The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy.
Sadoshima J, Montagne O, Wang Q, Yang G, Warden J, Liu J, Takagi G, Karoor V, Hong C, Johnson GL, Vatner DE, Vatner SF. The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. J Clin Invest. 2002 Jul; 110(2):271-9.