 Quinidine
"Quinidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
| Descriptor ID |
D011802
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| MeSH Number(s) |
D03.132.206.636 D03.605.687.637 D03.633.100.810.699
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Quinidine".
Below are MeSH descriptors whose meaning is more specific than "Quinidine".
This graph shows the total number of publications written about "Quinidine" by people in this website by year, and whether "Quinidine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 |
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Below are the most recent publications written about "Quinidine" by people in Profiles.
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Jutabha P, Wempe MF, Anzai N, Otomo J, Kadota T, Endou H. Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux. Pharmacol Res. 2010 Jan; 61(1):76-84.
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Panitch HS, Thisted RA, Smith RA, Wynn DR, Wymer JP, Achiron A, Vollmer TL, Mandler RN, Dietrich DW, Fletcher M, Pope LE, Berg JE, Miller A. Randomized, controlled trial of dextromethorphan/quinidine for pseudobulbar affect in multiple sclerosis. Ann Neurol. 2006 May; 59(5):780-7.
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Sano Y, Inamura K, Miyake A, Mochizuki S, Kitada C, Yokoi H, Nozawa K, Okada H, Matsushime H, Furuichi K. A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord. J Biol Chem. 2003 Jul 25; 278(30):27406-12.
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Miyake A, Mochizuki S, Yokoi H, Kohda M, Furuichi K. New ether-?-go-go K(+) channel family members localized in human telencephalon. J Biol Chem. 1999 Aug 27; 274(35):25018-25.
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Stelzner TJ, Welsh CH, Berger E, McCullough RG, Morris K, Repine JE, Weil JV. Antiarrhythmic agents diminish thiourea-induced pulmonary vascular protein leak in rats. J Appl Physiol (1985). 1987 Nov; 63(5):1877-83.
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Kikendall JW, Friedman AC, Oyewole MA, Fleischer D, Johnson LF. Pill-induced esophageal injury. Case reports and review of the medical literature. Dig Dis Sci. 1983 Feb; 28(2):174-82.
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Szefler SJ, Pieroni DR, Gingell RL, Shen DD. Rapid elimination of quinidine in pediatric patients. Pediatrics. 1982 Sep; 70(3):370-5.
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Hammermeister KE, Boerth RC, Warbasse JR. The comparative inotropic effects of six clinically used antiarrhythmic agents. Am Heart J. 1972 Nov; 84(5):643-52.
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