 Endophenotypes
"Endophenotypes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Measurable biological (physiological, biochemical, and anatomical features), behavioral (psychometric pattern) or cognitive markers that are found more often in individuals with a disease than in the general population. Because many endophenotypes are present before the disease onset and in individuals with heritable risk for disease such as unaffected family members, they can be used to help diagnose and search for causative genes.
| Descriptor ID |
D058068
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| MeSH Number(s) |
G05.695.224
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Endophenotypes".
Below are MeSH descriptors whose meaning is more specific than "Endophenotypes".
This graph shows the total number of publications written about "Endophenotypes" by people in this website by year, and whether "Endophenotypes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 1 | 2 | | 2013 | 2 | 0 | 2 | | 2014 | 4 | 3 | 7 | | 2015 | 4 | 2 | 6 | | 2016 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Endophenotypes" by people in Profiles.
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Arnatkeviciute A, Lemire M, Morrison C, Mooney M, Ryabinin P, Roslin NM, Nikolas M, Coxon J, Tiego J, Hawi Z, Fornito A, Henrik W, Martinot JL, Martinot MP, Artiges E, Garavan H, Nigg J, Friedman NP, Burton C, Schachar R, Crosbie J, Bellgrove MA. Trans-ancestry meta-analysis of genome wide association studies of inhibitory control. Mol Psychiatry. 2023 Oct; 28(10):4175-4184.
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Nguyen KT, Gates CA, Hassell JE, Foxx CL, Salazar SN, Luthens AK, Arnold AL, Elam BL, Elsayed AI, Leblanc M, Adams SC, Lowry CA, Reuter JD. Evaluation of the effects of altitude on biological signatures of inflammation and anxiety- and depressive-like behavioral responses. Prog Neuropsychopharmacol Biol Psychiatry. 2021 12 20; 111:110331.
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Kent JS, Caligiuri MP, Skorheim MK, Lano TJ, Mittal VA, Sponheim SR. Instrument-based assessment of motor function yields no evidence of dyskinesia in adult first-degree biological relatives of individuals with schizophrenia and schizoaffective disorder. Psychiatry Res. 2019 02; 272:135-140.
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Petersen H, Vazquez Guillamet R, Meek P, Sood A, Tesfaigzi Y. Early Endotyping: A Chance for Intervention in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol. 2018 07; 59(1):13-17.
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Rubenstein E, Wiggins LD, Schieve LA, Bradley C, DiGuiseppi C, Moody E, Pandey J, Pretzel RE, Howard AG, Olshan AF, Pence BW, Daniels J. Associations between parental broader autism phenotype and child autism spectrum disorder phenotype in the Study to Explore Early Development. Autism. 2019 02; 23(2):436-448.
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Swerdlow NR, Light GA, Thomas ML, Sprock J, Calkins ME, Green MF, Greenwood TA, Gur RE, Gur RC, Lazzeroni LC, Nuechterlein KH, Radant AD, Seidman LJ, Siever LJ, Silverman JM, Stone WS, Sugar CA, Tsuang DW, Tsuang MT, Turetsky BI, Braff DL. Deficient prepulse inhibition in schizophrenia in a multi-site cohort: Internal replication and extension. Schizophr Res. 2018 08; 198:6-15.
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Liu M, Malone SM, Vaidyanathan U, Keller MC, Abecasis G, McGue M, Iacono WG, Vrieze SI. Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci. Psychol Med. 2017 Apr; 47(6):1116-1125.
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Iacono WG, Malone SM, Vrieze SI. Endophenotype best practices. Int J Psychophysiol. 2017 01; 111:115-144.
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Earls HA, Curran T, Mittal V. A Meta-analytic Review of Auditory Event-Related Potential Components as Endophenotypes for Schizophrenia: Perspectives From First-Degree Relatives. Schizophr Bull. 2016 11; 42(6):1504-1516.
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Millard SP, Shofer J, Braff D, Calkins M, Cadenhead K, Freedman R, Green MF, Greenwood TA, Gur R, Gur R, Lazzeroni LC, Light GA, Olincy A, Nuechterlein K, Seidman L, Siever L, Silverman J, Stone WS, Sprock J, Sugar CA, Swerdlow NR, Tsuang M, Turetsky B, Radant A, Tsuang DW. Prioritizing schizophrenia endophenotypes for future genetic studies: An example using data from the COGS-1 family study. Schizophr Res. 2016 07; 174(1-3):1-9.
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