 RGS Proteins
"RGS Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A large family of evolutionarily conserved proteins that function as negative regulators of HETEROTRIMERIC GTP-BINDING PROTEINS. RGS PROTEINS act by increasing the GTPase activity of the G alpha subunit of a heterotrimeric GTP-binding protein, causing it to revert to its inactive (GDP-bound) form.
| Descriptor ID |
D020710
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| MeSH Number(s) |
D12.644.360.325.150.750 D12.776.476.325.150.750
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| Concept/Terms |
RGS Proteins- RGS Proteins
- Regulators of G-Protein Signaling Proteins
- Regulators of G Protein Signaling Proteins
- RGS Protein (G-Protein Signaling)
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Below are MeSH descriptors whose meaning is more general than "RGS Proteins".
Below are MeSH descriptors whose meaning is more specific than "RGS Proteins".
This graph shows the total number of publications written about "RGS Proteins" by people in this website by year, and whether "RGS Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 | | 2008 | 1 | 0 | 1 | | 2009 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2011 | 3 | 0 | 3 | | 2012 | 1 | 0 | 1 | | 2017 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 | | 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "RGS Proteins" by people in Profiles.
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Keramati AR, Chen MH, Rodriguez BAT, Yanek LR, Bhan A, Gaynor BJ, Ryan K, Brody JA, Zhong X, Wei Q, Kammers K, Kanchan K, Iyer K, Kowalski MH, Pitsillides AN, Cupples LA, Li B, Schlaeger TM, Shuldiner AR, O'Connell JR, Ruczinski I, Mitchell BD, Faraday N, Taub MA, Becker LC, Lewis JP, Mathias RA, Johnson AD. Genome sequencing unveils a regulatory landscape of platelet reactivity. Nat Commun. 2021 Jun 15; 12(1):3626.
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Li F, Hu D, Dieter C, Ansong C, Sussel L, Orr G. Single Molecule-Based fliFISH Validates Radial and Heterogeneous Gene Expression Patterns in Pancreatic Islet ?-Cells. Diabetes. 2021 05; 70(5):1117-1122.
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Schroer AB, Branyan KW, Gross JD, Chantler PD, Kimple AJ, Vandenbeuch A, Siderovski DP. The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21). Chem Senses. 2021 01 01; 46.
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Schroer AB, Gross JD, Kaski SW, Wix K, Siderovski DP, Vandenbeuch A, Setola V. Development of Full Sweet, Umami, and Bitter Taste Responsiveness Requires Regulator of G protein Signaling-21 (RGS21). Chem Senses. 2018 05 23; 43(5):367-378.
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Qutob N, Masuho I, Alon M, Emmanuel R, Cohen I, Di Pizio A, Madore J, Elkahloun A, Ziv T, Levy R, Gartner JJ, Hill VK, Lin JC, Hevroni Y, Greenberg P, Brodezki A, Rosenberg SA, Kosloff M, Hayward NK, Admon A, Niv MY, Scolyer RA, Martemyanov KA, Samuels Y. RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells. Sci Rep. 2018 01 12; 8(1):653.
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Kanai SM, Edwards AJ, Rurik JG, Osei-Owusu P, Blumer KJ. Proteolytic degradation of regulator of G protein signaling 2 facilitates temporal regulation of Gq/11 signaling and vascular contraction. J Biol Chem. 2017 11 24; 292(47):19266-19278.
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Scherer SL, Cain MD, Kanai SM, Kaltenbronn KM, Blumer KJ. Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Ga13. J Biol Chem. 2017 06 16; 292(24):9906-9918.
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Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham CJ, Grobe JL, Faraci FM, England SK, Sigmund CD. PPAR? regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. Circ Res. 2012 Nov 09; 111(11):1446-58.
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Gospe SM, Baker SA, Kessler C, Brucato MF, Winter JR, Burns ME, Arshavsky VY. Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors. J Neurosci. 2011 Oct 12; 31(41):14660-8.
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Kosloff M, Travis AM, Bosch DE, Siderovski DP, Arshavsky VY. Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions. Nat Struct Mol Biol. 2011 Jun 19; 18(7):846-53.
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