 DNA Fragmentation
"DNA Fragmentation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Splitting the DNA into shorter pieces by endonucleolytic DNA CLEAVAGE at multiple sites. It includes the internucleosomal DNA fragmentation, which along with chromatin condensation, are considered to be the hallmarks of APOPTOSIS.
| Descriptor ID |
D053938
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| MeSH Number(s) |
G05.200.230
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "DNA Fragmentation".
Below are MeSH descriptors whose meaning is more specific than "DNA Fragmentation".
This graph shows the total number of publications written about "DNA Fragmentation" by people in this website by year, and whether "DNA Fragmentation" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 1 | 2 | | 1999 | 0 | 3 | 3 | | 2000 | 0 | 2 | 2 | | 2001 | 2 | 2 | 4 | | 2002 | 0 | 2 | 2 | | 2004 | 0 | 6 | 6 | | 2005 | 0 | 1 | 1 | | 2006 | 1 | 2 | 3 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 3 | 3 | | 2009 | 0 | 3 | 3 | | 2010 | 1 | 2 | 3 | | 2011 | 0 | 1 | 1 | | 2012 | 0 | 2 | 2 | | 2013 | 0 | 1 | 1 | | 2014 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "DNA Fragmentation" by people in Profiles.
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Das D, Fayazzadeh E, Li X, Koirala N, Wadera A, Lang M, Zernic M, Panick C, Nesbitt P, McLennan G. Quiescent hepatic stellate cells induce toxicity and sensitivity to doxorubicin in cancer cells through a caspase-independent cell death pathway: Central role of apoptosis-inducing factor. J Cell Physiol. 2020 09; 235(9):6167-6182.
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Ohm AM, Tan AC, Heasley LE, Reyland ME. Co-dependency of PKCd and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer. Oncogene. 2017 07 27; 36(30):4370-4378.
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Conradt B, Wu YC, Xue D. Programmed Cell Death During Caenorhabditis elegans Development. Genetics. 2016 08; 203(4):1533-62.
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Bahr B, Galan HL, Arroyo JA. Decreased expression of phosphorylated placental heat shock protein 27 in human and ovine intrauterine growth restriction (IUGR). Placenta. 2014 Jun; 35(6):404-10.
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Gridley DS, Mao XW, Stodieck LS, Ferguson VL, Bateman TA, Moldovan M, Cunningham CE, Jones TA, Slater JM, Pecaut MJ. Changes in mouse thymus and spleen after return from the STS-135 mission in space. PLoS One. 2013; 8(9):e75097.
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Leopoldino AM, Squarize CH, Garcia CB, Almeida LO, Pestana CR, Sobral LM, Uyemura SA, Tajara EH, Silvio Gutkind J, Curti C. SET protein accumulates in HNSCC and contributes to cell survival: antioxidant defense, Akt phosphorylation and AVOs acidification. Oral Oncol. 2012 Nov; 48(11):1106-13.
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Arruda DC, Santos LC, Melo FM, Pereira FV, Figueiredo CR, Matsuo AL, Mortara RA, Juliano MA, Rodrigues EG, Dobroff AS, Polonelli L, Travassos LR. ?-Actin-binding complementarity-determining region 2 of variable heavy chain from monoclonal antibody C7 induces apoptosis in several human tumor cells and is protective against metastatic melanoma. J Biol Chem. 2012 Apr 27; 287(18):14912-22.
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Menke C, Bin L, Thorburn J, Behbakht K, Ford HL, Thorburn A. Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents. Cancer Res. 2011 Mar 01; 71(5):1883-92.
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Harry BL, Nakagawa A, Xue D. Dicing up chromosomes: the unexpected role of Dicer in apoptosis. Cell Cycle. 2010 Dec 15; 9(24):4772-3.
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Hail N, Chen P, Wempe MF. The hydroxyl functional group of N-(4-hydroxyphenyl)retinamide mediates cellular uptake and cytotoxicity in premalignant and malignant human epithelial cells. Free Radic Biol Med. 2010 Dec 15; 49(12):2001-9.
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