TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.
Arbour NC, Lorenz E, Schutte BC, Zabner J, Kline JN, Jones M, Frees K, Watt JL, Schwartz DA. TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet. 2000 Jun; 25(2):187-91.