 Epithelial Sodium Channels
"Epithelial Sodium Channels" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Sodium channels found on salt-reabsorbing EPITHELIAL CELLS that line the distal NEPHRON; the distal COLON; SALIVARY DUCTS; SWEAT GLANDS; and the LUNG. They are AMILORIDE-sensitive and play a critical role in the control of sodium balance, BLOOD VOLUME, and BLOOD PRESSURE.
| Descriptor ID |
D053503
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| MeSH Number(s) |
D12.776.157.530.400.875.200 D12.776.543.550.450.875.200 D12.776.543.585.400.875.200
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| Concept/Terms |
Epithelial Sodium Channels- Epithelial Sodium Channels
- Sodium Channels, Epithelial
- Epithelial Amiloride-Sensitive Sodium Channel
- Epithelial Amiloride Sensitive Sodium Channel
- Epithelial Sodium Ion Channels
- ENaC (Epithelial Na+ Channel)
- Epithelial Sodium Channel
- Sodium Channel, Epithelial
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Below are MeSH descriptors whose meaning is more general than "Epithelial Sodium Channels".
Below are MeSH descriptors whose meaning is more specific than "Epithelial Sodium Channels".
This graph shows the total number of publications written about "Epithelial Sodium Channels" by people in this website by year, and whether "Epithelial Sodium Channels" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2006 | 1 | 1 | 2 | | 2007 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2012 | 2 | 0 | 2 | | 2014 | 2 | 0 | 2 | | 2015 | 1 | 0 | 1 | | 2016 | 0 | 2 | 2 | | 2020 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Epithelial Sodium Channels" by people in Profiles.
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Yadav S, Shaughnessy CA, Zeitlin PL, Bratcher PE. Downregulation of epithelial sodium channel (ENaC) activity in human airway epithelia after low temperature incubation. BMJ Open Respir Res. 2021 02; 8(1).
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Vandenbeuch A, Kinnamon SC. Is the Amiloride-Sensitive Na+ Channel in Taste Cells Really ENaC? Chem Senses. 2020 05 21; 45(4):233-234.
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Livraghi-Butrico A, Grubb BR, Wilkinson KJ, Volmer AS, Burns KA, Evans CM, O'Neal WK, Boucher RC. Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease. Mucosal Immunol. 2017 03; 10(2):395-407.
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Li D, Zou L, Feng Y, Xu G, Gong Y, Zhao G, Ouyang W, Thurman JM, Chao W. Complement Factor B Production in Renal Tubular Cells and Its Role in Sodium Transporter Expression During Polymicrobial Sepsis. Crit Care Med. 2016 May; 44(5):e289-99.
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Nichols DP, Jiang D, Happoldt C, Berman R, Chu HW. Therapeutic Effects of a1-Antitrypsin on Psedumonas aeruginosa Infection in ENaC Transgenic Mice. PLoS One. 2015; 10(10):e0141232.
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Krappitz M, Korbmacher C, Haerteis S. Demonstration of proteolytic activation of the epithelial sodium channel (ENaC) by combining current measurements with detection of cleavage fragments. J Vis Exp. 2014 Jul 05; (89).
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Gupta MD, Girish MP, Sikdar S, Ahuja R, Shah D, Kumar R, Rain M, Nejatizadeh A, Tyagi S, Pasha Q. ?-T594M epithelial sodium channel gene polymorphism and essential hypertension in individuals of Indo-Aryan ancestry in Northern India. Indian Heart J. 2014 Jul-Aug; 66(4):397-400.
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Haerteis S, Krappitz A, Krappitz M, Murphy JE, Bertog M, Krueger B, Nacken R, Chung H, Hollenberg MD, Knecht W, Bunnett NW, Korbmacher C. Proteolytic activation of the human epithelial sodium channel by trypsin IV and trypsin I involves distinct cleavage sites. J Biol Chem. 2014 Jul 04; 289(27):19067-78.
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Peters DM, Vad?sz I, Wujak L, Wygrecka M, Olschewski A, Becker C, Herold S, Papp R, Mayer K, Rummel S, Brandes RP, G?nther A, Waldegger S, Eickelberg O, Seeger W, Morty RE. TGF-? directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):E374-83.
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Haerteis S, Krappitz M, Diakov A, Krappitz A, Rauh R, Korbmacher C. Plasmin and chymotrypsin have distinct preferences for channel activating cleavage sites in the ? subunit of the human epithelial sodium channel. J Gen Physiol. 2012 Oct; 140(4):375-89.
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