 Brian T Wimberly
| Title | Affiliate |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-BioChem&Molecular Genetics |
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 Research R21AI193830 (WIMBERLY, BRIAN T)Jul 1, 2025 - Jun 30, 2027 NIH
Architecture of a divergent bipartite internal ribosome entry site from Giardiavirus
Role: Principal Investigator |
| R21AI149210 (RISSLAND, OLIVIA SELFRIDGE)Mar 1, 2020 - Feb 28, 2022 NIH
Mechanisms of protein production in the parasite Giardia Iamblia
Role: Co-Principal Investigator |
| F32GM015181 (WIMBERLY, BRIAN T)Feb 14, 1994 NIH
SOLUTION STRUCTURE OF A EUKARYOTIC RIBOSOMAL PROTEIN
Role: Principal Investigator |
Bibliographic
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Gezelle JG, Korn SM, McDonald JT, Gong Z, Erickson A, Huang CH, Yang F, Cronin M, Kuo YW, Wimberly BT, Steckelberg AL. A conserved viral RNA fold enables nuclease resistance across kingdoms of life. Nucleic Acids Res. 2025 Aug 27; 53(16). PMID: 40884403.
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Gezelle JG, Korn SM, McDonald JT, Gong Z, Erickson A, Huang CH, Yang F, Cronin M, Kuo YW, Wimberly BT, Steckelberg AL. The pseudoknot structure of a viral RNA reveals a conserved mechanism for programmed exoribonuclease resistance. bioRxiv. 2024 Dec 18. PMID: 39763890.
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Eiler DR, Wimberly BT, Bilodeau DY, Taliaferro JM, Reigan P, Rissland OS, Kieft JS. The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function. Structure. 2024 04 04; 32(4):400-410.e4. PMID: 38242118.
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Hartwick EW, Wimberly BT. Resolving Late-Stage Intermediates of Eukaryotic Ribosome Assembly. Structure. 2017 02 07; 25(2):216-218. PMID: 28178457.
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Hussain T, Llácer JL, Wimberly BT, Kieft JS, Ramakrishnan V. Large-Scale Movements of IF3 and tRNA during Bacterial Translation Initiation. Cell. 2016 Sep 22; 167(1):133-144.e13. PMID: 27662086.
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Clayton GM, Wang Y, Crawford F, Novikov A, Wimberly BT, Kieft JS, Falta MT, Bowerman NA, Marrack P, Fontenot AP, Dai S, Kappler JW. Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity. Cell. 2014 Jul 03; 158(1):132-42. PMID: 24995984.
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Wimberly BT. The use of ribosomal crystal structures in antibiotic drug design. Curr Opin Investig Drugs. 2009 Aug; 10(8):750-65. PMID: 19649920.
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Brodersen DE, Clemons WM, Carter AP, Wimberly BT, Ramakrishnan V. Phasing the 30S ribosomal subunit structure. Acta Crystallogr D Biol Crystallogr. 2003 Nov; 59(Pt 11):2044-50. PMID: 14573961.
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Brodersen DE, Clemons WM, Carter AP, Wimberly BT, Ramakrishnan V. Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: structure of the proteins and their interactions with 16 S RNA. J Mol Biol. 2002 Feb 22; 316(3):725-68. PMID: 11866529.
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Clemons WM, Brodersen DE, McCutcheon JP, May JL, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V. Crystal structure of the 30 S ribosomal subunit from Thermus thermophilus: purification, crystallization and structure determination. J Mol Biol. 2001 Jul 20; 310(4):827-43. PMID: 11453691.
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Carter AP, Clemons WM, Brodersen DE, Morgan-Warren RJ, Hartsch T, Wimberly BT, Ramakrishnan V. Crystal structure of an initiation factor bound to the 30S ribosomal subunit. Science. 2001 Jan 19; 291(5503):498-501. PMID: 11228145.
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Brodersen DE, Carter AP, Clemons WM, Morgan-Warren RJ, Murphy FV, Ogle JM, Tarry MJ, Wimberly BT, Ramakrishnan V. Atomic structures of the 30S subunit and its complexes with ligands and antibiotics. Cold Spring Harb Symp Quant Biol. 2001; 66:17-32. PMID: 12762005.
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Brodersen DE, Clemons WM, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell. 2000 Dec 22; 103(7):1143-54. PMID: 11163189.
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Carter AP, Clemons WM, Brodersen DE, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature. 2000 Sep 21; 407(6802):340-8. PMID: 11014183.
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Wimberly BT, Brodersen DE, Clemons WM, Morgan-Warren RJ, Carter AP, Vonrhein C, Hartsch T, Ramakrishnan V. Structure of the 30S ribosomal subunit. Nature. 2000 Sep 21; 407(6802):327-39. PMID: 11014182.
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Allard P, Rak AV, Wimberly BT, Clemons WM, Kalinin A, Helgstrand M, Garber MB, Ramakrishnan V, Härd T. Another piece of the ribosome: solution structure of S16 and its location in the 30S subunit. Structure. 2000 Aug 15; 8(8):875-82. PMID: 10997906.
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Clemons WM, May JL, Wimberly BT, McCutcheon JP, Capel MS, Ramakrishnan V. Structure of a bacterial 30S ribosomal subunit at 5.5 A resolution. Nature. 1999 Aug 26; 400(6747):833-40. PMID: 10476960.
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Wimberly BT, Guymon R, McCutcheon JP, White SW, Ramakrishnan V. A detailed view of a ribosomal active site: the structure of the L11-RNA complex. Cell. 1999 May 14; 97(4):491-502. PMID: 10338213.
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Wimberly BT, White SW, Ramakrishnan V. The structure of ribosomal protein S7 at 1.9 A resolution reveals a beta-hairpin motif that binds double-stranded nucleic acids. Structure. 1997 Sep 15; 5(9):1187-98. PMID: 9331418.
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Wimberly B. A common RNA loop motif as a docking module and its function in the hammerhead ribozyme. Nat Struct Biol. 1994 Nov; 1(11):820-7. PMID: 7543360.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 1997 | 1 | | 1999 | 2 | | 2000 | 4 | | 2001 | 3 | | 2002 | 1 | | 2003 | 1 | | 2009 | 1 | | 2014 | 1 | | 2016 | 1 | | 2017 | 1 | | 2024 | 2 | | 2025 | 1 |
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