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Dmitri Simberg

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-8241

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Griffin JI, Cheng SKK, Hayashi T, Carson D, Saraswathy M, Nair DP, Simberg D. Cell-penetrating peptide CGKRK mediates efficient and widespread targeting of bladder mucosa following focal injury. Nanomedicine. 2017 Apr 17. PMID: 28428051.
      View in: PubMed
    2. Wang G, Griffin JI, Inturi S, Brenneman B, Banda NK, Holers VM, Moghimi SM, Simberg D. In Vitro and In Vivo Differences in Murine Third Complement Component (C3) Opsonization and Macrophage/Leukocyte Responses to Antibody-Functionalized Iron Oxide Nanoworms. Front Immunol. 2017; 8:151. PMID: 28239384.
      View in: PubMed
    3. Anchordoquy TJ, Barenholz Y, Boraschi D, Chorny M, Decuzzi P, Dobrovolskaia MA, Farhangrazi ZS, Farrell D, Gabizon A, Ghandehari H, Godin B, La-Beck NM, Ljubimova J, Moghimi SM, Pagliaro L, Park JH, Peer D, Ruoslahti E, Serkova NJ, Simberg D. Mechanisms and Barriers in Cancer Nanomedicine: Addressing Challenges, Looking for Solutions. ACS Nano. 2017 Jan 24; 11(1):12-18. PMID: 28068099.
      View in: PubMed
    4. Griffin JI, Benchimol MJ, Simberg D. Longitudinal monitoring of skin accumulation of nanocarriers and biologicals with fiber optic near infrared fluorescence spectroscopy (FONIRS). J Control Release. 2017 Feb 10; 247:167-174. PMID: 28069552.
      View in: PubMed
    5. Chen F, Wang G, Griffin JI, Brenneman B, Banda NK, Holers VM, Backos DS, Wu L, Moghimi SM, Simberg D. Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo. Nat Nanotechnol. 2017 May; 12(4):387-393. PMID: 27992410.
      View in: PubMed
    6. Wang G, Chen F, Banda NK, Holers VM, Wu L, Moghimi SM, Simberg D. Activation of Human Complement System by Dextran-Coated Iron Oxide Nanoparticles Is Not Affected by Dextran/Fe Ratio, Hydroxyl Modifications, and Crosslinking. Front Immunol. 2016; 7:418. PMID: 27777575.
      View in: PubMed
    7. Simberg D. Iron oxide nanoparticles and the mechanisms of immune recognition of nanomedicines. Nanomedicine (Lond). 2016 Apr; 11(7):741-3. PMID: 26979409.
      View in: PubMed
    8. Inturi S, Wang G, Chen F, Banda NK, Holers VM, Wu L, Moghimi SM, Simberg D. Modulatory Role of Surface Coating of Superparamagnetic Iron Oxide Nanoworms in Complement Opsonization and Leukocyte Uptake. ACS Nano. 2015 Nov 24; 9(11):10758-68. PMID: 26488074.
      View in: PubMed
    9. Simberg D. Opening Windows into Tumors. ACS Nano. 2015 Sep 22; 9(9):8647-50. PMID: 26340308.
      View in: PubMed
    10. Banda NK, Mehta G, Chao Y, Wang G, Inturi S, Fossati-Jimack L, Botto M, Wu L, Moghimi SM, Simberg D. Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum. Part Fibre Toxicol. 2014 Nov 26; 11:64. PMID: 25425420; PMCID: PMC4247556.
    11. Wang G, Inturi S, Serkova NJ, Merkulov S, McCrae K, Russek SE, Banda NK, Simberg D. High-relaxivity superparamagnetic iron oxide nanoworms with decreased immune recognition and long-circulating properties. ACS Nano. 2014 Dec 23; 8(12):12437-49. PMID: 25419856; PMCID: PMC4692719.
    12. Ibsen S, Shi G, Schutt C, Shi L, Suico KD, Benchimol M, Serra V, Simberg D, Berns M, Esener S. The behavior of lipid debris left on cell surfaces from microbubble based ultrasound molecular imaging. Ultrasonics. 2014 Dec; 54(8):2090-8. PMID: 25059435; PMCID: PMC4151124.
    13. Mukthavaram R, Shi G, Kesari S, Simberg D. Targeting and depletion of circulating leukocytes and cancer cells by lipophilic antibody-modified erythrocytes. J Control Release. 2014 Jun 10; 183:146-53. PMID: 24685706.
      View in: PubMed
    14. Ortac I, Simberg D, Yeh YS, Yang J, Messmer B, Trogler WC, Tsien RY, Esener S. Dual-porosity hollow nanoparticles for the immunoprotection and delivery of nonhuman enzymes. Nano Lett. 2014 Jun 11; 14(6):3023-32. PMID: 24471767; PMCID: PMC4059531.
    15. Mukthavaram R, Jiang P, Saklecha R, Simberg D, Bharati IS, Nomura N, Chao Y, Pastorino S, Pingle SC, Fogal V, Wrasidlo W, Makale M, Kesari S. High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile. Int J Nanomedicine. 2013; 8:3991-4006. PMID: 24174874; PMCID: PMC3808212.
    16. Shi G, Cui W, Mukthavaram R, Liu YT, Simberg D. Binding and isolation of tumor cells in biological media with perfluorocarbon microbubbles. Methods. 2013 Dec 01; 64(2):102-7. PMID: 23974072; PMCID: PMC3841068.
    17. Shi G, Mukthavaram R, Kesari S, Simberg D. Distearoyl anchor-painted erythrocytes with prolonged ligand retention and circulation properties in vivo. Adv Healthc Mater. 2014 Jan; 3(1):142-8. PMID: 23798381; PMCID: PMC3956753.
    18. Chao Y, Karmali PP, Mukthavaram R, Kesari S, Kouznetsova VL, Tsigelny IF, Simberg D. Direct recognition of superparamagnetic nanocrystals by macrophage scavenger receptor SR-AI. ACS Nano. 2013 May 28; 7(5):4289-98. PMID: 23614696.
      View in: PubMed
    19. Shi G, Cui W, Benchimol M, Liu YT, Mattrey RF, Mukthavaram R, Kesari S, Esener SC, Simberg D. Isolation of rare tumor cells from blood cells with buoyant immuno-microbubbles. PLoS One. 2013; 8(3):e58017. PMID: 23516425; PMCID: PMC3596333.
    20. Chao Y, Makale M, Karmali PP, Sharikov Y, Tsigelny I, Merkulov S, Kesari S, Wrasidlo W, Ruoslahti E, Simberg D. Recognition of dextran-superparamagnetic iron oxide nanoparticle conjugates (Feridex) via macrophage scavenger receptor charged domains. Bioconjug Chem. 2012 May 16; 23(5):1003-9. PMID: 22515422; PMCID: PMC3444675.
    21. Karmali PP, Chao Y, Park JH, Sailor MJ, Ruoslahti E, Esener SC, Simberg D. Different effect of hydrogelation on antifouling and circulation properties of dextran-iron oxide nanoparticles. Mol Pharm. 2012 Mar 05; 9(3):539-45. PMID: 22243419; PMCID: PMC3295900.
    22. Chao Y, Karmali PP, Simberg D. Role of carbohydrate receptors in the macrophage uptake of dextran-coated iron oxide nanoparticles. Adv Exp Med Biol. 2012; 733:115-23. PMID: 22101717.
      View in: PubMed
    23. Ibsen S, Benchimol M, Simberg D, Esener S. Ultrasound mediated localized drug delivery. Adv Exp Med Biol. 2012; 733:145-53. PMID: 22101720.
      View in: PubMed
    24. Ibsen S, Benchimol M, Simberg D, Schutt C, Steiner J, Esener S. A novel nested liposome drug delivery vehicle capable of ultrasound triggered release of its payload. J Control Release. 2011 Nov 07; 155(3):358-66. PMID: 21745505; PMCID: PMC3196035.
    25. Karmali PP, Simberg D. Interactions of nanoparticles with plasma proteins: implication on clearance and toxicity of drug delivery systems. Expert Opin Drug Deliv. 2011 Mar; 8(3):343-57. PMID: 21291354.
      View in: PubMed
    26. Simberg D, Zhang WM, Merkulov S, McCrae K, Park JH, Sailor MJ, Ruoslahti E. Contact activation of kallikrein-kinin system by superparamagnetic iron oxide nanoparticles in vitro and in vivo. J Control Release. 2009 Dec 16; 140(3):301-5. PMID: 19508879; PMCID: PMC2787880.
    27. Simberg D, Mattrey R. Targeting of perfluorocarbon microbubbles to selective populations of circulating blood cells. J Drug Target. 2009 Jun; 17(5):392-8. PMID: 19505207.
      View in: PubMed
    28. Simberg D, Park JH, Karmali PP, Zhang WM, Merkulov S, McCrae K, Bhatia SN, Sailor M, Ruoslahti E. Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance. Biomaterials. 2009 Aug; 30(23-24):3926-33. PMID: 19394687; PMCID: PMC2792080.
    29. Park JH, von Maltzahn G, Zhang L, Derfus AM, Simberg D, Harris TJ, Ruoslahti E, Bhatia SN, Sailor MJ. Systematic surface engineering of magnetic nanoworms for in vivo tumor targeting. Small. 2009 Mar; 5(6):694-700. PMID: 19263431; PMCID: PMC3058937.
    30. Simberg D, Duza T, Park JH, Essler M, Pilch J, Zhang L, Derfus AM, Yang M, Hoffman RM, Bhatia S, Sailor MJ, Ruoslahti E. Biomimetic amplification of nanoparticle homing to tumors. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):932-6. PMID: 17215365; PMCID: PMC1783417.
    31. Khazanov E, Simberg D, Barenholz Y. Lipoplexes prepared from cationic liposomes and mammalian DNA induce CpG-independent, direct cytotoxic effects in cell cultures and in mice. J Gene Med. 2006 Aug; 8(8):998-1007. PMID: 16741997.
      View in: PubMed
    32. Joseph A, Itskovitz-Cooper N, Samira S, Flasterstein O, Eliyahu H, Simberg D, Goldwaser I, Barenholz Y, Kedar E. A new intranasal influenza vaccine based on a novel polycationic lipid--ceramide carbamoyl-spermine (CCS) I. Immunogenicity and efficacy studies in mice. Vaccine. 2006 May 01; 24(18):3990-4006. PMID: 16516356.
      View in: PubMed
    33. Simberg D, Weiss A, Barenholz Y. Reversible mode of binding of serum proteins to DOTAP/cholesterol Lipoplexes: a possible explanation for intravenous lipofection efficiency. Hum Gene Ther. 2005 Sep; 16(9):1087-96. PMID: 16149907.
      View in: PubMed
    34. Simberg D, Weisman S, Talmon Y, Barenholz Y. DOTAP (and other cationic lipids): chemistry, biophysics, and transfection. Crit Rev Ther Drug Carrier Syst. 2004; 21(4):257-317. PMID: 15638468.
      View in: PubMed
    35. Simberg D, Weisman S, Talmon Y, Faerman A, Shoshani T, Barenholz Y. The role of organ vascularization and lipoplex-serum initial contact in intravenous murine lipofection. J Biol Chem. 2003 Oct 10; 278(41):39858-65. PMID: 12869564.
      View in: PubMed
    36. Simberg D, Danino D, Talmon Y, Minsky A, Ferrari ME, Wheeler CJ, Barenholz Y. Phase behavior, DNA ordering, and size instability of cationic lipoplexes. Relevance to optimal transfection activity. J Biol Chem. 2001 Dec 14; 276(50):47453-9. PMID: 11564736.
      View in: PubMed
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