 Proof of Concept Study
"Proof of Concept Study" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An empirical investigation which pertains to the development of prototypes or models that demonstrate the feasibility of novel concepts, ideas, principles, schema or their practical application.
| Descriptor ID |
D000075082
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| MeSH Number(s) |
H01.770.644.578
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| Concept/Terms |
Proof of Concept Study- Proof of Concept Study
- Concept Study Proof
- Study Proof, Concept
- Proof of Concept Investigation
- Concept Investigation Proof
- Investigation Proof, Concept
- Proof of Concept Research
- Concept Research Proof
- Concept Research Proofs
- Research Proof, Concept
- Proof of Concept Testing
- Concept Testing Proof
- Concept Testing Proofs
- Testing Proof, Concept
- Testing Proofs, Concept
- Proof of Concept Experiment
- Concept Experiment Proof
- Concept Experiment Proofs
- Experiment Proof, Concept
- Proof of Concept Approach
- Approach Proof, Concept
- Approach Proofs, Concept
- Concept Approach Proof
- Concept Approach Proofs
- Proof of Concept Studies
Proof of Concept Prototype- Proof of Concept Prototype
- Concept Prototype Proof
- Concept Prototype Proofs
- Prototype Proof, Concept
- Proof of Concept Model
- Concept Model Proof
- Concept Model Proofs
- Model Proof, Concept
Proof of Concept Evaluation- Proof of Concept Evaluation
- Concept Evaluation Proof
- Concept Evaluation Proofs
- Evaluation Proof, Concept
- Proof of Concept Demonstration
- Concept Demonstration Proof
- Demonstration Proof, Concept
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Below are MeSH descriptors whose meaning is more general than "Proof of Concept Study".
Below are MeSH descriptors whose meaning is more specific than "Proof of Concept Study".
This graph shows the total number of publications written about "Proof of Concept Study" by people in this website by year, and whether "Proof of Concept Study" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2016 | 0 | 2 | 2 | | 2017 | 0 | 2 | 2 | | 2018 | 0 | 6 | 6 | | 2019 | 1 | 9 | 10 | | 2020 | 0 | 10 | 10 | | 2021 | 0 | 7 | 7 | | 2022 | 0 | 1 | 1 | | 2024 | 2 | 7 | 9 | | 2025 | 0 | 5 | 5 |
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Below are the most recent publications written about "Proof of Concept Study" by people in Profiles.
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Tamura S, Nelson AD, Spratt PWE, Hamada EC, Zhou X, Kyoung H, Li Z, Arnould C, Barskyi V, Krupkin B, Young K, Zhao J, Holden SS, Sahagun A, Keeshen CM, Lu C, Ben-Shalom R, Taloma SE, Schamiloglu S, Li YC, Min L, Jenkins PM, Pan JQ, Paz JT, Sanders SJ, Matharu N, Ahituv N, Bender KJ. CRISPR activation for SCN2A-related neurodevelopmental disorders. Nature. 2025 Oct; 646(8086):983-991.
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Hogue T, Das P, Reczek S, Hampton-Marcell J, Ford Y, Raval D, Carroll I, Cook MD. Effect of Acute Gut Butyrate Delivery on Blood Pressure in Black Individuals With Hypertension: A Proof-of-Concept Randomized Controlled Study. J Am Heart Assoc. 2025 Sep 02; 14(17):e039759.
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Kuehl M, Okabayashi Y, Wong MN, Gernhold L, Gut G, Kaiser N, Schwerk M, Gräfe SK, Ma FY, Tanevski J, Schäfer PSL, Mezher S, Sarabia Del Castillo J, Goldbeck-Strieder T, Zolotareva O, Hartung M, Delgado Chaves FM, Klinkert L, Gnirck AC, Spehr M, Fleck D, Joodaki M, Parra V, Shaigan M, Diebold M, Prinz M, Kranz J, Kux JM, Braun F, Kretz O, Wu H, Grahammer F, Heins S, Zimmermann M, Haas F, Kylies D, Wanner N, Czogalla J, Dumoulin B, Zolotarev N, Lindenmeyer M, Karlson P, Nyengaard JR, Sebode M, Weidemann S, Wiech T, Groene HJ, Tomas NM, Meyer-Schwesinger C, Kuppe C, Kramann R, Karras A, Bruneval P, Tharaux PL, Pastene D, Yard B, Schaub JA, McCown PJ, Pyle L, Choi YJ, Yokoo T, Baumbach J, Sáez PJ, Costa I, Turner JE, Hodgin JB, Saez-Rodriguez J, Huber TB, Bjornstad P, Kretzler M, Lenoir O, Nikolic-Paterson DJ, Pelkmans L, Bonn S, Puelles VG. Pathology-oriented multiplexing enables integrative disease mapping. Nature. 2025 Aug; 644(8076):516-526.
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Forbes E, Lattanzio L, Hardin K, Quiller L, Amara AW, Seeberger LC, Buard I. Neurologic Music Therapy for Fine Motor Recovery in Huntington's Disease: A Proof-of-Concept Magnetoencephalography Evaluation. NeuroRehabilitation. 2025 Aug; 57(1):135-140.
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O'Malley SS, Miranda R, Book SW, Chun TH, Liss T, Malcolm RJ, Muvvala SB, Padovano HT, Schacht JP, Blackburn B, Diamond I, Ransom J, Ryan ML, Falk DE, Litten RZ. Preliminary effects of oral ANS-6637, an ALDH2 inhibitor, on cue-induced craving, safety and alcohol consumption among adults with alcohol use disorder: a proof-of-concept, randomized, human laboratory trial. Alcohol Alcohol. 2025 Jan 19; 60(2).
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Smits JAJ, Abramowitz JS, Anderson RA, Arch JJ, Badeja D, Barzilay S, Belanger AN, Borchert T, Bryant E, Burger AS, Dixon LJ, Dutcher CD, Fitzgerald HE, Graham BM, Haberkamp A, Hofmann SG, Hoyer J, Huppert JD, Johnson D, Kabha BQ, Kirk A, Margraf J, McEvoy PM, McSpadden B, Newby J, Otto MW, Papini S, Parsons EM, Pittig A, Pittig R, Rief W, Schaumburg S, Timpano KR, Waltemate L, Wannemüller A, Weise C. Exposure therapy consortium: Outcomes of the proof-of-principle study. J Anxiety Disord. 2025 Jan; 109:102962.
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Brink L, Romero RA, Coombs L, Tilkin M, Mazaheri S, Gichoya J, Zaiman Z, Trivedi H, Medina A, Bizzo BC, Chang K, Kalpathy-Cramer J, Kalra MK, Astuto B, Ramirez C, Majumdar S, Lee AY, Lee CI, Cross NM, Chen PH, Ciancibello M, Chiunda A, Nachand D, Shah C, Wald C. Multi-Institutional Evaluation and Training of Breast Density Classification AI Algorithm Using ACR Connect and AI-LAB. J Am Coll Radiol. 2025 Feb; 22(2):211-219.
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Berman T, Cushing C, Manuel S, Vachon-Presseau E, Cortese A, Kawato M, Woo CW, Wager TD, Lau H, Roy M, Taschereau-Dumouchel V. Modulating subjective pain perception with decoded Montreal Neurological Institute-space neurofeedback: a proof-of-concept study. Philos Trans R Soc Lond B Biol Sci. 2024 Dec 02; 379(1915):20230082.
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Hampson HE, Li S, Walker DI, Wang H, Jia Q, Rock S, Costello E, Bjornstad P, Pyle L, Nelson J, Gilliland FD, Chen Z, Aung M, Chatzi L, Conti DV, Alderete TL, Goodrich JA. The potential mediating role of the gut microbiome and metabolites in the association between PFAS and kidney function in young adults: A proof-of-concept study. Sci Total Environ. 2024 Dec 01; 954:176519.
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Hammond JB, Tillotson M, Yoon Y, Meza Monge K, Esch EM, Madura JA, Pratap A, Winocour J, Mathes DW, Kaoutzanis C. Metabolic Bridge Therapy before Microvascular Breast Reconstruction in Morbidly Obese Patients: A Proof-of-Concept Risk Analysis. Plast Reconstr Surg. 2025 May 01; 155(5):753-760.
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