 Prokaryotic Initiation Factor-3
"Prokaryotic Initiation Factor-3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A prokaryotic initiation factor that plays a role in recycling of ribosomal subunits for a new round of translational initiation. It binds to 16S RIBOSOMAL RNA and stimulates the dissociation of vacant 70S ribosomes. It may also be involved in the preferential binding of initiator tRNA to the 30S initiation complex.
| Descriptor ID |
D039665
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| MeSH Number(s) |
D12.776.835.725.934.750
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| Concept/Terms |
Prokaryotic Initiation Factor-3- Prokaryotic Initiation Factor-3
- Initiation Factor-3, Prokaryotic
- Prokaryotic Initiation Factor 3
- Peptide Initiation Factor 3
- Translation Initiation Factor 3
- Prokaryotic Peptide Initiation Factor-3
- Prokaryotic Peptide Initiation Factor 3
- TIF IF3
- Initiation Factor IF-3
- IF-3, Initiation Factor
- Initiation Factor IF 3
- Peptide Initiation Factor IF-3
- Peptide Initiation Factor IF 3
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Below are MeSH descriptors whose meaning is more general than "Prokaryotic Initiation Factor-3".
Below are MeSH descriptors whose meaning is more specific than "Prokaryotic Initiation Factor-3".
This graph shows the total number of publications written about "Prokaryotic Initiation Factor-3" by people in this website by year, and whether "Prokaryotic Initiation Factor-3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Prokaryotic Initiation Factor-3" by people in Profiles.
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Hussain T, Ll?cer JL, Wimberly BT, Kieft JS, Ramakrishnan V. Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation. Cell. 2016 Sep 22; 167(1):133-144.e13.
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Kieft JS, Zhou K, Grech A, Jubin R, Doudna JA. Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation. Nat Struct Biol. 2002 May; 9(5):370-4.
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Shapkina TG, Dolan MA, Babin P, Wollenzien P. Initiation factor 3-induced structural changes in the 30 S ribosomal subunit and in complexes containing tRNA(f)(Met) and mRNA. J Mol Biol. 2000 Jun 09; 299(3):615-28.
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Kieft JS, Zhou K, Jubin R, Murray MG, Lau JY, Doudna JA. The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold. J Mol Biol. 1999 Sep 24; 292(3):513-29.
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Hartz D, Binkley J, Hollingsworth T, Gold L. Domains of initiator tRNA and initiation codon crucial for initiator tRNA selection by Escherichia coli IF3. Genes Dev. 1990 Oct; 4(10):1790-800.
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Hartz D, McPheeters DS, Gold L. Selection of the initiator tRNA by Escherichia coli initiation factors. Genes Dev. 1989 Dec; 3(12A):1899-912.
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