 Phenytoin
"Phenytoin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
| Descriptor ID |
D010672
|
| MeSH Number(s) |
D03.383.129.308.432.555.730
|
| Concept/Terms |
Phenytoin- Phenytoin
- 5,5-Diphenylhydantoin
- Fenitoin
- 5,5-diphenylimidazolidine-2,4-dione
- Diphenylhydantoin
Phenytoin Sodium- Phenytoin Sodium
- Sodium Diphenylhydantoinate
- Diphenylhydantoinate, Sodium
|
Below are MeSH descriptors whose meaning is more general than "Phenytoin".
Below are MeSH descriptors whose meaning is more specific than "Phenytoin".
This graph shows the total number of publications written about "Phenytoin" by people in this website by year, and whether "Phenytoin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 | | 2004 | 0 | 1 | 1 | | 2006 | 0 | 1 | 1 | | 2012 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Phenytoin" by people in Profiles.
-
Mu?oz-Pichuante D, Villa Zapata L, Cabrera S, Lagos X, Grandjean J. Dosage of phenytoin in neurocritical patients using Bayesian algorithms: a pilot study. Drug Metab Pers Ther. 2019 12 18; 34(4).
-
Parikh L, MacLaren R. The predictive performances of equations used to estimate unbound phenytoin concentrations in a medical ICU population and the impact of exogenous albumin administration. J Crit Care. 2018 04; 44:95-100.
-
Dong MM, Trenholm R, Rosario-Ortiz FL. Photochemical degradation of atenolol, carbamazepine, meprobamate, phenytoin and primidone in wastewater effluents. J Hazard Mater. 2015 Jan 23; 282:216-23.
-
Pieracci FM, Moore EE, Beauchamp K, Tebockhorst S, Barnett CC, Bensard DD, Burlew CC, Biffl WL, Stoval RT, Johnson JL. A cost-minimization analysis of phenytoin versus levetiracetam for early seizure pharmacoprophylaxis after traumatic brain injury. J Trauma Acute Care Surg. 2012 Jan; 72(1):276-81.
-
Barron MA, Doyle J, Zlotkin S. Vitamin K deficiency in children pre-bone marrow transplantation. Bone Marrow Transplant. 2006 Jan; 37(2):151-4.
-
Stanford MS, Helfritz LE, Conklin SM, Villemarette-Pittman NR, Greve KW, Adams D, Houston RJ. A comparison of anticonvulsants in the treatment of impulsive aggression. Exp Clin Psychopharmacol. 2005 Feb; 13(1):72-7.
-
Rumack BH. Acetaminophen misconceptions. Hepatology. 2004 Jul; 40(1):10-5.
-
Todorovic SM, Rastogi AJ, Jevtovic-Todorovic V. Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats. Br J Pharmacol. 2003 Sep; 140(2):255-60.
-
Rumack BH. Acetaminophen hepatotoxicity: the first 35 years. J Toxicol Clin Toxicol. 2002; 40(1):3-20.
-
Todorovic SM, Perez-Reyes E, Lingle CJ. Anticonvulsants but not general anesthetics have differential blocking effects on different T-type current variants. Mol Pharmacol. 2000 Jul; 58(1):98-108.
|
People  People who have written about this concept. _
Similar Concepts
People who have written about this concept.
_
Top Journals
Top journals in which articles about this concept have been published.
|