 Dantrolene
"Dantrolene" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.
| Descriptor ID |
D003620
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| MeSH Number(s) |
D03.383.129.308.432.555.287
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Dantrolene".
Below are MeSH descriptors whose meaning is more specific than "Dantrolene".
This graph shows the total number of publications written about "Dantrolene" by people in this website by year, and whether "Dantrolene" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2009 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Dantrolene" by people in Profiles.
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Farkhondeh T, Roshanravan B, Shirazi FM, Mehrpour O. Can dantrolene be used in the treatment of cardioglycosides poisonings? Expert Opin Drug Metab Toxicol. 2021 Jan; 17(1):1-2.
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Litman RS, Smith VI, Larach MG, Mayes L, Shukry M, Theroux MC, Watt S, Wong CA. Consensus Statement of the Malignant Hyperthermia Association of the United States on Unresolved Clinical Questions Concerning the Management of Patients With Malignant Hyperthermia. Anesth Analg. 2019 04; 128(4):652-659.
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Larach MG, Klumpner TT, Brandom BW, Vaughn MT, Belani KG, Herlich A, Kim TW, Limoncelli J, Riazi S, Sivak EL, Capacchione J, Mashman D, Kheterpal S, Kooij F, Wilczak J, Soto R, Berris J, Price Z, Lins S, Coles P, Harris JM, Cummings KC, Berman MF, Nanamori M, Adelman BT, Wedeven C, LaGorio J, McCormick PJ, Tom S, Aziz MF, Coffman T, Ellis TA, Molina S, Peterson W, Mackey SC, van Klei WA, Ginde AA, Biggs DA, Neuman MD, Craft RM, Pace NL, Paganelli WC, Durieux ME, Nair BJ, Wanderer JP, Miller SA, Helsten DL, Turnbull ZA, Schonberger RB. Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review. Anesthesiology. 2019 01; 130(1):41-54.
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Muehlschlegel S, Carandang R, Hall W, Kini N, Izzy S, Garland B, Ouillette C, van der Bom IM, Flood TF, Gounis MJ, Weaver JP, Barton B, Wakhloo AK. Dantrolene for cerebral vasospasm after subarachnoid haemorrhage: a randomised double blind placebo-controlled safety trial. J Neurol Neurosurg Psychiatry. 2015 Sep; 86(9):1029-35.
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Bannister RA. Dantrolene-induced inhibition of skeletal L-type Ca2+ current requires RyR1 expression. Biomed Res Int. 2013; 2013:390493.
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Husain SZ, Orabi AI, Muili KA, Luo Y, Sarwar S, Mahmood SM, Wang D, Choo-Wing R, Singh VP, Parness J, Ananthanaravanan M, Bhandari V, Perides G. Ryanodine receptors contribute to bile acid-induced pathological calcium signaling and pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15; 302(12):G1423-33.
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Matthews DJ, Balaban B. [Management of spasticity in children with cerebral palsy]. Acta Orthop Traumatol Turc. 2009 Mar-Apr; 43(2):81-6.
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Bannister RA, Pessah IN, Beam KG. The skeletal L-type Ca(2+) current is a major contributor to excitation-coupled Ca(2+) entry. J Gen Physiol. 2009 Jan; 133(1):79-91.
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Kramer RE. Angiotensin II-stimulated changes in calcium metabolism in cultured glomerulosa cells. Mol Cell Endocrinol. 1988 Dec; 60(2-3):199-210.
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Metz SA, Draznin B, Sussman KE, Leitner JW. Unmasking of arachidonate-induced insulin release by removal of extracellular calcium. Arachidonic acid mobilizes cellular calcium in rat islets of Langerhans. Biochem Biophys Res Commun. 1987 Jan 15; 142(1):251-8.
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