 Phencyclidine
"Phencyclidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.
| Descriptor ID |
D010622
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| MeSH Number(s) |
D03.383.621.699
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| Concept/Terms |
Phencyclidine- Phencyclidine
- 1-(1-Phenylcyclohexyl)piperidine
- Angel Dust
- Dust, Angel
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Below are MeSH descriptors whose meaning is more general than "Phencyclidine".
Below are MeSH descriptors whose meaning is more specific than "Phencyclidine".
This graph shows the total number of publications written about "Phencyclidine" by people in this website by year, and whether "Phencyclidine" was a major or minor topic of these publications.
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Below are the most recent publications written about "Phencyclidine" by people in Profiles.
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Miller CL, Bickford PC, Luntz-Leybman V, Adler LE, Gerhardt GA, Freedman R. Phencyclidine and auditory sensory gating in the hippocampus of the rat. Neuropharmacology. 1992 Oct; 31(10):1041-8.
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Markwell MA, Berger SP, Paul SM. The polyamine synthesis inhibitor alpha-difluoromethylornithine blocks NMDA-induced neurotoxicity. Eur J Pharmacol. 1990 Jul 17; 182(3):607-9.
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Hoffman PL, Rabe CS, Moses F, Tabakoff B. N-methyl-D-aspartate receptors and ethanol: inhibition of calcium flux and cyclic GMP production. J Neurochem. 1989 Jun; 52(6):1937-40.
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Parfitt KD, Freedman R, Bickford-Wimer PC. Electrophysiological effects of locally applied noradrenergic agents at cerebellar Purkinje neurons: receptor specificity. Brain Res. 1988 Oct 18; 462(2):242-51.
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Gratton A, Hoffer BJ, Freedman R. Electrophysiological effects of phencyclidine in the medial prefrontal cortex of the rat. Neuropharmacology. 1987 Sep; 26(9):1275-83.
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Changeux JP, Pinset C, Ribera AB. Effects of chlorpromazine and phencyclidine on mouse C2 acetylcholine receptor kinetics. J Physiol. 1986 Sep; 378:497-513.
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