 Hexamethonium
"Hexamethonium" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nicotinic cholinergic antagonist often referred to as the prototypical ganglionic blocker. It is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. It has been used for a variety of therapeutic purposes including hypertension but, like the other ganglionic blockers, it has been replaced by more specific drugs for most purposes, although it is widely used a research tool.
| Descriptor ID |
D018738
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| MeSH Number(s) |
D02.092.877.250.592.400 D02.675.276.558.592.500
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Hexamethonium".
Below are MeSH descriptors whose meaning is more specific than "Hexamethonium".
This graph shows the total number of publications written about "Hexamethonium" by people in this website by year, and whether "Hexamethonium" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 | | 2010 | 0 | 1 | 1 |
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Below are the most recent publications written about "Hexamethonium" by people in Profiles.
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Ortiz NC, O'Neill HC, Marks MJ, Grady SR. Varenicline blocks ?2*-nAChR-mediated response and activates ?4*-nAChR-mediated responses in mice in vivo. Nicotine Tob Res. 2012 Jun; 14(6):711-9.
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Papke RL, Wecker L, Stitzel JA. Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther. 2010 May; 333(2):501-18.
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Greyson C, Xu Y, Lu L, Schwartz GG. Right ventricular pressure and dilation during pressure overload determine dysfunction after pressure overload. Am J Physiol Heart Circ Physiol. 2000 May; 278(5):H1414-20.
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Szarek JL, Gillespie MN, Altiere RJ, Diamond L. Reflex activation of the nonadrenergic noncholinergic inhibitory nervous system in feline airways. Am Rev Respir Dis. 1986 Jun; 133(6):1159-62.
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