 ADAM17 Protein
"ADAM17 Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.
| Descriptor ID |
D000072198
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| MeSH Number(s) |
D08.811.277.656.675.374.102.375 D09.400.430.500.375 D12.776.395.033.375
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| Concept/Terms |
ADAM17 Protein- ADAM17 Protein
- TACE (Enzyme)
- TNF-alpha Converting Enzyme
- TNF alpha Converting Enzyme
- Tumor Necrosis Factor Alpha Convertase
- ADAM-17
- Tumor Necrosis Factor-alpha Converting Enzyme
- Tumor Necrosis Factor alpha Converting Enzyme
- TNF-alpha Convertase
- Convertase, TNF-alpha
- TNF alpha Convertase
- CD156b Antigen
- Antigen, CD156b
- ADAM-17 Protein
- ADAM 17 Protein
- Disintegrin and Metalloproteinase Domain-Containing Protein 17
- Disintegrin and Metalloproteinase Domain Containing Protein 17
- TACA (Enzyme)
- Tumor Necrosis Factor-alpha Convertase
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Below are MeSH descriptors whose meaning is more general than "ADAM17 Protein".
Below are MeSH descriptors whose meaning is more specific than "ADAM17 Protein".
This graph shows the total number of publications written about "ADAM17 Protein" by people in this website by year, and whether "ADAM17 Protein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2005 | 0 | 2 | 2 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 3 | 3 | | 2008 | 0 | 3 | 3 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 2 | 2 | | 2012 | 0 | 1 | 1 | | 2013 | 0 | 3 | 3 | | 2015 | 0 | 2 | 2 | | 2016 | 1 | 0 | 1 | | 2017 | 0 | 2 | 2 | | 2018 | 1 | 0 | 1 | | 2020 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 | | 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "ADAM17 Protein" by people in Profiles.
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Toyoda H, Kuramasu A, Hosonuma M, Murayama M, Narikawa Y, Isobe J, Baba Y, Tajima K, Funayama E, Shida M, Maruyama Y, Sasaki A, Hirasawa Y, Tsurui T, Ariizumi H, Ishiguro T, Suzuki R, Kobayashi S, Horiike A, Hida N, Sambe T, Nobe K, Wada S, Kobayashi H, Tsuji M, Kobayashi S, Tsunoda T, Kudo Y, Kiuchi Y, Yoshimura K. MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2DLow T cells. Sci Rep. 2024 10 08; 14(1):23401.
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Xiao W, Pinilla-Baquero A, Faulkner J, Song X, Prabhakar P, Qiu H, Moremen KW, Ludwig A, Dempsey PJ, Azadi P, Wang L. Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis. Sci Rep. 2022 03 14; 12(1):4352.
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Bunker EN, Wheeler GE, Chapnick DA, Liu X. Suppression of a-catenin and adherens junctions enhances epithelial cell proliferation and motility via TACE-mediated TGF-a autocrine/paracrine signaling. Mol Biol Cell. 2021 02 15; 32(4):348-361.
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Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Kn?sel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S. ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling. J Exp Med. 2018 04 02; 215(4):1205-1225.
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Kim J, Elias A, Lee T, Maurel P, Kim HA. Tissue Inhibitor of Metalloproteinase-3 Promotes Schwann Cell Myelination. ASN Neuro. 2017 Nov-Dec; 9(6):1759091417745425.
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Serban KA, Petrusca DN, Mikosz A, Poirier C, Lockett AD, Saint L, Justice MJ, Twigg HL, Campos MA, Petrache I. Alpha-1 antitrypsin supplementation improves alveolar macrophages efferocytosis and phagocytosis following cigarette smoke exposure. PLoS One. 2017; 12(4):e0176073.
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Capone C, Dabertrand F, Baron-Menguy C, Chalaris A, Ghezali L, Domenga-Denier V, Schmidt S, Huneau C, Rose-John S, Nelson MT, Joutel A. Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics. Elife. 2016 08 01; 5.
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Feng Y, Tsai YH, Xiao W, Ralls MW, Stoeck A, Wilson CL, Raines EW, Teitelbaum DH, Dempsey PJ. Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Mol Cell Biol. 2015 Nov; 35(21):3604-21.
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Bandsma RH, van Goor H, Yourshaw M, Horlings RK, Jonkman MF, Sch?lvinck EH, Karrenbeld A, Scheenstra R, K?mhoff M, Rump P, Koopman-Keemink Y, Nelson SF, Escher JC, Cutz E, Mart?n MG. Loss of ADAM17 is associated with severe multiorgan dysfunction. Hum Pathol. 2015 Jun; 46(6):923-8.
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Chapnick DA, Bunker E, Liu X. A biosensor for the activity of the "sheddase" TACE (ADAM17) reveals novel and cell type-specific mechanisms of TACE activation. Sci Signal. 2015 Feb 24; 8(365):rs1.
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