Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Kimberley Bruce

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lietzke EE, Saeb D, Aldrich EC, Bruce KD, Sprenger KG. Synergistic reduction in interfacial flexibility of TREM2R47H and ApoE4 may underlie AD pathology. Alzheimers Dement. 2025 Apr; 21(4):e70120. PMID: 40219843.
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    2. Sturno AM, Hassell JE, Lanaspa MA, Bruce KD. Do microglia metabolize fructose in Alzheimer's disease? J Neuroinflammation. 2025 Mar 15; 22(1):85. PMID: 40089786.
      View in: PubMed
    3. Sun Z, Torphy RJ, Miller EN, Darehshouri A, Vigil I, Terai T, Eck E, Sun Y, Guo Y, Yee EJ, Hu J, Kedl RM, Lasda EL, Hesselberth JR, MacLean P, Bruce KD, Randolph GJ, Schulick RD, Zhu Y. GPR182 is a lipoprotein receptor for dietary fat absorption. bioRxiv. 2025 Feb 07. PMID: 39975353.
      View in: PubMed
    4. Niemeyer CS, Merle L, Bubak AN, Baxter BD, Gentile Polese A, Colon-Reyes K, Vang S, Hassell JE, Bruce KD, Nagel MA, Restrepo D. Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity. J Virol. 2024 Nov 19; 98(11):e0096824. PMID: 39475273.
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    5. Bruce KD, Eckel RH. Are CELSR2 Intronic Variants Genetic Determinants of Energy Balance? J Clin Endocrinol Metab. 2024 Sep 27. PMID: 39328047.
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    6. Niemeyer CS, Merle L, Bubak AN, Dnate' Baxter B, Polese AG, Colon-Reyes K, Vang S, Hassell JE, Bruce KD, Nagel MA, Restrepo D. Olfactory and Trigeminal Routes of HSV-1 CNS Infection with Regional Microglial Heterogeneity. bioRxiv. 2024 Sep 23. PMID: 39386674.
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    7. Niemeyer CS, Frietze S, Coughlan C, Lewis SWR, Bustos Lopez S, Saviola AJ, Hansen KC, Medina EM, Hassell JE, Kogut S, Traina-Dorge V, Nagel MA, Bruce KD, Restrepo D, Mahalingam R, Bubak AN. Suppression of the host antiviral response by non-infectious varicella zoster virus extracellular vesicles. J Virol. 2024 Aug 20; 98(8):e0084824. PMID: 39051773.
      View in: PubMed
    8. Xie W, Bruce K, Belz GT, Farrell HE, Stevenson PG. Indirect CD4+ T cell protection against mouse gamma-herpesvirus infection via interferon gamma. J Virol. 2024 May 14; 98(5):e0049324. PMID: 38578092.
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    9. Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD. Altered metabolism and DAM-signatures in female brains and microglia with aging. Brain Res. 2024 Apr 15; 1829:148772. PMID: 38244754.
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    10. Cleland NRW, Potter GJ, Buck C, Quang D, Oldham D, Neal M, Saviola A, Niemeyer CS, Dobrinskikh E, Bruce KD. Altered Metabolism and DAM-signatures in Female Brains and Microglia with Aging. bioRxiv. 2023 Nov 30. PMID: 38076915.
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    11. Bruce KD, Eckel RH. Can DNA Methylation Predict the Lipid Response to Dietary Intervention? There's a Fat Chance. J Clin Endocrinol Metab. 2023 11 17; 108(12):e1747-e1748. PMID: 37191137.
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    12. Tobeh NS, Bruce KD. Emerging Alzheimer's disease therapeutics: promising insights from lipid metabolism and microglia-focused interventions. Front Aging Neurosci. 2023; 15:1259012. PMID: 38020773.
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    13. Lightbourne M, Startzell M, Bruce KD, Brite B, Muniyappa R, Skarulis M, Shamburek R, Gharib AM, Ouwerkerk R, Walter M, Eckel RH, Brown RJ. Volanesorsen, an antisense oligonucleotide to apolipoprotein C-III, increases lipoprotein lipase activity and lowers triglycerides in partial lipodystrophy. J Clin Lipidol. 2022 Nov-Dec; 16(6):850-862. PMID: 36195542.
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    14. Cleland NRW, Bruce KD. Fatty acid sensing in the brain: The role of glial-neuronal metabolic crosstalk and horizontal lipid flux. Biochimie. 2024 Aug; 223:166-178. PMID: 35998849.
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    15. Oldham D, Wang H, Mullen J, Lietzke E, Sprenger K, Reigan P, Eckel RH, Bruce KD. Using Synthetic ApoC-II Peptides and nAngptl4 Fragments to Measure Lipoprotein Lipase Activity in Radiometric and Fluorescent Assays. Front Cardiovasc Med. 2022; 9:926631. PMID: 35911520.
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    16. Eckel RH, Bruce KD. Statins, gut microbiome, LDL-C, glucose intolerance: Personalized medicine timely? Med. 2022 06 10; 3(6):355-357. PMID: 35690054.
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    17. Xie W, Lee B, Bruce K, Lawler C, Farrell HE, Stevenson PG. CD4+ T Cells Control Murine Cytomegalovirus Infection Indirectly. J Virol. 2022 04 13; 96(7):e0007722. PMID: 35293772.
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    18. Ma J, Bruce K, Davis-Poynter N, Stevenson PG, Farrell HE. The Mouse Cytomegalovirus G Protein-Coupled Receptor Homolog, M33, Coordinates Key Features of In Vivo Infection via Distinct Components of Its Signaling Repertoire. J Virol. 2022 02 23; 96(4):e0186721. PMID: 34878888.
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    19. Cleland NRW, Al-Juboori SI, Dobrinskikh E, Bruce KD. Altered substrate metabolism in neurodegenerative disease: new insights from metabolic imaging. J Neuroinflammation. 2021 Oct 28; 18(1):248. PMID: 34711251.
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    20. Bruce KD, Yassine HN, Fonteh AN. Editorial: Lipid Metabolism and Transport in CNS Health and Disease. Front Physiol. 2021; 12:768417. PMID: 34721089.
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    21. Guttenplan KA, Weigel MK, Prakash P, Wijewardhane PR, Hasel P, Rufen-Blanchette U, M?nch AE, Blum JA, Fine J, Neal MC, Bruce KD, Gitler AD, Chopra G, Liddelow SA, Barres BA. Neurotoxic reactive astrocytes induce cell death via saturated lipids. Nature. 2021 11; 599(7883):102-107. PMID: 34616039.
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    22. Xie W, Bruce K, Farrell HE, Stevenson PG. Olfactory Entry Promotes Herpesvirus Recombination. J Virol. 2021 11 09; 95(23):e0155521. PMID: 34523965.
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    23. Farrell HE, Bruce K, Stevenson PG. A Live Olfactory Mouse Cytomegalovirus Vaccine, Attenuated for Systemic Spread, Protects against Superinfection. J Virol. 2021 10 13; 95(21):e0126421. PMID: 34431701.
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    24. Ma J, Bruce K, Stevenson PG, Farrell HE. Murine Cytomegalovirus MCK-2 Facilitates In Vivo Infection Transfer from Dendritic Cells to Salivary Gland Acinar Cells. J Virol. 2021 08 10; 95(17):e0069321. PMID: 34132572.
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    25. Loving BA, Tang M, Neal MC, Gorkhali S, Murphy R, Eckel RH, Bruce KD. Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation. Cells. 2021 01 20; 10(2). PMID: 33498265.
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    26. Joshi M, Kim J, D'Alessandro A, Monk E, Bruce K, Elajaili H, Nozik-Grayck E, Goodspeed A, Costello JC, Schlaepfer IR. CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer. Cancers (Basel). 2020 Nov 18; 12(11). PMID: 33218188.
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    27. Bruce KD, Dobrinskikh E, Wang H, Rudenko I, Gao H, Libby AE, Gorkhali S, Yu T, Zsombok A, Eckel RH. Neuronal Lipoprotein Lipase Deficiency Alters Neuronal Function and Hepatic Metabolism. Metabolites. 2020 Sep 28; 10(10). PMID: 32998280.
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    28. Coughlan C, Bruce KD, Burgy O, Boyd TD, Michel CR, Garcia-Perez JE, Adame V, Anton P, Bettcher BM, Chial HJ, K?nigshoff M, Hsieh EWY, Graner M, Potter H. Exosome Isolation by Ultracentrifugation and Precipitation and Techniques for Downstream Analyses. Curr Protoc Cell Biol. 2020 09; 88(1):e110. PMID: 32633898.
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    29. Loving BA, Bruce KD. Lipid and Lipoprotein Metabolism in Microglia. Front Physiol. 2020; 11:393. PMID: 32411016.
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    30. Amison RT, Faure ME, O'Shaughnessy BG, Bruce KD, Hu Y, Coates A, Page CP. The small quinolone derived compound HT61 enhances the effect of tobramycin against Pseudomonas aeruginosa in vitro and in vivo. Pulm Pharmacol Ther. 2020 04; 61:101884. PMID: 31887372.
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    31. Cleal JK, Bruce KD, Shearer JL, Thomas H, Plume J, Gregory L, Shepard JN, Spiers-Fitzgerald KL, Mani R, Lewis RM, Lillycrop KA, Hanson MA, Byrne CD, Cagampang FR. Maternal Obesity during Pregnancy Alters Daily Activity and Feeding Cycles, and Hypothalamic Clock Gene Expression in Adult Male Mouse Offspring. Int J Mol Sci. 2019 Oct 30; 20(21). PMID: 31671625.
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    32. Farrell HE, Bruce K, Lawler C, Stevenson PG. Murine Cytomegalovirus Spread Depends on the Infected Myeloid Cell Type. J Virol. 2019 08 01; 93(15). PMID: 31092580.
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    33. Yunis J, Farrell HE, Bruce K, Lawler C, Wyer O, Davis-Poynter N, Brizic I, Jonjic S, Adler B, Stevenson PG. Murine Cytomegalovirus Glycoprotein O Promotes Epithelial Cell Infection In Vivo. J Virol. 2019 02 01; 93(3). PMID: 30404805.
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    34. Jonscher KR, Bruce KD. Current Models of Fatty Liver Disease; New Insights, Therapeutic Targets and Interventions. Adv Exp Med Biol. 2019; 1134:33-58. PMID: 30919331.
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    35. Bruce KD, Gorkhali S, Given K, Coates AM, Boyle KE, Macklin WB, Eckel RH. Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination. Front Mol Neurosci. 2018; 11:57. PMID: 29599706.
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    36. Bruce KD, Jonscher KR. Assessment of Fatty Liver in Models of Disease Programming. Methods Mol Biol. 2018; 1735:251-266. PMID: 29380318.
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    37. Laperrousaz E, Moull? VS, Denis RG, Kassis N, Berland C, Colsch B, Fioramonti X, Philippe E, Lacombe A, Vanacker C, Butin N, Bruce KD, Wang H, Wang Y, Gao Y, Garcia-Caceres C, Pr?vot V, Tsch?p MH, Eckel RH, Le Stunff H, Luquet S, Magnan C, Cruciani-Guglielmacci C. Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice. Diabetologia. 2017 07; 60(7):1314-1324. PMID: 28456865.
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    38. Bruce KD, Zsombok A, Eckel RH. Lipid Processing in the Brain: A Key Regulator of Systemic Metabolism. Front Endocrinol (Lausanne). 2017; 8:60. PMID: 28421037.
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    39. Taha DA, Zgair A, Lee JB, de Moor CH, Barrett DA, Bruce KD, Sungelo M, Eckel RH, Gershkovich P. Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity. Eur J Pharm Sci. 2017 Mar 30; 100:163-175. PMID: 28104473.
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    40. Bruce KD, Szczepankiewicz D, Sihota KK, Ravindraanandan M, Thomas H, Lillycrop KA, Burdge GC, Hanson MA, Byrne CD, Cagampang FR. Altered cellular redox status, sirtuin abundance and clock gene expression in a mouse model of developmentally primed NASH. Biochim Biophys Acta. 2016 Jul; 1861(7):584-93. PMID: 27040510.
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    41. Wang H, Taussig MD, DiPatrizio NV, Bruce K, Piomelli D, Eckel RH. Obesity development in neuron-specific lipoprotein lipase deficient mice is not responsive to increased dietary fat content or change in fat composition. Metabolism. 2016 07; 65(7):987-97. PMID: 27282869.
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    42. Farrell HE, Davis-Poynter N, Bruce K, Lawler C, Dolken L, Mach M, Stevenson PG. Lymph Node Macrophages Restrict Murine Cytomegalovirus Dissemination. J Virol. 2015 Jul; 89(14):7147-58. PMID: 25926638.
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    43. Cheong Y, Sadek KH, Bruce KD, Macklon N, Cagampang FR. Diet-induced maternal obesity alters ovarian morphology and gene expression in the adult mouse offspring. Fertil Steril. 2014 Sep; 102(3):899-907. PMID: 25063726.
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    44. Cleal JK, Shepherd JN, Shearer JL, Bruce KD, Cagampang FR. Sensitivity of housekeeping genes in the suprachiasmatic nucleus of the mouse brain to diet and the daily light-dark cycle. Brain Res. 2014 Aug 05; 1575:72-7. PMID: 24881883.
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    45. Torrens C, Ethirajan P, Bruce KD, Cagampang FR, Siow RC, Hanson MA, Byrne CD, Mann GE, Clough GF. Interaction between maternal and offspring diet to impair vascular function and oxidative balance in high fat fed male mice. PLoS One. 2012; 7(12):e50671. PMID: 23227196.
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    46. Sadek KH, Cagampang FR, Bruce KD, Macklon N, Cheong Y. Variation in stability of housekeeping genes in healthy and adhesion-related mesothelium. Fertil Steril. 2012 Oct; 98(4):1023-7. PMID: 22795637.
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    47. Cagampang FR, Bruce KD. The role of the circadian clock system in nutrition and metabolism. Br J Nutr. 2012 Aug; 108(3):381-92. PMID: 22676899.
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    48. Bruce KD, Sihota KK, Byrne CD, Cagampang FR. The housekeeping gene YWHAZ remains stable in a model of developmentally primed non-alcoholic fatty liver disease. Liver Int. 2012 Sep; 32(8):1315-21. PMID: 22583519.
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    49. Sadek KH, Cagampang FR, Bruce KD, Shreeve N, Macklon N, Cheong Y. Variation in stability of housekeeping genes in endometrium of healthy and polycystic ovarian syndrome women. Hum Reprod. 2012 Jan; 27(1):251-6. PMID: 22052386.
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    50. Bruce KD, Cagampang FR. Epigenetic priming of the metabolic syndrome. Toxicol Mech Methods. 2011 May; 21(4):353-61. PMID: 21495873.
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    51. Sadek K, Macklon N, Bruce K, Cagampang F, Cheong Y. Hypothesis: Role for the circadian Clock system and sleep in the pathogenesis of adhesions and chronic pelvic pain? Med Hypotheses. 2011 Mar; 76(3):453-6. PMID: 21146320.
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    52. Bruce KD, Hanson MA. The developmental origins, mechanisms, and implications of metabolic syndrome. J Nutr. 2010 Mar; 140(3):648-52. PMID: 20107145.
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    53. Bruce KD, Cagampang FR, Argenton M, Zhang J, Ethirajan PL, Burdge GC, Bateman AC, Clough GF, Poston L, Hanson MA, McConnell JM, Byrne CD. Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology. 2009 Dec; 50(6):1796-808. PMID: 19816994.
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    54. Bruce KD, Byrne CD. The metabolic syndrome: common origins of a multifactorial disorder. Postgrad Med J. 2009 Nov; 85(1009):614-21. PMID: 19892897.
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    55. Zhang J, Zhang F, Didelot X, Bruce KD, Cagampang FR, Vatish M, Hanson M, Lehnert H, Ceriello A, Byrne CD. Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring. BMC Genomics. 2009 Oct 16; 10:478. PMID: 19835573.
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    56. Byrne CD, Olufadi R, Bruce KD, Cagampang FR, Ahmed MH. Metabolic disturbances in non-alcoholic fatty liver disease. Clin Sci (Lond). 2009 Apr; 116(7):539-64. PMID: 19243311.
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