 Thapsigargin
"Thapsigargin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sesquiterpene lactone found in roots of THAPSIA. It inhibits SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES.
| Descriptor ID |
D019284
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| MeSH Number(s) |
D02.455.426.392.368.284.500.888 D02.455.849.765.793.888
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Thapsigargin".
Below are MeSH descriptors whose meaning is more specific than "Thapsigargin".
This graph shows the total number of publications written about "Thapsigargin" by people in this website by year, and whether "Thapsigargin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 1999 | 0 | 3 | 3 | | 2002 | 0 | 2 | 2 | | 2006 | 0 | 3 | 3 | | 2007 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thapsigargin" by people in Profiles.
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Yun B, Lee H, Ewing H, Gelb MH, Leslie CC. Off-target effect of the cPLA2a inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulum. Biochem Biophys Res Commun. 2016 10 07; 479(1):61-6.
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Keestra-Gounder AM, Byndloss MX, Seyffert N, Young BM, Ch?vez-Arroyo A, Tsai AY, Cevallos SA, Winter MG, Pham OH, Tiffany CR, de Jong MF, Kerrinnes T, Ravindran R, Luciw PA, McSorley SJ, B?umler AJ, Tsolis RM. NOD1 and NOD2 signalling links ER stress with inflammation. Nature. 2016 Apr 21; 532(7599):394-7.
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Perni S, Dynes JL, Yeromin AV, Cahalan MD, Franzini-Armstrong C. Nanoscale patterning of STIM1 and Orai1 during store-operated Ca2+ entry. Proc Natl Acad Sci U S A. 2015 Oct 06; 112(40):E5533-42.
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Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. J Biol Chem. 2014 Jan 17; 289(3):1491-504.
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Roberson EC, Tully JE, Guala AS, Reiss JN, Godburn KE, Pociask DA, Alcorn JF, Riches DW, Dienz O, Janssen-Heininger YM, Anathy V. Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-? release in lung epithelial cells. Am J Respir Cell Mol Biol. 2012 May; 46(5):573-81.
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Choudhury M, Qadri I, Rahman SM, Schroeder-Gloeckler J, Janssen RC, Friedman JE. C/EBP? is AMP kinase sensitive and up-regulates PEPCK in response to ER stress in hepatoma cells. Mol Cell Endocrinol. 2011 Jan 01; 331(1):102-8.
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Rahman SM, Qadri I, Janssen RC, Friedman JE. Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis. J Lipid Res. 2009 Nov; 50(11):2193-202.
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Rokhlin OW, Taghiyev AF, Bayer KU, Bumcrot D, Koteliansk VE, Glover RA, Cohen MB. Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival. Cancer Biol Ther. 2007 May; 6(5):732-42.
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Song Z, Vijayaraghavan S, Sladek CD. ATP increases intracellular calcium in supraoptic neurons by activation of both P2X and P2Y purinergic receptors. Am J Physiol Regul Integr Comp Physiol. 2007 Jan; 292(1):R423-31.
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Song Z, Vijayaraghavan S, Sladek CD. Simultaneous exposure to ATP and phenylephrine induces a sustained elevation in the intracellular calcium concentration in supraoptic neurons. Am J Physiol Regul Integr Comp Physiol. 2006 Jul; 291(1):R37-45.
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