 Open Reading Frames
"Open Reading Frames" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
| Descriptor ID |
D016366
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| MeSH Number(s) |
G05.360.335.760.640 G05.360.340.024.340.137.650
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| Concept/Terms |
Open Reading Frames- Open Reading Frames
- Frame, Open Reading
- Frames, Open Reading
- Open Reading Frame
- Reading Frame, Open
- Reading Frames, Open
- ORFs
- Protein Coding Region
- Coding Region, Protein
- Coding Regions, Protein
- Protein Coding Regions
- Region, Protein Coding
- Regions, Protein Coding
Unassigned Reading Frames- Unassigned Reading Frames
- Frame, Unassigned Reading
- Frames, Unassigned Reading
- Reading Frame, Unassigned
- Reading Frames, Unassigned
- Unassigned Reading Frame
- Unidentified Reading Frame
- Frame, Unidentified Reading
- Frames, Unidentified Reading
- Reading Frame, Unidentified
- Reading Frames, Unidentified
- Unidentified Reading Frames
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Below are MeSH descriptors whose meaning is more general than "Open Reading Frames".
Below are MeSH descriptors whose meaning is more specific than "Open Reading Frames".
This graph shows the total number of publications written about "Open Reading Frames" by people in this website by year, and whether "Open Reading Frames" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 | | 2000 | 1 | 4 | 5 | | 2001 | 0 | 2 | 2 | | 2002 | 0 | 1 | 1 | | 2003 | 0 | 2 | 2 | | 2004 | 1 | 3 | 4 | | 2005 | 0 | 4 | 4 | | 2006 | 1 | 3 | 4 | | 2007 | 2 | 3 | 5 | | 2008 | 1 | 3 | 4 | | 2009 | 0 | 4 | 4 | | 2010 | 1 | 2 | 3 | | 2011 | 2 | 4 | 6 | | 2012 | 3 | 3 | 6 | | 2013 | 2 | 7 | 9 | | 2014 | 1 | 2 | 3 | | 2015 | 0 | 4 | 4 | | 2016 | 1 | 2 | 3 | | 2017 | 0 | 2 | 2 | | 2018 | 2 | 3 | 5 | | 2019 | 2 | 4 | 6 | | 2020 | 0 | 1 | 1 | | 2021 | 1 | 3 | 4 | | 2023 | 0 | 1 | 1 | | 2024 | 1 | 1 | 2 | | 2025 | 2 | 0 | 2 |
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Below are the most recent publications written about "Open Reading Frames" by people in Profiles.
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Walters K, Castro-Gutierrez R, Sarkar S, Baldwin A, Baker AS, Shilleh AH, Anderson AM, Nakayama M, Fugman T, Nakayasu ES, Mukherjee N, Russ HA. Proteogenomic Discovery of Novel Open Reading Frames With HLA Immune Presentation on Human ß-Cells. Diabetes. 2025 Dec 01; 74(12):2322-2336.
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Tonsager AJ, Zukowski A, Radebaugh CA, Weirich A, Stargell LA, Ramachandran S. The histone chaperone Spn1 preserves chromatin protections at promoters and nucleosome positioning in open reading frames. G3 (Bethesda). 2025 Apr 17; 15(4).
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Whited AM, Jungreis I, Allen J, Cleveland CL, Mudge JM, Kellis M, Rinn JL, Hough LE. Biophysical characterization of high-confidence, small human proteins. Biophys Rep (N Y). 2024 Sep 11; 4(3):100167.
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Musaev D, Abdelmessih M, Vejnar CE, Yartseva V, Weiss LA, Strayer EC, Takacs CM, Giraldez AJ. UPF1 regulates mRNA stability by sensing poorly translated coding sequences. Cell Rep. 2024 04 23; 43(4):114074.
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May GE, Akirtava C, Agar-Johnson M, Micic J, Woolford J, McManus J. Unraveling the influences of sequence and position on yeast uORF activity using massively parallel reporter systems and machine learning. Elife. 2023 05 25; 12.
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Sherlock ME, Baquero Galvis L, Vicens Q, Kieft JS, Jagannathan S. Principles, mechanisms, and biological implications of translation termination-reinitiation. RNA. 2023 07; 29(7):865-884.
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Kidwell A, Yadav SPS, Maier B, Zollman A, Ni K, Halim A, Janosevic D, Myslinski J, Syed F, Zeng L, Waffo AB, Banno K, Xuei X, Doud EH, Dagher PC, Hato T. Translation Rescue by Targeting Ppp1r15a through Its Upstream Open Reading Frame in Sepsis-Induced Acute Kidney Injury in a Murine Model. J Am Soc Nephrol. 2023 02 01; 34(2):220-240.
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Hindy G, Dornbos P, Chaffin MD, Liu DJ, Wang M, Selvaraj MS, Zhang D, Park J, Aguilar-Salinas CA, Antonacci-Fulton L, Ardissino D, Arnett DK, Aslibekyan S, Atzmon G, Ballantyne CM, Barajas-Olmos F, Barzilai N, Becker LC, Bielak LF, Bis JC, Blangero J, Boerwinkle E, Bonnycastle LL, Bottinger E, Bowden DW, Bown MJ, Brody JA, Broome JG, Burtt NP, Cade BE, Centeno-Cruz F, Chan E, Chang YC, Chen YI, Cheng CY, Choi WJ, Chowdhury R, Contreras-Cubas C, Córdova EJ, Correa A, Cupples LA, Curran JE, Danesh J, de Vries PS, DeFronzo RA, Doddapaneni H, Duggirala R, Dutcher SK, Ellinor PT, Emery LS, Florez JC, Fornage M, Freedman BI, Fuster V, Garay-Sevilla ME, García-Ortiz H, Germer S, Gibbs RA, Gieger C, Glaser B, Gonzalez C, Gonzalez-Villalpando ME, Graff M, Graham SE, Grarup N, Groop LC, Guo X, Gupta N, Han S, Hanis CL, Hansen T, He J, Heard-Costa NL, Hung YJ, Hwang MY, Irvin MR, Islas-Andrade S, Jarvik GP, Kang HM, Kardia SLR, Kelly T, Kenny EE, Khan AT, Kim BJ, Kim RW, Kim YJ, Koistinen HA, Kooperberg C, Kuusisto J, Kwak SH, Laakso M, Lange LA, Lee J, Lee J, Lee S, Lehman DM, Lemaitre RN, Linneberg A, Liu J, Loos RJF, Lubitz SA, Lyssenko V, Ma RCW, Martin LW, Martínez-Hernández A, Mathias RA, McGarvey ST, McPherson R, Meigs JB, Meitinger T, Melander O, Mendoza-Caamal E, Metcalf GA, Mi X, Mohlke KL, Montasser ME, Moon JY, Moreno-Macías H, Morrison AC, Muzny DM, Nelson SC, Nilsson PM, O'Connell JR, Orho-Melander M, Orozco L, Palmer CNA, Palmer ND, Park CJ, Park KS, Pedersen O, Peralta JM, Peyser PA, Post WS, Preuss M, Psaty BM, Qi Q, Rao DC, Redline S, Reiner AP, Revilla-Monsalve C, Rich SS, Samani N, Schunkert H, Schurmann C, Seo D, Seo JS, Sim X, Sladek R, Small KS, So WY, Stilp AM, Tai ES, Tam CHT, Taylor KD, Teo YY, Thameem F, Tomlinson B, Tsai MY, Tuomi T, Tuomilehto J, Tusié-Luna T, Udler MS, van Dam RM, Vasan RS, Viaud Martinez KA, Wang FF, Wang X, Watkins H, Weeks DE, Wilson JG, Witte DR, Wong TY, Yanek LR, Kathiresan S, Rader DJ, Rotter JI, Boehnke M, McCarthy MI, Willer CJ, Natarajan P, Flannick JA, Khera AV, Peloso GM. Rare coding variants in 35 genes associate with circulating lipid levels-A multi-ancestry analysis of 170,000 exomes. Am J Hum Genet. 2022 01 06; 109(1):81-96.
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Xie W, Bruce K, Farrell HE, Stevenson PG. Olfactory Entry Promotes Herpesvirus Recombination. J Virol. 2021 11 09; 95(23):e0155521.
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Llerena Cari E, Hagen-Lillevik S, Giornazi A, Post M, Komar AA, Appiah L, Bitler B, Polotsky AJ, Santoro N, Kieft J, Lai K, Johnson J. Integrated stress response control of granulosa cell translation and proliferation during normal ovarian follicle development. Mol Hum Reprod. 2021 08 07; 27(8).
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