 Glycine Hydroxymethyltransferase
"Glycine Hydroxymethyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A pyridoxal phosphate enzyme that catalyzes the reaction of glycine and 5,10-methylene-tetrahydrofolate to form serine. It also catalyzes the reaction of glycine with acetaldehyde to form L-threonine. EC 2.1.2.1.
| Descriptor ID |
D012696
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| MeSH Number(s) |
D08.811.913.555.400.500
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| Concept/Terms |
Glycine Hydroxymethyltransferase- Glycine Hydroxymethyltransferase
- Hydroxymethyltransferase, Glycine
- Allothreonine Aldolase
- Aldolase, Allothreonine
- Serine Transhydroxymethylase
- Transhydroxymethylase, Serine
- Serine Hydroxymethylase
- Hydroxymethylase, Serine
- Serine Hydroxymethyltransferase
- Hydroxymethyltransferase, Serine
- Threonine Aldolase
- Aldolase, Threonine
- Serine Aldolase
- Aldolase, Serine
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Below are MeSH descriptors whose meaning is more general than "Glycine Hydroxymethyltransferase".
Below are MeSH descriptors whose meaning is more specific than "Glycine Hydroxymethyltransferase".
This graph shows the total number of publications written about "Glycine Hydroxymethyltransferase" by people in this website by year, and whether "Glycine Hydroxymethyltransferase" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 | | 1999 | 1 | 0 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 1 | 0 | 1 | | 2008 | 1 | 1 | 2 | | 2011 | 2 | 0 | 2 | | 2013 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glycine Hydroxymethyltransferase" by people in Profiles.
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Maclean KN, Jiang H, Phinney WN, Mclagan BM, Roede JR, Stabler SP. Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis. Mol Genet Metab. 2021 02; 132(2):128-138.
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Abarinov EV, Beaudin AE, Field MS, Perry CA, Allen RH, Stabler SP, Stover PJ. Disruption of shmt1 impairs hippocampal neurogenesis and mnemonic function in mice. J Nutr. 2013 Jul; 143(7):1028-35.
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Beaudin AE, Abarinov EV, Malysheva O, Perry CA, Caudill M, Stover PJ. Dietary folate, but not choline, modifies neural tube defect risk in Shmt1 knockout mice. Am J Clin Nutr. 2012 Jan; 95(1):109-14.
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MacFarlane AJ, Anderson DD, Flodby P, Perry CA, Allen RH, Stabler SP, Stover PJ. Nuclear localization of de novo thymidylate biosynthesis pathway is required to prevent uracil accumulation in DNA. J Biol Chem. 2011 Dec 23; 286(51):44015-44022.
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Beaudin AE, Abarinov EV, Noden DM, Perry CA, Chu S, Stabler SP, Allen RH, Stover PJ. Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. Am J Clin Nutr. 2011 Apr; 93(4):789-98.
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MacFarlane AJ, Perry CA, Girnary HH, Gao D, Allen RH, Stabler SP, Shane B, Stover PJ. Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism. J Biol Chem. 2009 Jan 16; 284(3):1533-9.
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MacFarlane AJ, Liu X, Perry CA, Flodby P, Allen RH, Stabler SP, Stover PJ. Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice. J Biol Chem. 2008 Sep 19; 283(38):25846-53.
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Skibola CF, Smith MT, Hubbard A, Shane B, Roberts AC, Law GR, Rollinson S, Roman E, Cartwright RA, Morgan GJ. Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia. Blood. 2002 May 15; 99(10):3786-91.
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Thompson HR, Jones GM, Narkewicz MR. Ontogeny of hepatic enzymes involved in serine- and folate-dependent one-carbon metabolism in rabbits. Am J Physiol Gastrointest Liver Physiol. 2001 May; 280(5):G873-8.
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Narkewicz MR, Moores RR, Battaglia FC, Frerman FF. Ontogeny of serine hydroxymethyltransferase isoenzymes in fetal sheep liver, kidney, and placenta. Mol Genet Metab. 1999 Dec; 68(4):473-80.
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