 Two-Hybrid System Techniques
"Two-Hybrid System Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.
| Descriptor ID |
D020798
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| MeSH Number(s) |
E05.393.220.870 E05.601.690.650 E05.601.870
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| Concept/Terms |
Two-Hybrid System Techniques- Two-Hybrid System Techniques
- Technique, Two-Hybrid System
- Techniques, Two-Hybrid System
- Two Hybrid System Techniques
- Two-Hybrid System Technique
- Two-Hybrid Method
- Method, Two-Hybrid
- Methods, Two-Hybrid
- Two Hybrid Method
- Two-Hybrid Methods
- Two-Hybrid System Technics
- Technic, Two-Hybrid System
- Technics, Two-Hybrid System
- Two Hybrid System Technics
- Two-Hybrid System Technic
- Two-Hybrid Assay
- Assay, Two-Hybrid
- Assays, Two-Hybrid
- Two Hybrid Assay
- Two-Hybrid Assays
One-Hybrid System Techniques- One-Hybrid System Techniques
- One Hybrid System Techniques
- One-Hybrid System Technique
- Technique, One-Hybrid System
- Techniques, One-Hybrid System
- One-Hybrid System Technics
- One Hybrid System Technics
- One-Hybrid System Technic
- Technic, One-Hybrid System
- Technics, One-Hybrid System
Yeast Two-Hybrid System Techniques- Yeast Two-Hybrid System Techniques
- Yeast Two Hybrid System Techniques
- Yeast Two-Hybrid System
- System, Yeast Two-Hybrid
- Systems, Yeast Two-Hybrid
- Two-Hybrid System, Yeast
- Two-Hybrid Systems, Yeast
- Yeast Two Hybrid System
- Yeast Two-Hybrid Systems
- Yeast Two-Hybrid Assay
- Assay, Yeast Two-Hybrid
- Assays, Yeast Two-Hybrid
- Two-Hybrid Assay, Yeast
- Two-Hybrid Assays, Yeast
- Yeast Two Hybrid Assay
- Yeast Two-Hybrid Assays
Three-Hybrid System Techniques- Three-Hybrid System Techniques
- Technique, Three-Hybrid System
- Techniques, Three-Hybrid System
- Three Hybrid System Techniques
- Three-Hybrid System Technique
- Tri-Hybrid System Techniques
- Technique, Tri-Hybrid System
- Techniques, Tri-Hybrid System
- Tri Hybrid System Techniques
- Tri-Hybrid System Technique
- Three-Hybrid System Technics
- Technic, Three-Hybrid System
- Technics, Three-Hybrid System
- Three Hybrid System Technics
- Three-Hybrid System Technic
Yeast Three-Hybrid System Techniques- Yeast Three-Hybrid System Techniques
- Yeast Three Hybrid System Techniques
- Yeast Three-Hybrid System
- System, Yeast Three-Hybrid
- Systems, Yeast Three-Hybrid
- Three-Hybrid System, Yeast
- Three-Hybrid Systems, Yeast
- Yeast Three Hybrid System
- Yeast Three-Hybrid Systems
- Yeast Three-Hybrid Assay
- Assay, Yeast Three-Hybrid
- Assays, Yeast Three-Hybrid
- Three-Hybrid Assay, Yeast
- Three-Hybrid Assays, Yeast
- Yeast Three Hybrid Assay
- Yeast Three-Hybrid Assays
n-Hybrid System Techniques- n-Hybrid System Techniques
- System Technique, n-Hybrid
- System Techniques, n-Hybrid
- Technique, n-Hybrid System
- Techniques, n-Hybrid System
- n Hybrid System Techniques
- n-Hybrid System Technique
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Below are MeSH descriptors whose meaning is more general than "Two-Hybrid System Techniques".
Below are MeSH descriptors whose meaning is more specific than "Two-Hybrid System Techniques".
This graph shows the total number of publications written about "Two-Hybrid System Techniques" by people in this website by year, and whether "Two-Hybrid System Techniques" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2000 | 0 | 4 | 4 | | 2001 | 0 | 3 | 3 | | 2002 | 0 | 6 | 6 | | 2003 | 0 | 3 | 3 | | 2004 | 0 | 2 | 2 | | 2005 | 1 | 5 | 6 | | 2006 | 0 | 2 | 2 | | 2007 | 0 | 5 | 5 | | 2008 | 0 | 2 | 2 | | 2009 | 1 | 1 | 2 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2012 | 1 | 2 | 3 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2015 | 0 | 2 | 2 | | 2016 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 2 | 2 |
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Below are the most recent publications written about "Two-Hybrid System Techniques" by people in Profiles.
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Raeeszadeh-Sarmazdeh M, Greene KA, Sankaran B, Downey GP, Radisky DC, Radisky ES. Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition. J Biol Chem. 2019 06 14; 294(24):9476-9488.
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Battaglino RA, Jha P, Sultana F, Liu W, Morse LR. FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts. J Cell Biochem. 2019 08; 120(8):13321-13329.
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Dahlstrom KM, Collins AJ, Doing G, Taroni JN, Gauvin TJ, Greene CS, Hogan DA, O'Toole GA. A Multimodal Strategy Used by a Large c-di-GMP Network. J Bacteriol. 2018 04 15; 200(8).
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Klesmith JR, Bacik JP, Wrenbeck EE, Michalczyk R, Whitehead TA. Trade-offs between enzyme fitness and solubility illuminated by deep mutational scanning. Proc Natl Acad Sci U S A. 2017 02 28; 114(9):2265-2270.
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Kowalsky CA, Whitehead TA. Determination of binding affinity upon mutation for type I dockerin-cohesin complexes from Clostridium thermocellum and Clostridium cellulolyticum using deep sequencing. Proteins. 2016 12; 84(12):1914-1928.
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Hirasaka K, Mills EM, Haruna M, Bando A, Ikeda C, Abe T, Kohno S, Nowinski SM, Lago CU, Akagi K, Tochio H, Ohno A, Teshima-Kondo S, Okumura Y, Nikawa T. UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion. Biochem Biophys Res Commun. 2016 Mar 25; 472(1):108-13.
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Spiltoir JI, Strickland D, Glotzer M, Tucker CL. Optical Control of Peroxisomal Trafficking. ACS Synth Biol. 2016 07 15; 5(7):554-60.
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Thomas LR, Wang Q, Grieb BC, Phan J, Foshage AM, Sun Q, Olejniczak ET, Clark T, Dey S, Lorey S, Alicie B, Howard GC, Cawthon B, Ess KC, Eischen CM, Zhao Z, Fesik SW, Tansey WP. Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC. Mol Cell. 2015 May 07; 58(3):440-52.
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Taslimi A, Vrana JD, Chen D, Borinskaya S, Mayer BJ, Kennedy MJ, Tucker CL. An optimized optogenetic clustering tool for probing protein interaction and function. Nat Commun. 2014 Sep 18; 5:4925.
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Pierce JB, Chafe SC, Eswara MB, van der Merwe G, Mangroo D. Strategies for investigating nuclear-cytoplasmic tRNA dynamics in yeast and mammalian cells. Methods Cell Biol. 2014; 122:415-36.
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