 Potassium Channels, Tandem Pore Domain
"Potassium Channels, Tandem Pore Domain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Potassium channels that contain two pores in tandem. They are responsible for baseline or leak currents and may be the most numerous of all K channels.
| Descriptor ID |
D024683
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| MeSH Number(s) |
D12.776.157.530.400.600.850 D12.776.543.550.450.750.850 D12.776.543.585.400.750.850
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| Concept/Terms |
Potassium Channels, Tandem Pore Domain- Potassium Channels, Tandem Pore Domain
- Potassium Channels, Leak
- Leak Potassium Channels
- Potassium Channels, Baseline
- Baseline Potassium Channels
- K+ Channels, Tandem Pore Domain
- Potassium Channel, Baseline
- Baseline Potassium Channel
- Potassium Channel, Tandem Pore Domain
- Tandem Pore Domain Potassium Channel
- Potassium Channel, Leak
- Leak Potassium Channel
- Potassium Channel, Background
- Background Potassium Channel
- Potassium Channels, Background
- Background Potassium Channels
- Tandem Pore Domain Potassium Channels
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Below are MeSH descriptors whose meaning is more general than "Potassium Channels, Tandem Pore Domain".
Below are MeSH descriptors whose meaning is more specific than "Potassium Channels, Tandem Pore Domain".
This graph shows the total number of publications written about "Potassium Channels, Tandem Pore Domain" by people in this website by year, and whether "Potassium Channels, Tandem Pore Domain" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 1 | 1 | | 2012 | 0 | 1 | 1 | | 2014 | 1 | 1 | 2 | | 2017 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Potassium Channels, Tandem Pore Domain" by people in Profiles.
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Xie AX, Iguchi N, Malykhina AP. Long-term follow-up of TREK-1 KO mice reveals the development of bladder hypertrophy and impaired bladder smooth muscle contractility with age. Am J Physiol Renal Physiol. 2024 Jun 01; 326(6):F957-F970.
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West JD, Austin ED, Rizzi EM, Yan L, Tanjore H, Crabtree AL, Moore CS, Muthian G, Carrier EJ, Jacobson DA, Hamid R, Kendall PL, Majka S, Rathinasabapathy A. KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models. Int J Mol Sci. 2021 May 09; 22(9).
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Pineda RH, Hypolite J, Lee S, Carrasco A, Iguchi N, Meacham RB, Malykhina AP. Altered detrusor contractility and voiding patterns in mice lacking the mechanosensitive TREK-1 channel. BMC Urol. 2019 May 21; 19(1):40.
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Nedumaran B, Pineda RH, Rudra P, Lee S, Malykhina AP. Association of genetic polymorphisms in the pore domains of mechano-gated TREK-1 channel with overactive lower urinary tract symptoms in humans. Neurourol Urodyn. 2019 01; 38(1):144-150.
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Nematian-Ardestani E, Jarerattanachat V, Aryal P, Sansom MSP, Tucker SJ. The effects of stretch activation on ionic selectivity of the TREK-2 K2P K+ channel. Channels (Austin). 2017 Sep 03; 11(5):482-486.
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Pineda RH, Nedumaran B, Hypolite J, Pan XQ, Wilson S, Meacham RB, Malykhina AP. Altered expression and modulation of the two-pore-domain (K2P) mechanogated potassium channel TREK-1 in overactive human detrusor. Am J Physiol Renal Physiol. 2017 Aug 01; 313(2):F535-F546.
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Aryal P, Jarerattanachat V, Clausen MV, Schewe M, McClenaghan C, Argent L, Conrad LJ, Dong YY, Pike ACW, Carpenter EP, Baukrowitz T, Sansom MSP, Tucker SJ. Bilayer-Mediated Structural Transitions Control Mechanosensitivity of the TREK-2 K2P Channel. Structure. 2017 05 02; 25(5):708-718.e2.
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McClenaghan C, Schewe M, Aryal P, Carpenter EP, Baukrowitz T, Tucker SJ. Polymodal activation of the TREK-2 K2P channel produces structurally distinct open states. J Gen Physiol. 2016 06; 147(6):497-505.
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Hardin M, Cho MH, McDonald ML, Wan E, Lomas DA, Coxson HO, MacNee W, Vestbo J, Yates JC, Agusti A, Calverley PM, Celli B, Crim C, Rennard S, Wouters E, Bakke P, Bhatt SP, Kim V, Ramsdell J, Regan EA, Make BJ, Hokanson JE, Crapo JD, Beaty TH, Hersh CP. A genome-wide analysis of the response to inhaled ?2-agonists in chronic obstructive pulmonary disease. Pharmacogenomics J. 2016 08; 16(4):326-35.
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Trick JL, Aryal P, Tucker SJ, Sansom MS. Molecular simulation studies of hydrophobic gating in nanopores and ion channels. Biochem Soc Trans. 2015 Apr; 43(2):146-50.
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