 S100 Calcium-Binding Protein A4
"S100 Calcium-Binding Protein A4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An S100 protein characterized by four helix bundles that form N- and C-terminal EF HAND MOTIFS. It functions as a homodimer and interacts with both intracellular and extracellular signaling proteins. Aberrant S100A4 activity is associated with NEOPLASM METASTASIS; FIBROSIS; and RHEUMATOID ARTHRITIS.
| Descriptor ID |
D000071999
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| MeSH Number(s) |
D12.776.157.125.750.813
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| Concept/Terms |
S100 Calcium-Binding Protein A4- S100 Calcium-Binding Protein A4
- S100 Calcium Binding Protein A4
- Metastasin Protein
- Placental Calcium-Binding Protein
- Calcium-Binding Protein, Placental
- Placental Calcium Binding Protein
- Calvasculin Protein
- Fibroblast-Specific Protein 1
- Fibroblast Specific Protein 1
- S100A4 Protein
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Below are MeSH descriptors whose meaning is more general than "S100 Calcium-Binding Protein A4".
Below are MeSH descriptors whose meaning is more specific than "S100 Calcium-Binding Protein A4".
This graph shows the total number of publications written about "S100 Calcium-Binding Protein A4" by people in this website by year, and whether "S100 Calcium-Binding Protein A4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2009 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "S100 Calcium-Binding Protein A4" by people in Profiles.
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Firl CEM, Halushka M, Fraser N, Masson M, Cuneo BF, Saxena A, Clancy R, Buyon J. Contribution of S100A4-expressing fibroblasts to anti-SSA/Ro-associated atrioventricular nodal calcification and soluble S100A4 as a biomarker of clinical severity. Front Immunol. 2023; 14:1114808.
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Xia H, Herrera J, Smith K, Yang L, Gilbertsen A, Benyumov A, Racila E, Bitterman PB, Henke CA. Hyaluronan/CD44 axis regulates S100A4-mediated mesenchymal progenitor cell fibrogenicity in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2021 05 01; 320(5):L926-L941.
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Xia H, Gilbertsen A, Herrera J, Racila E, Smith K, Peterson M, Griffin T, Benyumov A, Yang L, Bitterman PB, Henke CA. Calcium-binding protein S100A4 confers mesenchymal progenitor cell fibrogenicity in idiopathic pulmonary fibrosis. J Clin Invest. 2017 Jun 30; 127(7):2586-2597.
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Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, Acharya A, Smith CL, Tallquist MD, Neilson EG, Hill JA, Bassel-Duby R, Olson EN. Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature. 2012 May 13; 485(7400):599-604.
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Pandit KV, Corcoran D, Yousef H, Yarlagadda M, Tzouvelekis A, Gibson KF, Konishi K, Yousem SA, Singh M, Handley D, Richards T, Selman M, Watkins SC, Pardo A, Ben-Yehudah A, Bouros D, Eickelberg O, Ray P, Benos PV, Kaminski N. Inhibition and role of let-7d in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2010 Jul 15; 182(2):220-9.
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Frid MG, Li M, Gnanasekharan M, Burke DL, Fragoso M, Strassheim D, Sylman JL, Stenmark KR. Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall. Am J Physiol Lung Cell Mol Physiol. 2009 Dec; 297(6):L1059-72.
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Peng T, Zamanian R, Krowka MJ, Benza RL, Roberts KE, Taichman DB, Rybak D, Trotter JF, Brown RS, Fallon MB, Kawut SM. Plasma levels of S100A4 in portopulmonary hypertension. Biomarkers. 2009 May; 14(3):156-60.
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Rivard CJ, Brown LM, Almeida NE, Maunsbach AB, Pihakaski-Maunsbach K, Andres-Hernando A, Capasso JM, Berl T. Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive response. J Biol Chem. 2007 Mar 02; 282(9):6644-52.
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