Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis.

Krishnan S, Chi EY, Wood SJ, Kendrick BS, Li C, Garzon-Rodriguez W, Wypych J, Randolph TW, Narhi LO, Biere AL, Citron M, Carpenter JF. Oxidative dimer formation is the critical rate-limiting step for Parkinson's disease alpha-synuclein fibrillogenesis. Biochemistry. 2003 Jan 28; 42(3):829-37.

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subject areas

alpha-Synuclein
Amino Acid Substitution
Chromatography, High Pressure Liquid
Cross-Linking Reagents
Dimerization
Humans
Hydrogen-Ion Concentration
Light
Nerve Tissue Proteins
Osmolar Concentration
Osmotic Pressure
Oxidation-Reduction
Oxidative Stress
Parkinson Disease
Protein Isoforms
Scattering, Radiation
Spectrometry, Mass, Electrospray Ionization
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Spectrophotometry, Ultraviolet
Synucleins
Temperature
Tyrosine

authors with profiles

Theodore W Randolph