 Peptide Chain Initiation, Translational
"Peptide Chain Initiation, Translational" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A process of GENETIC TRANSLATION whereby the formation of a peptide chain is started. It includes assembly of the RIBOSOME components, the MESSENGER RNA coding for the polypeptide to be made, INITIATOR TRNA, and PEPTIDE INITIATION FACTORS; and placement of the first amino acid in the peptide chain. The details and components of this process are unique for prokaryotic protein biosynthesis and eukaryotic protein biosynthesis.
| Descriptor ID |
D010442
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| MeSH Number(s) |
G02.111.660.871.650 G03.734.871.650
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| Concept/Terms |
Peptide Chain Initiation, Translational- Peptide Chain Initiation, Translational
- Chain Initiation, Peptide, Translational
- Protein Chain Initiation, Translational
- Protein Translation Initiation
- Translation Initiation, Protein
- Initiation, Protein Translation
- Protein Biosynthesis Initiation
- Biosynthesis Initiation, Protein
- Initiation, Protein Biosynthesis
- Translation Initiation, Genetic
- Genetic Translation Initiation
- Initiation, Genetic Translation
- Translational Peptide Chain Initiation
- Translational Initiation, Protein
- Initiation, Protein Translational
- Protein Translational Initiation
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Below are MeSH descriptors whose meaning is more general than "Peptide Chain Initiation, Translational".
Below are MeSH descriptors whose meaning is more specific than "Peptide Chain Initiation, Translational".
This graph shows the total number of publications written about "Peptide Chain Initiation, Translational" by people in this website by year, and whether "Peptide Chain Initiation, Translational" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 2001 | 2 | 0 | 2 | | 2002 | 1 | 0 | 1 | | 2007 | 1 | 0 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 2 | 1 | 3 | | 2011 | 2 | 0 | 2 | | 2012 | 2 | 1 | 3 | | 2013 | 1 | 0 | 1 | | 2015 | 0 | 2 | 2 | | 2016 | 2 | 1 | 3 | | 2021 | 0 | 1 | 1 | | 2024 | 1 | 0 | 1 | | 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Peptide Chain Initiation, Translational" by people in Profiles.
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Sherlock ME, Langeberg CJ, Segar KE, Kieft JS. A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions. Cell Rep. 2025 02 25; 44(2):115236.
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Gentry RC, Ide NA, Comunale VM, Hartwick EW, Kinz-Thompson CD, Gonzalez RL. The mechanism of mRNA cap recognition. Nature. 2025 Jan; 637(8046):736-743.
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Ripin N, Parker R. Are stress granules the RNA analogs of misfolded protein aggregates? RNA. 2022 01; 28(1):67-75.
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Child JR, Chen Q, Reid DW, Jagannathan S, Nicchitta CV. Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules. RNA. 2021 10; 27(10):1241-1256.
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Abaeva IS, Vicens Q, Bochler A, Soufari H, Simonetti A, Pestova TV, Hashem Y, Hellen CUT. The Halastavi ?rva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism. Cell Rep. 2020 12 08; 33(10):108476.
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Tauber D, Parker R. 15-Deoxy-?12,14-prostaglandin J2 promotes phosphorylation of eukaryotic initiation factor 2a and activates the integrated stress response. J Biol Chem. 2019 04 19; 294(16):6344-6352.
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Jaafar ZA, Oguro A, Nakamura Y, Kieft JS. Translation initiation by the hepatitis C virus IRES requires eIF1A and ribosomal complex remodeling. Elife. 2016 12 23; 5.
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Hussain T, Ll?cer JL, Wimberly BT, Kieft JS, Ramakrishnan V. Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation. Cell. 2016 Sep 22; 167(1):133-144.e13.
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Wheeler JR, Matheny T, Jain S, Abrisch R, Parker R. Distinct stages in stress granule assembly and disassembly. Elife. 2016 09 07; 5.
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Martin F, M?n?tret JF, Simonetti A, Myasnikov AG, Vicens Q, Prongidi-Fix L, Natchiar SK, Klaholz BP, Eriani G. Ribosomal 18S rRNA base pairs with mRNA during eukaryotic translation initiation. Nat Commun. 2016 08 24; 7:12622.
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