 Phorbol 12,13-Dibutyrate
"Phorbol 12,13-Dibutyrate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phorbol ester found in CROTON OIL which, in addition to being a potent skin tumor promoter, is also an effective activator of calcium-activated, phospholipid-dependent protein kinase (protein kinase C). Due to its activation of this enzyme, phorbol 12,13-dibutyrate profoundly affects many different biological systems.
| Descriptor ID |
D015240
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| MeSH Number(s) |
D02.455.849.291.500.510.700
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| Concept/Terms |
Phorbol 12,13-Dibutyrate- Phorbol 12,13-Dibutyrate
- 12,13-Dibutyrate, Phorbol
- Phorbol-12,13-Dibutyrate
- Phorbol 12,13 Dibutyrate
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Below are MeSH descriptors whose meaning is more general than "Phorbol 12,13-Dibutyrate".
Below are MeSH descriptors whose meaning is more specific than "Phorbol 12,13-Dibutyrate".
This graph shows the total number of publications written about "Phorbol 12,13-Dibutyrate" by people in this website by year, and whether "Phorbol 12,13-Dibutyrate" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 1 | 2 | | 1996 | 0 | 1 | 1 | | 2000 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phorbol 12,13-Dibutyrate" by people in Profiles.
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Hypolite JA, Chang S, Wein AJ, Chacko S, Malykhina AP. Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms. BMC Urol. 2015 Apr 21; 15:34.
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Ahern GP, Brooks IM, Miyares RL, Wang XB. Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. J Neurosci. 2005 May 25; 25(21):5109-16.
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Rabbani M, Tabakoff B. Chronic ethanol treatment reduces adenylyl cyclase activity in human erythroleukemia cells. Eur J Pharmacol. 2001 Oct 26; 430(1):19-23.
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Varkevisser B, Kinnamon SC. Sweet taste transduction in hamster: role of protein kinases. J Neurophysiol. 2000 May; 83(5):2526-32.
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Rabbani M, Nelson EJ, Hoffman PL, Tabakoff B. Role of protein kinase C in ethanol-induced activation of adenylyl cyclase. Alcohol Clin Exp Res. 1999 Jan; 23(1):77-86.
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Fujihara H, Walker LA, Gong MC, Lemichez E, Boquet P, Somlyo AV, Somlyo AP. Inhibition of RhoA translocation and calcium sensitization by in vivo ADP-ribosylation with the chimeric toxin DC3B. Mol Biol Cell. 1997 Dec; 8(12):2437-47.
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Gong MC, Fujihara H, Walker LA, Somlyo AV, Somlyo AP. Down-regulation of G-protein-mediated Ca2+ sensitization in smooth muscle. Mol Biol Cell. 1997 Feb; 8(2):279-86.
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Prekeris R, Mayhew MW, Cooper JB, Terrian DM. Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function. J Cell Biol. 1996 Jan; 132(1-2):77-90.
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Charlesworth A, Rozengurt E. Thapsigargin and di-tert-butylhydroquinone induce synergistic stimulation of DNA synthesis with phorbol ester and bombesin in Swiss 3T3 cells. J Biol Chem. 1994 Dec 23; 269(51):32528-35.
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Graham IL, Anderson DC, Holers VM, Brown EJ. Complement receptor 3 (CR3, Mac-1, integrin alpha M beta 2, CD11b/CD18) is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils. J Cell Biol. 1994 Nov; 127(4):1139-47.
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