 Phenobarbital
"Phenobarbital" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
| Descriptor ID |
D010634
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| MeSH Number(s) |
D03.383.742.698.253.650
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| Concept/Terms |
Phenobarbital- Phenobarbital
- Phenylbarbital
- Phenylethylbarbituric Acid
- Acid, Phenylethylbarbituric
- Phenemal
- Phenobarbitone
Phenobarbital Sodium- Phenobarbital Sodium
- Sodium, Phenobarbital
- Phenobarbital, Monosodium Salt
- Monosodium Salt Phenobarbital
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Below are MeSH descriptors whose meaning is more general than "Phenobarbital".
Below are MeSH descriptors whose meaning is more specific than "Phenobarbital".
This graph shows the total number of publications written about "Phenobarbital" by people in this website by year, and whether "Phenobarbital" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2005 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 | | 2018 | 2 | 0 | 2 | | 2019 | 1 | 0 | 1 | | 2021 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phenobarbital" by people in Profiles.
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Terasaki D, Kulick B, Calcaterra S, Ray L. Phenobarbital for alcohol withdrawal in the context of the opioid epidemic: a neglected caveat. Addiction. 2023 07; 118(7):1198-1200.
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Lebin JA, Mudan A, Murphy CE, Wang RC, Smollin CG. Return Encounters in Emergency Department Patients Treated with Phenobarbital Versus Benzodiazepines for Alcohol Withdrawal. J Med Toxicol. 2022 01; 18(1):4-10.
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Nelson AC, Kehoe J, Sankoff J, Mintzer D, Taub J, Kaucher KA. Benzodiazepines vs barbiturates for alcohol withdrawal: Analysis of 3 different treatment protocols. Am J Emerg Med. 2019 04; 37(4):733-736.
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Grinspan ZM, Shellhaas RA, Coryell J, Sullivan JE, Wirrell EC, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ, Millichap J, Berg AT. Comparative Effectiveness of Levetiracetam vs Phenobarbital for Infantile Epilepsy. JAMA Pediatr. 2018 04 01; 172(4):352-360.
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Nelson AC, Kaucher KA, Sankoff J, Mintzer D, Taub J, Kehoe J. Incorporating phenobarbital into your symptom-based benzodiazepine alcohol withdrawal protocol in the emergency department. Am J Emerg Med. 2018 11; 36(11):2120-2121.
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Sampath D, Valdez R, White AM, Raol YH. Anticonvulsant effect of flupirtine in an animal model of neonatal hypoxic-ischemic encephalopathy. Neuropharmacology. 2017 Sep 01; 123:126-135.
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Puening SE, Wilson MP, Nordstrom K. Psychiatric Emergencies for Clinicians: Emergency Department Management of Benzodiazepine Withdrawal. J Emerg Med. 2017 01; 52(1):66-69.
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Raol YH, Lapides DA, Keating JG, Brooks-Kayal AR, Cooper EC. A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Ann Neurol. 2009 Mar; 65(3):326-36.
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Chilakapati J, Korrapati MC, Shankar K, Hill RA, Warbritton A, Latendresse JR, Mehendale HM. Role of CYP2E1 and saturation kinetics in the bioactivation of thioacetamide: Effects of diet restriction and phenobarbital. Toxicol Appl Pharmacol. 2007 Feb 15; 219(1):72-84.
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Dzhala VI, Talos DM, Sdrulla DA, Brumback AC, Mathews GC, Benke TA, Delpire E, Jensen FE, Staley KJ. NKCC1 transporter facilitates seizures in the developing brain. Nat Med. 2005 Nov; 11(11):1205-13.
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