "Protein C Deficiency".
Below are MeSH descriptors whose meaning is more specific than "Protein C Deficiency".
This graph shows the total number of publications written about "Protein C Deficiency" by people in this website by year, and whether "Protein C Deficiency" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 2004 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2012 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Protein C Deficiency" by people in Profiles.
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Manco-Johnson M, Brons P, Knoebl P, Wang M, Siffel C, Turecek PL, Gazda HT. Real-world use of protein C concentrate for the treatment of patients with protein C deficiency: an international registry. J Thromb Haemost. 2025 Nov; 23(11):3569-3577.
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Manco-Johnson MJ, Bomgaars L, Palascak J, Shapiro A, Geil J, Fritsch S, Pavlova BG, Gelmont D. Efficacy and safety of protein C concentrate to treat purpura fulminans and thromboembolic events in severe congenital protein C deficiency. Thromb Haemost. 2016 07 04; 116(1):58-68.
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Ranieri VM, Thompson BT, Barie PS, Dhainaut JF, Douglas IS, Finfer S, Gårdlund B, Marshall JC, Rhodes A, Artigas A, Payen D, Tenhunen J, Al-Khalidi HR, Thompson V, Janes J, Macias WL, Vangerow B, Williams MD. Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med. 2012 May 31; 366(22):2055-64.
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Goldenberg NA, Manco-Johnson MJ. Protein C deficiency. Haemophilia. 2008 Nov; 14(6):1214-21.
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Manco-Johnson MJ. Etiopathogenesis of pediatric thrombosis. Hematology. 2005; 10 Suppl 1:167-70.
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Manco-Johnson MJ, Knapp-Clevenger R. Activated protein C concentrate reverses purpura fulminans in severe genetic protein C deficiency. J Pediatr Hematol Oncol. 2004 Jan; 26(1):25-7.
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Petäjä J, Manco-Johnson MJ. Protein C pathway in infants and children. Semin Thromb Hemost. 2003 Aug; 29(4):349-62.
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Morasch MD, Ebaugh JL, Chiou AC, Matsumura JS, Pearce WH, Yao JS. Mesenteric venous thrombosis: a changing clinical entity. J Vasc Surg. 2001 Oct; 34(4):680-4.
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Zimbelman J, Lefkowitz J, Schaeffer C, Hays T, Manco-Johnson M, Manhalter C, Nuss R. Unusual complications of warfarin therapy: skin necrosis and priapism. J Pediatr. 2000 Aug; 137(2):266-8.
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Nuss R, Hays T, Manco-Johnson M. Childhood thrombosis. Pediatrics. 1995 Aug; 96(2 Pt 1):291-4.
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