 Lupus Coagulation Inhibitor
"Lupus Coagulation Inhibitor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antiphospholipid antibody found in association with systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC;), ANTIPHOSPHOLIPID SYNDROME; and in a variety of other diseases as well as in healthy individuals. In vitro, the antibody interferes with the conversion of prothrombin to thrombin and prolongs the partial thromboplastin time. In vivo, it exerts a procoagulant effect resulting in thrombosis mainly in the larger veins and arteries. It further causes obstetrical complications, including fetal death and spontaneous abortion, as well as a variety of hematologic and neurologic complications.
| Descriptor ID |
D016682
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| MeSH Number(s) |
D12.776.124.486.485.114.323.210.600 D12.776.124.790.651.114.323.210.600 D12.776.377.715.548.114.323.210.600 D23.113.475
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| Concept/Terms |
Lupus Coagulation Inhibitor- Lupus Coagulation Inhibitor
- Inhibitor, Lupus Coagulation
- Coagulation Inhibitor, Lupus
- Lupus Anticoagulant
- Anticoagulant, Lupus
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Below are MeSH descriptors whose meaning is more general than "Lupus Coagulation Inhibitor".
Below are MeSH descriptors whose meaning is more specific than "Lupus Coagulation Inhibitor".
This graph shows the total number of publications written about "Lupus Coagulation Inhibitor" by people in this website by year, and whether "Lupus Coagulation Inhibitor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 | | 1995 | 1 | 1 | 2 | | 1996 | 1 | 0 | 1 |
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Below are the most recent publications written about "Lupus Coagulation Inhibitor" by people in Profiles.
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Lyle CA, Gibson E, Lovejoy AE, Goldenberg NA. Acute prognostic factors for post-thrombotic syndrome in children with limb DVT: a bi-institutional cohort study. Thromb Res. 2013 Jan; 131(1):37-41.
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Metjian A, Lim W. ASH evidence-based guidelines: should asymptomatic patients with antiphospholipid antibodies receive primary prophylaxis to prevent thrombosis? Hematology Am Soc Hematol Educ Program. 2009; 247-9.
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Manco-Johnson MJ, Nuss R, Key N, Moertel C, Jacobson L, Meech S, Weinberg A, Lefkowitz J. Lupus anticoagulant and protein S deficiency in children with postvaricella purpura fulminans or thrombosis. J Pediatr. 1996 Mar; 128(3):319-23.
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Nuss R, Hays T, Manco-Johnson M. Childhood thrombosis. Pediatrics. 1995 Aug; 96(2 Pt 1):291-4.
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Manco-Johnson MJ, Nuss R. Lupus anticoagulant in children with thrombosis. Am J Hematol. 1995 Apr; 48(4):240-3.
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Hassell KL, Kressin DC, Neumann A, Ellison R, Marlar RA. Correlation of antiphospholipid antibodies and protein S deficiency with thrombosis in HIV-infected men. Blood Coagul Fibrinolysis. 1994 Aug; 5(4):455-62.
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Reece EA, Gabrielli S, Cullen MT, Zheng XZ, Hobbins JC, Harris EN. Recurrent adverse pregnancy outcome and antiphospholipid antibodies. Am J Obstet Gynecol. 1990 Jul; 163(1 Pt 1):162-9.
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Lockwood CJ, Romero R, Feinberg RF, Clyne LP, Coster B, Hobbins JC. The prevalence and biologic significance of lupus anticoagulant and anticardiolipin antibodies in a general obstetric population. Am J Obstet Gynecol. 1989 Aug; 161(2):369-73.
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Manoharan A, Gottlieb P. Bleeding in patients with lupus anticoagulant. Lancet. 1984 Jul 21; 2(8395):171.
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