 Retinal Pigment Epithelium
"Retinal Pigment Epithelium" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The single layer of pigment-containing epithelial cells in the RETINA, situated closely to the tips (outer segments) of the RETINAL PHOTORECEPTOR CELLS. These epithelial cells are macroglia that perform essential functions for the photoreceptor cells, such as in nutrient transport, phagocytosis of the shed photoreceptor membranes, and ensuring retinal attachment.
| Descriptor ID |
D055213
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| MeSH Number(s) |
A09.371.670.500 A09.371.729.887
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Retinal Pigment Epithelium".
Below are MeSH descriptors whose meaning is more specific than "Retinal Pigment Epithelium".
This graph shows the total number of publications written about "Retinal Pigment Epithelium" by people in this website by year, and whether "Retinal Pigment Epithelium" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 | | 2009 | 2 | 2 | 4 | | 2010 | 2 | 0 | 2 | | 2011 | 3 | 1 | 4 | | 2012 | 3 | 2 | 5 | | 2013 | 4 | 3 | 7 | | 2014 | 1 | 0 | 1 | | 2015 | 3 | 2 | 5 | | 2016 | 1 | 2 | 3 | | 2017 | 4 | 0 | 4 | | 2018 | 0 | 1 | 1 | | 2019 | 0 | 1 | 1 | | 2020 | 0 | 1 | 1 | | 2021 | 4 | 0 | 4 | | 2023 | 0 | 1 | 1 | | 2024 | 2 | 4 | 6 | | 2025 | 3 | 1 | 4 |
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Below are the most recent publications written about "Retinal Pigment Epithelium" by people in Profiles.
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Warwick AM, Yu L, Klingeborn M, Travis AM, Parmar VM, Bomze HM, Malek G, Gospe Iii SM. Reduced complex I activity in the retinal pigment epithelium, but not in rod photoreceptors, affects light signaling without impacting cell survival. J Biol Chem. 2025 Sep; 301(9):110586.
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Chatterjee S, Ghosh S, Sin Z, Babu VS, Preval LV, Davis E, Tran N, Bammidi S, Gautam P, Hose S, Sergeev Y, Flores-Bellver M, Ritter K, Jessen HJ, Al Diri I, Sinha D, Guha P. Age-Dependent Histone Deacetylase 3 Regulation by ßA3/A1-Crystallin and Inositol Hexaphosphate in Retinal Pigmented Epithelial Cells Reveals a Novel Pathway in Age-Related Macular Degeneration. Aging Cell. 2025 Sep; 24(9):e70163.
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Sreekumar PG, Nam MH, Hong E, Kannan R, Nagaraj RH. RAGE Is Essential for Subretinal Fibrosis in Laser-Induced Choroidal Neovascularization: Therapeutic Implications. Invest Ophthalmol Vis Sci. 2025 Jun 02; 66(6):30.
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Flores-Bellver M, Canto-Soler MV. Generation of Induced-Primary Retinal Pigment Epithelium from Human Retinal Organoids. Methods Mol Biol. 2025; 2848:197-214.
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Xiao JF, Luo W, Mani A, Barba H, Solanki A, Droho S, Lavine JA, Skondra D. Intravitreal Metformin Protects Against Choroidal Neovascularization and Light-Induced Retinal Degeneration. Int J Mol Sci. 2024 Oct 22; 25(21).
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Lisker-Cervantes A, Gill Z, Patnaik JL, Gnanaraj R, Lynch AM, Palestine AG, Mathias M, Manoharan N, Mandava N, de Carlo Forest TE. Association Between Systemic Levels of Vascular Endothelial Growth Factor and Optical Coherence Tomography Biomarkers in a Non-Neovascular Age-Related Macular Degeneration Cohort. Ophthalmic Surg Lasers Imaging Retina. 2025 Jan; 56(1):23-29.
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Sundararajan M, Rathinam SR, Thundikandy R, Kanakath A, Balamurugan S, Vedhanayaki R, Miller DC, Lim LL, Suhler EB, Al-Dhibi HA, Arellanes-Garcia L, Reddy AK, Feng S, Doan T, Porco TC, Shantha JG, Acharya NR, Gonzales JA. Association Between Baseline Macular Morphologic Features on Optical Coherence Tomography and Visual Outcomes in Patients with Vogt-Koyanagi-Harada Disease. Ocul Immunol Inflamm. 2025 Feb; 33(2):263-270.
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Ghosh S, Sharma R, Bammidi S, Koontz V, Nemani M, Yazdankhah M, Kedziora KM, Stolz DB, Wallace CT, Yu-Wei C, Franks J, Bose D, Shang P, Ambrosino HM, Dutton JR, Geng Z, Montford J, Ryu J, Rajasundaram D, Hose S, Sahel JA, Puertollano R, Finkel T, Zigler JS, Sergeev Y, Watkins SC, Goetzman ES, Ferrington DA, Flores-Bellver M, Kaarniranta K, Sodhi A, Bharti K, Handa JT, Sinha D. The AKT2/SIRT5/TFEB pathway as a potential therapeutic target in non-neovascular AMD. Nat Commun. 2024 Jul 21; 15(1):6150.
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de Carlo Forest TE, Gill Z, Lisker-Cervantes A, Gnanaraj R, Grove N, Patnaik JL, Lynch AM, Palestine AG, Mathias M, Manoharan N, Mandava N. Association Between Quantitative and Qualitative Imaging Biomarkers and Geographic Atrophy Growth Rate. Am J Ophthalmol. 2024 08; 264:168-177.
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K?nzel SH, Pohlmann D, Bonsen LZ, Krappitz M, Zeitz O, Joussen AM, Dubrac A, K?nzel SE. Transcriptome Analysis of Choroidal Endothelium Links Androgen Receptor Role to Central Serous Chorioretinopathy. Eur J Ophthalmol. 2024 Sep; 34(5):1532-1540.
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