Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution
Menu

Contact Us
If you have any questions or feedback please contact us.

Anna Malykhina

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-SRG

    Collapse Research 
    Collapse research activities and funding
    R01DK116648     (MALYKHINA, ANNA P)Sep 8, 2020 - Jun 30, 2024
    NIH
    Mechanisms of neurogenic bladder dysfunction in a viral murine model of multiple sclerosis
    Role: Principal Investigator
    R01DK121506     (MALYKHINA, ANNA P)Aug 1, 2019 - May 31, 2022
    NIH
    Regulation of pelvic pain and micturition reflex by VEGF in urological chronic pelvic pain syndrome
    Role: Principal Investigator
    R01DK095817     (MALYKHINA, ANNA P)Sep 8, 2014 - May 31, 2020
    NIH
    Role of Mechanotransduction in detrusor over activity
    Role: Principal Investigator
    P20DK097819     (MALYKHINA, ANNA P.)Sep 29, 2012 - Jul 31, 2015
    NIH
    Neurogenic bladder dysfunctions in neurological disorders
    Role: Principal Investigator
    R01DK077699     (MALYKHINA, ANNA P.)Jul 1, 2008 - Apr 30, 2015
    NIH
    Cross-sensitization in the pelvis and neurogenic bladder
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Iguchi N, D?nmez MI, Malykhina AP, Wilcox DT. Anti-fibrotic effect of tocotrienols for bladder dysfunction due to partial bladder outlet obstruction. Investig Clin Urol. 2023 03; 64(2):189-196. PMID: 36882179.
      View in: PubMed
    2. Clarkson TC, Iguchi N, Xie AX, Malykhina AP. Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus. PLoS One. 2022; 17(12):e0278918. PMID: 36490282.
      View in: PubMed
    3. Iguchi N, Hecht SL, Gao D, Wilcox DT, Malykhina AP, Cost NG. Sexual dimorphic impacts of systemic vincristine on lower urinary tract function. Sci Rep. 2022 03 24; 12(1):5113. PMID: 35332157.
      View in: PubMed
    4. Xie AX, Iguchi N, Clarkson TC, Malykhina AP. Pharmacogenetic inhibition of lumbosacral sensory neurons alleviates visceral hypersensitivity in a mouse model of chronic pelvic pain. PLoS One. 2022; 17(1):e0262769. PMID: 35077502.
      View in: PubMed
    5. Hecht SL, Quach A, Gao D, Brazell A, Beltran G, Holbrook S, Gore L, Iguchi N, Malykhina A, Wilcox D, Cost NG. A prospective survey study of lower urinary tract dysfunction in childhood cancer survivors after vincristine and/or doxorubicin chemotherapy. Pediatr Blood Cancer. 2021 10; 68(10):e29226. PMID: 34245214.
      View in: PubMed
    6. Iguchi N, Carrasco A, Xie AX, Pineda RH, Malykhina AP, Wilcox DT. Functional constipation induces bladder overactivity associated with upregulations of Htr2 and Trpv2 pathways. Sci Rep. 2021 01 13; 11(1):1149. PMID: 33441874.
      View in: PubMed
    7. Xie AX, Madayag A, Minton SK, McCarthy KD, Malykhina AP. Sensory satellite glial Gq-GPCR activation alleviates inflammatory pain via peripheral adenosine 1 receptor activation. Sci Rep. 2020 08 25; 10(1):14181. PMID: 32843670.
      View in: PubMed
    8. Smith AL, Weissbart SJ, Hartigan SM, Bilello M, Newman DK, Wein AJ, Malykhina AP, Erus G, Fan Y. Association between urinary symptom severity and white matter plaque distribution in women with multiple sclerosis. Neurourol Urodyn. 2020 01; 39(1):339-346. PMID: 31691357.
      View in: PubMed
    9. Lee S, Nedumaran B, Hypolite J, Caldwell B, Rudolph MC, Malykhina AP. Differential neurodegenerative phenotypes are associated with heterogeneous voiding dysfunction in a coronavirus-induced model of multiple sclerosis. Sci Rep. 2019 07 26; 9(1):10869. PMID: 31350464.
      View in: PubMed
    10. Pineda RH, Hypolite J, Lee S, Carrasco A, Iguchi N, Meacham RB, Malykhina AP. Altered detrusor contractility and voiding patterns in mice lacking the mechanosensitive TREK-1 channel. BMC Urol. 2019 May 21; 19(1):40. PMID: 31113422.
      View in: PubMed
    11. Iguchi N, D?nmez MI, Carrasco A, Wilcox DT, Pineda RH, Malykhina AP, Cost NG. Doxorubicin induces detrusor smooth muscle impairments through myosin dysregulation, leading to a risk of lower urinary tract dysfunction. Am J Physiol Renal Physiol. 2019 07 01; 317(1):F197-F206. PMID: 31066574.
      View in: PubMed
    12. Xie AX, Pan XQ, Meacham RB, Malykhina AP. The Expression of Transcription Factors Mecp2 and CREB Is Modulated in Inflammatory Pelvic Pain. Front Syst Neurosci. 2018; 12:69. PMID: 30687029.
      View in: PubMed
    13. Nedumaran B, Pineda RH, Rudra P, Lee S, Malykhina AP. Association of genetic polymorphisms in the pore domains of mechano-gated TREK-1 channel with overactive lower urinary tract symptoms in humans. Neurourol Urodyn. 2019 01; 38(1):144-150. PMID: 30350878.
      View in: PubMed
    14. Iguchi N, Malykhina AP, Wilcox DT. Early life voiding dysfunction leads to lower urinary tract dysfunction through alteration of muscarinic and purinergic signaling in the bladder. Am J Physiol Renal Physiol. 2018 11 01; 315(5):F1320-F1328. PMID: 30089034.
      View in: PubMed
    15. Malykhina AP. How the brain controls urination. Elife. 2017 12 04; 6. PMID: 29199949.
      View in: PubMed
    16. Lee S, Carrasco A, Meacham RB, Malykhina AP. Transurethral Instillation Procedure in Adult Male Mouse. J Vis Exp. 2017 11 02; (129). PMID: 29155777.
      View in: PubMed
    17. Nedumaran B, Rudra P, Gaydos J, Kumar S, Meacham RB, Burnham EL, Malykhina AP. Impact of Regular Cannabis Use on Biomarkers of Lower Urinary Tract Function. Urology. 2017 Nov; 109:223.e9-223.e16. PMID: 28827195.
      View in: PubMed
    18. Iguchi N, D?nmez MI, Malykhina AP, Carrasco A, Wilcox DT. Preventative effects of a HIF inhibitor, 17-DMAG, on partial bladder outlet obstruction-induced bladder dysfunction. Am J Physiol Renal Physiol. 2017 Nov 01; 313(5):F1149-F1160. PMID: 28768664.
      View in: PubMed
    19. Pineda RH, Nedumaran B, Hypolite J, Pan XQ, Wilson S, Meacham RB, Malykhina AP. Altered expression and modulation of the two-pore-domain (K2P) mechanogated potassium channel TREK-1 in overactive human detrusor. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F535-F546. PMID: 28539337.
      View in: PubMed
    20. Lee S, Malykhina AP. Neuro-tracing approach to study kidney innervation: a technical note. Kidney Res Clin Pract. 2017 Mar; 36(1):86-94. PMID: 28393001.
      View in: PubMed
    21. Richter HE, Moalli P, Amundsen CL, Malykhina AP, Wallace D, Rogers R, Myers D, Paraiso M, Albo M, Shi H, Nolen T, Meikle S, Word RA. Urinary Biomarkers in Women with Refractory Urgency Urinary Incontinence Randomized to Sacral Neuromodulation versus OnabotulinumtoxinA Compared to Controls. J Urol. 2017 06; 197(6):1487-1495. PMID: 28089729.
      View in: PubMed
    22. Malykhina AP, Brodie KE, Wilcox DT. Genitourinary and gastrointestinal co-morbidities in children: The role of neural circuits in regulation of visceral function. J Pediatr Urol. 2017 Apr; 13(2):177-182. PMID: 28392009.
      View in: PubMed
    23. Pennycuff JF, Schutte SC, Hudson CO, Karp DR, Malykhina AP, Northington GM. Urinary neurotrophic peptides in postmenopausal women with and without overactive bladder. Neurourol Urodyn. 2017 03; 36(3):740-744. PMID: 27062604.
      View in: PubMed
    24. Smith AL, Hantsoo L, Malykhina AP, File DW, Valentino R, Wein AJ, Sammel MD, Epperson CN. Basal and stress-activated hypothalamic pituitary adrenal axis function in postmenopausal women with overactive bladder. Int Urogynecol J. 2016 Sep; 27(9):1383-91. PMID: 26942596.
      View in: PubMed
    25. Iguchi N, Malykhina AP, Wilcox DT. Inhibition of HIF Reduces Bladder Hypertrophy and Improves Bladder Function in Murine Model of Partial Bladder Outlet Obstruction. J Urol. 2016 Apr; 195(4 Pt 2):1250-6. PMID: 26926557.
      View in: PubMed
    26. Weissbart SJ, Pechersky D, Malykhina A, Bavaria T, Parrillo L, Arya LA, Bilello M, Wein AJ, Smith AL. The impact of pontine disease on lower urinary tract symptoms in patients with multiple sclerosis. Neurourol Urodyn. 2017 02; 36(2):453-456. PMID: 26741487.
      View in: PubMed
    27. Hypolite JA, Malykhina AP. Regulation of urinary bladder function by protein kinase C in physiology and pathophysiology. BMC Urol. 2015 Nov 04; 15:110. PMID: 26538012.
      View in: PubMed
    28. Hypolite JA, Chang S, Wein AJ, Chacko S, Malykhina AP. Protein kinase C modulates frequency of micturition and non-voiding contractions in the urinary bladder via neuronal and myogenic mechanisms. BMC Urol. 2015 Apr 21; 15:34. PMID: 25896919.
      View in: PubMed
    29. Lamarre NS, Braverman AS, Malykhina AP, Barbe MF, Ruggieri MR. Alterations in nerve-evoked bladder contractions in a coronavirus-induced mouse model of multiple sclerosis. PLoS One. 2014; 9(10):e109314. PMID: 25310403.
      View in: PubMed
    30. McMillan MT, Pan XQ, Smith AL, Newman DK, Weiss SR, Ruggieri MR, Malykhina AP. Coronavirus-induced demyelination of neural pathways triggers neurogenic bladder overactivity in a mouse model of multiple sclerosis. Am J Physiol Renal Physiol. 2014 Sep 01; 307(5):F612-22. PMID: 25007876.
      View in: PubMed
    31. Moore KH, Malykhina AP. What is the role of covert infection in detrusor overactivity, and other LUTD? ICI-RS 2013. Neurourol Urodyn. 2014 Jun; 33(5):606-10. PMID: 24844724.
      View in: PubMed
    32. Lei Q, Pan XQ, Chang S, Malkowicz SB, Guzzo TJ, Malykhina AP. Response of the human detrusor to stretch is regulated by TREK-1, a two-pore-domain (K2P) mechano-gated potassium channel. J Physiol. 2014 Jul 15; 592(14):3013-30. PMID: 24801307.
      View in: PubMed
    33. Pan XQ, Malykhina AP. Estrous cycle dependent fluctuations of regulatory neuropeptides in the lower urinary tract of female rats upon colon-bladder cross-sensitization. PLoS One. 2014; 9(5):e94872. PMID: 24788240.
      View in: PubMed
    34. Malykhina A, Hanno P. How are we going to make progress treating bladder pain syndrome? ICI-RS 2013. Neurourol Urodyn. 2014 Jun; 33(5):625-9. PMID: 24615847.
      View in: PubMed
    35. Malykhina AP, Lei Q, Chang S, Pan XQ, Villamor AN, Smith AL, Seftel AD. Bladder outlet obstruction triggers neural plasticity in sensory pathways and contributes to impaired sensitivity in erectile dysfunction. Am J Physiol Regul Integr Comp Physiol. 2013 May 15; 304(10):R837-45. PMID: 23535456.
      View in: PubMed
    36. Lei Q, Pan XQ, Villamor AN, Asfaw TS, Chang S, Zderic SA, Malykhina AP. Lack of transient receptor potential vanilloid 1 channel modulates the development of neurogenic bladder dysfunction induced by cross-sensitization in afferent pathways. J Neuroinflammation. 2013 Jan 11; 10:3. PMID: 23305398.
      View in: PubMed
    37. Hypolite JA, Lei Q, Chang S, Zderic SA, Butler S, Wein AJ, Malykhina AP, Chacko S. Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: involvement of BK channels. Am J Physiol Renal Physiol. 2013 Mar 01; 304(5):F451-62. PMID: 23269650.
      View in: PubMed
    38. Malykhina AP, Lei Q, Erickson CS, Epstein ML, Saban MR, Davis CA, Saban R. VEGF induces sensory and motor peripheral plasticity, alters bladder function, and promotes visceral sensitivity. BMC Physiol. 2012 Dec 19; 12:15. PMID: 23249422.
      View in: PubMed
    39. Malykhina AP, Qin C, Lei Q, Pan XQ, Greenwood-Van Meerveld B, Foreman RD. Differential effects of intravesical resiniferatoxin on excitability of bladder spinal neurons upon colon-bladder cross-sensitization. Brain Res. 2013 Jan 23; 1491:213-24. PMID: 23146715.
      View in: PubMed
    40. Malykhina AP, Wyndaele JJ, Andersson KE, De Wachter S, Dmochowski RR. Do the urinary bladder and large bowel interact, in sickness or in health? ICI-RS 2011. Neurourol Urodyn. 2012 Mar; 31(3):352-8. PMID: 22378593.
      View in: PubMed
    41. Cory L, Harvie HS, Northington G, Malykhina A, Whitmore K, Arya L. Association of neuropathic pain with bladder, bowel and catastrophizing symptoms in women with bladder pain syndrome. J Urol. 2012 Feb; 187(2):503-7. PMID: 22177143.
      View in: PubMed
    42. Arya LA, Northington GM, Asfaw T, Harvie H, Malykhina A. Evidence of bladder oversensitivity in the absence of an infection in premenopausal women with a history of recurrent urinary tract infections. BJU Int. 2012 Jul; 110(2):247-51. PMID: 22129305.
      View in: PubMed
    43. Asfaw TS, Hypolite J, Northington GM, Arya LA, Wein AJ, Malykhina AP. Acute colonic inflammation triggers detrusor instability via activation of TRPV1 receptors in a rat model of pelvic organ cross-sensitization. Am J Physiol Regul Integr Comp Physiol. 2011 Jun; 300(6):R1392-400. PMID: 21474425.
      View in: PubMed
    44. Pan XQ, Gonzalez JA, Chang S, Chacko S, Wein AJ, Malykhina AP. Experimental colitis triggers the release of substance P and calcitonin gene-related peptide in the urinary bladder via TRPV1 signaling pathways. Exp Neurol. 2010 Oct; 225(2):262-73. PMID: 20501335.
      View in: PubMed
    45. Matveev AV, Fitzgerald JB, Xu J, Malykhina AP, Rodgers KK, Ding XQ. The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change. Biochemistry. 2010 Mar 02; 49(8):1628-39. PMID: 20088482.
      View in: PubMed
    46. Ding XQ, Fitzgerald JB, Quiambao AB, Harry CS, Malykhina AP. Molecular pathogenesis of achromatopsia associated with mutations in the cone cyclic nucleotide-gated channel CNGA3 subunit. Adv Exp Med Biol. 2010; 664:245-53. PMID: 20238023.
      View in: PubMed
    47. Noronha R, Akbarali H, Malykhina A, Foreman RD, Greenwood-Van Meerveld B. Changes in urinary bladder smooth muscle function in response to colonic inflammation. Am J Physiol Renal Physiol. 2007 Nov; 293(5):F1461-7. PMID: 17715261.
      View in: PubMed
    48. Ross GR, Kang M, Shirwany N, Malykhina AP, Drozd M, Akbarali HI. Nitrotyrosylation of Ca2+ channels prevents c-Src kinase regulation of colonic smooth muscle contractility in experimental colitis. J Pharmacol Exp Ther. 2007 Sep; 322(3):948-56. PMID: 17551092.
      View in: PubMed
    49. Malykhina AP, Qin C, Greenwood-van Meerveld B, Foreman RD, Lupu F, Akbarali HI. Hyperexcitability of convergent colon and bladder dorsal root ganglion neurons after colonic inflammation: mechanism for pelvic organ cross-talk. Neurogastroenterol Motil. 2006 Oct; 18(10):936-48. PMID: 16961697.
      View in: PubMed
    50. Clark RM, De Biase I, Malykhina AP, Al-Mahdawi S, Pook M, Bidichandani SI. The GAA triplet-repeat is unstable in the context of the human FXN locus and displays age-dependent expansions in cerebellum and DRG in a transgenic mouse model. Hum Genet. 2007 Jan; 120(5):633-40. PMID: 17024371.
      View in: PubMed
    51. Qin C, Malykhina AP, Akbarali HI, Foreman RD. Cross-organ sensitization of lumbosacral spinal neurons receiving urinary bladder input in rats with inflamed colon. Gastroenterology. 2005 Dec; 129(6):1967-78. PMID: 16344065.
      View in: PubMed
    52. Malykhina AP, Akbarali HI. Inflammation-induced "channelopathies" in the gastrointestinal smooth muscle. Cell Biochem Biophys. 2004; 41(2):319-30. PMID: 15475616.
      View in: PubMed
    Malykhina's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (278) concept(s)
    _
    Co-Authors Expand Description
    See all (10) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2024 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)