 G-Protein-Coupled Receptor Kinase 2
"G-Protein-Coupled Receptor Kinase 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS. It may play an essential role in regulating myocardial contractile response.
| Descriptor ID |
D054769
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| MeSH Number(s) |
D08.811.913.696.620.682.700.364.049.200 D12.644.360.293.249.200 D12.776.476.293.249.200
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "G-Protein-Coupled Receptor Kinase 2".
Below are MeSH descriptors whose meaning is more specific than "G-Protein-Coupled Receptor Kinase 2".
This graph shows the total number of publications written about "G-Protein-Coupled Receptor Kinase 2" by people in this website by year, and whether "G-Protein-Coupled Receptor Kinase 2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 | | 2014 | 1 | 1 | 2 | | 2016 | 2 | 0 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "G-Protein-Coupled Receptor Kinase 2" by people in Profiles.
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Carlson EL, Karuppagounder V, Pinamont WJ, Yoshioka NK, Ahmad A, Schott EM, Le Bleu HK, Zuscik MJ, Elbarbary RA, Kamal F. Paroxetine-mediated GRK2 inhibition is a disease-modifying treatment for osteoarthritis. Sci Transl Med. 2021 02 10; 13(580).
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Denfeld QE, Lee CS, Woodward WR, Hiatt SO, Mudd JO, Habecker BA. Sympathetic Markers are Different Between Clinical Responders and Nonresponders After Left Ventricular Assist Device Implantation. J Cardiovasc Nurs. 2019 Jul/Aug; 34(4):E1-E10.
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Dinkel BA, Kremer KN, Rollins MR, Medlyn MJ, Hedin KE. GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that drives PI3K?/PREX1 signaling and T cell cytokine secretion. J Biol Chem. 2018 09 07; 293(36):14022-14039.
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Travers JG, Kamal FA, Valiente-Alandi I, Nieman ML, Sargent MA, Lorenz JN, Molkentin JD, Blaxall BC. Pharmacological and Activated Fibroblast?Targeting of G??-GRK2 After?Myocardial Ischemia Attenuates Heart Failure Progression. J Am Coll Cardiol. 2017 Aug 22; 70(8):958-971.
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Medina E, Sucharov CC, Nelson P, Miyamoto SD, Stauffer BL. Molecular Changes in Children with Heart Failure Undergoing Left Ventricular Assist Device Therapy. J Pediatr. 2017 03; 182:184-189.e1.
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Hullmann J, Traynham CJ, Coleman RC, Koch WJ. The expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development. Pharmacol Res. 2016 08; 110:52-64.
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Travers JG, Schafer AE, Blaxall BC. GRK2 in Lymphocytes: Expanding the Arsenal of Heart Failure Prognostics. Circ Res. 2016 Apr 01; 118(7):1049-51.
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Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. Simultaneous adrenal and cardiac g-protein-coupled receptor-g?? inhibition halts heart failure progression. J Am Coll Cardiol. 2014 Jun 17; 63(23):2549-2557.
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Clift IC, Bamidele AO, Rodriguez-Ramirez C, Kremer KN, Hedin KE. ?-Arrestin1 and distinct CXCR4 structures are required for stromal derived factor-1 to downregulate CXCR4 cell-surface levels in neuroblastoma. Mol Pharmacol. 2014 Apr; 85(4):542-52.
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Zhu W, Tilley DG, Myers VD, Coleman RC, Feldman AM. Arginine vasopressin enhances cell survival via a G protein-coupled receptor kinase 2/?-arrestin1/extracellular-regulated kinase 1/2-dependent pathway in H9c2 cells. Mol Pharmacol. 2013 Aug; 84(2):227-35.
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