Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Rebecca LeAnne McCullough

TitleAssistant Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-DOPS General Operations
Phone303/724-6415

    Collapse Research 
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    K99AA025386     (SMATHERS MCCULLOUGH, REBECCA LEANNE)Feb 15, 2017 - Jan 31, 2019
    NIH
    Altered Treg differentiation in ALD: a novel role for anaphylatoxins C3a and C5a
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Anton PE, Twardy S, Nagpal P, Moreno JA, Burchill MA, Chatterjee A, Busquet N, Mesches M, Kovacs EJ, McCullough RL. Suppression of NF-?B/NLRP3 by nanoligomer therapy mitigates ethanol and advanced age-related neuroinflammation. J Leukoc Biol. 2025 Apr 23; 117(4). PMID: 40036603.
      View in: PubMed
    2. Tschann MM, Vachharajani V, Redmond EM, Hoisington A, Cohen SE, New-Aaron M, Llorente C, Paloczi J, Keating CR, Rungratanawanich W, Burnham EL, Callaci JJ, Raju P, Zhong W, Mandal A, Zimmerly JR, Nuncio ASP, Mandrekar P, McCullough RL, McMahan RH, Wyatt TA, Yeligar SM, Kovacs EJ, Choudhry MA. New developments on the effects of alcohol use on immunity, inflammation and organ function: A summary of the 2024 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2025 Apr 21; 126:1-10. PMID: 40267994.
      View in: PubMed
    3. Saikia P, Roychowdhury S, Bellos D, Pollard KA, McMullen MR, McCullough RL, McCullough AJ, Gholam P, de la Motte C, Nagy LE. Author Correction: Hyaluronic acid 35 normalizes TLR4 signaling in Kupffer cells from ethanol-fed rats via regulation of microRNA291b and its target Tollip. Sci Rep. 2025 Mar 21; 15(1):9766. PMID: 40118974.
      View in: PubMed
    4. Kremer KN, Khammash HA, Miranda AM, Rutt LN, Twardy SM, Anton PE, Campbell ML, Garza-Ortiz C, Orlicky DJ, Pelanda R, McCullough RL, Torres RM. Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance. Front Immunol. 2024; 15:1497788. PMID: 39896805.
      View in: PubMed
    5. Rutt LN, Orlicky DJ, McCullough RL. Investigating the role of Wnt3a and Wnt5a as critical factors of hepatic stellate cell activation in acute toxicant-induced liver injury. Cell Biol Toxicol. 2024 12 21; 41(1):5. PMID: 39707064.
      View in: PubMed
    6. Anton PE, Rutt LN, Kaufman ML, Busquet N, Kovacs EJ, McCullough RL. Corrigendum to "Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice" [Brain Behav. Immun. 116 (2024) 303-316]. Brain Behav Immun. 2024 Aug; 120:644-645. PMID: 38702200.
      View in: PubMed
    7. Rutt LN, Liu M, Melamed E, Twardy S, Sturgill JL, Brenner LA, Hardesty J, Weinman SA, Tschann MM, Travers J, Welsh DA, Chichetto N, Crotty KM, Mackowiak B, Yeligar SM, Wyatt TA, McMahan RH, Choudry MA, Kovacs EJ, McCullough RL. Emerging concepts in alcohol, infection & immunity: A summary of the 2023 alcohol and immunology research interest group (AIRIG) meeting. Alcohol. 2024 08; 118:9-16. PMID: 38582261.
      View in: PubMed
    8. Anton PE, Nagpal P, Moreno J, Burchill MA, Chatterjee A, Busquet N, Mesches M, Kovacs EJ, McCullough RL. NF-?B/NLRP3 Translational Inhibition by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation. bioRxiv. 2024 Feb 28. PMID: 38464118.
      View in: PubMed
    9. Trujillo MN, Jennings EQ, Hoffman EA, Zhang H, Phoebe AM, Mastin GE, Kitamura N, Reisz JA, Megill E, Kantner D, Marcinkiewicz MM, Twardy SM, Lebario F, Chapman E, McCullough RL, D'Alessandro A, Snyder NW, Cusanovich DA, Galligan JJ. Lactoylglutathione promotes inflammatory signaling in macrophages through histone lactoylation. Mol Metab. 2024 Mar; 81:101888. PMID: 38307385.
      View in: PubMed
    10. Anton PE, Rutt LN, Kaufman ML, Busquet N, Kovacs EJ, McCullough RL. Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice. Brain Behav Immun. 2024 02; 116:303-316. PMID: 38151165.
      View in: PubMed
    11. Trujillo MN, Jennings EQ, Hoffman EA, Zhang H, Phoebe AM, Mastin GE, Kitamura N, Reisz JA, Megill E, Kantner D, Marcinkiewicz MM, Twardy SM, Lebario F, Chapman E, McCullough RL, D'Alessandro A, Snyder NW, Cusanovich DA, Galligan JJ. Lactoylglutathione promotes inflammatory signaling in macrophages. bioRxiv. 2023 Oct 10. PMID: 37873172.
      View in: PubMed
    12. McMahan RH, Anton P, Coleman LG, Cresci GAM, Crews FT, Crotty KM, Luck ME, Molina PE, Vachharajani V, Weinberg J, Yeligar SM, Choudhry MA, McCullough RL, Kovacs EJ. Alcohol and Immunology: Mechanisms of multi-organ damage. Summary of the 2022 alcohol and Immunology research interest group (AIRIG) meeting. Alcohol. 2023 08; 110:57-63. PMID: 37061143.
      View in: PubMed
    13. Moghimi SM, McCullough R, Simberg D. Revisiting nanoparticle transendothelial migration in the liver. Mol Ther. 2023 03 01; 31(3):605-606. PMID: 36754053.
      View in: PubMed
    14. Hvizdak M, Kandel SE, Work HM, Gracey EG, McCullough RL, Lampe JN. Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement. J Inorg Biochem. 2023 03; 240:112120. PMID: 36638633.
      View in: PubMed
    15. Anton P, Rutt LN, Twardy SM, McCullough RL. Fatty Acid Ethyl Ethers: New Modulators of Acute Ethanol-Mediated Hepatotoxicity? Cell Mol Gastroenterol Hepatol. 2023; 15(2):505-506. PMID: 36435276.
      View in: PubMed
    16. Goldberg AR, Ferguson M, Pal S, Cohen R, Orlicky DJ, McCullough RL, Rutkowski JM, Burchill MA, Tamburini BAJ. Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin. Front Physiol. 2022; 13:1021038. PMID: 36338478.
      View in: PubMed
    17. Anton PE, Rutt LN, Capper C, Orlicky DJ, McCullough RL. Profiling the oxylipidome in aged mice after chronic ethanol feeding: Identifying lipid metabolites as drivers of hepatocyte stress. Alcohol. 2023 03; 107:119-135. PMID: 36150611.
      View in: PubMed
    18. Khair S, Brenner LA, Koval M, Samuelson D, Cucinello-Regland JA, Anton P, Piano MR, Simon L, Crotty K, Sharieh F, Travers JB, Singh V, Cannon A, Kim A, McCullough RL, Yeligar SM, Wyatt TA, McMahan RH, Choudhry MA, Kovacs EJ. New insights into the mechanism of alcohol-mediated organ damage via its impact on immunity, metabolism, and repair pathways: A summary of the 2021 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2022 09; 103:1-7. PMID: 35659577.
      View in: PubMed
    19. Harris PS, Michel CR, Yun Y, McGinnis CD, Assiri MA, Ahmadi AR, Sun Z, Roede JR, Burchill MA, Orlicky DJ, McCullough RL, Fritz KS. Proteomic analysis of alcohol-associated hepatitis reveals glycoprotein NMB (GPNMB) as a novel hepatic and serum biomarker. Alcohol. 2022 03; 99:35-48. PMID: 34923085.
      View in: PubMed
    20. Davuluri G, Welch N, Sekar J, Gangadhariah M, Alsabbagh Alchirazi K, Mohan ML, Kumar A, Kant S, Thapaliya S, Stine M, McMullen MR, McCullough RL, Stark GR, Nagy LE, Naga Prasad SV, Dasarathy S. Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease. Hepatology. 2021 05; 73(5):1892-1908. PMID: 32799332.
      View in: PubMed
    21. Fan X, McCullough RL, Huang E, Bellar A, Kim A, Poulsen KL, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Rotroff DM, Nagy LE. Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis. Hepatology. 2021 03; 73(3):983-997. PMID: 32557728.
      View in: PubMed
    22. Walrath T, Dyamenahalli KU, Hulsebus HJ, McCullough RL, Idrovo JP, Boe DM, McMahan RH, Kovacs EJ. Age-related changes in intestinal immunity and the microbiome. J Leukoc Biol. 2021 06; 109(6):1045-1061. PMID: 33020981.
      View in: PubMed
    23. Burchill MA, Finlon JM, Goldberg AR, Gillen AE, Dahms PA, McMahan RH, Tye A, Winter AB, Reisz JA, Bohrnsen E, Schafer JB, D'Alessandro A, Orlicky DJ, Kriss MS, Rosen HR, McCullough RL, Jir?n Tamburini BA. Oxidized Low-Density Lipoprotein Drives Dysfunction of the Liver Lymphatic System. Cell Mol Gastroenterol Hepatol. 2021; 11(2):573-595. PMID: 32961356.
      View in: PubMed
    24. McMahan RH, Afshar M, Amedee AM, Bishehsari F, Carr RM, Coleman LG, Herrnreiter CJ, Lewis SL, Mandrekar P, McCullough RL, Morris NL, Vasiliou V, Wang HJ, Yeligar SM, Choudhry MA, Kovacs EJ. Summary of the 2019 alcohol and immunology research interest group (AIRIG) meeting: Alcohol-mediated mechanisms of multiple organ injury. Alcohol. 2020 09; 87:89-95. PMID: 32353591.
      View in: PubMed
    25. McCullough RL, McMullen MR, Poulsen KL, Kim A, Medof ME, Nagy LE. Anaphylatoxin Receptors C3aR and C5aR1 Are Important Factors That Influence the Impact of Ethanol on the Adipose Secretome. Front Immunol. 2018; 9:2133. PMID: 30294325.
      View in: PubMed
    26. McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE. Complement Factor D protects mice from ethanol-induced inflammation and liver injury. Am J Physiol Gastrointest Liver Physiol. 2018 07 01; 315(1):G66-G79. PMID: 29597356.
      View in: PubMed
    27. Kim A, McCullough RL, Poulsen KL, Sanz-Garcia C, Sheehan M, Stavitsky AB, Nagy LE. Hepatic Immune System: Adaptations to Alcohol. Handb Exp Pharmacol. 2018; 248:347-367. PMID: 29374837.
      View in: PubMed
    28. Saikia P, Roychowdhury S, Bellos D, Pollard KA, McMullen MR, McCullough RL, McCullough AJ, Gholam P, de la Motte C, Nagy LE. Hyaluronic acid 35 normalizes TLR4 signaling in Kupffer cells from ethanol-fed rats via regulation of microRNA291b and its target Tollip. Sci Rep. 2017 Nov 15; 7(1):15671. PMID: 29142263.
      View in: PubMed
    29. Roychowdhury S, McCullough RL, Sanz-Garcia C, Saikia P, Alkhouri N, Matloob A, Pollard KA, McMullen MR, Croniger CM, Nagy LE. Receptor interacting protein 3 protects mice from high-fat diet-induced liver?injury. Hepatology. 2016 11; 64(5):1518-1533. PMID: 27301788.
      View in: PubMed
    30. McCullough RL, Saikia P, Pollard KA, McMullen MR, Nagy LE, Roychowdhury S. Myeloid Mixed Lineage Kinase 3 Contributes to Chronic Ethanol-Induced Inflammation and Hepatocyte Injury in Mice. Gene Expr. 2016; 17(1):61-77. PMID: 27302422.
      View in: PubMed
    31. McCullough RL, McMullen MR, Das D, Roychowdhury S, Strainic MG, Medof ME, Nagy LE. Differential contribution of complement receptor C5aR in myeloid and non-myeloid cells in chronic ethanol-induced liver injury in mice. Mol Immunol. 2016 07; 75:122-32. PMID: 27280845.
      View in: PubMed
    32. Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles BL, Saba LM, Ronis MJ, Petersen DR. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS One. 2016; 11(4):e0154152. PMID: 27124661.
      View in: PubMed
    33. Smathers RL, Chiang DJ, McMullen MR, Feldstein AE, Roychowdhury S, Nagy LE. Soluble IgM links apoptosis to complement activation in early alcoholic liver disease in mice. Mol Immunol. 2016 Apr; 72:9-18. PMID: 26922040.
      View in: PubMed
    34. Galligan JJ, Fritz KS, Backos DS, Shearn CT, Smathers RL, Jiang H, MacLean KN, Reigan PR, Petersen DR. Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function. Free Radic Biol Med. 2014 Aug; 73:411-20. PMID: 24924946.
      View in: PubMed
    35. Shearn CT, Mercer KE, Orlicky DJ, Hennings L, Smathers-McCullough RL, Stiles BL, Ronis MJ, Petersen DR. Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice. PLoS One. 2014; 9(5):e96553. PMID: 24818992.
      View in: PubMed
    36. Shearn CT, Backos DS, Orlicky DJ, Smathers-McCullough RL, Petersen DR. Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol. J Biol Chem. 2014 May 30; 289(22):15449-62. PMID: 24722988.
      View in: PubMed
    37. Shearn CT, Smathers RL, Backos DS, Reigan P, Orlicky DJ, Petersen DR. Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis. Free Radic Biol Med. 2013 Dec; 65:680-692. PMID: 23872024.
      View in: PubMed
    38. Shearn CT, Smathers RL, Jiang H, Orlicky DJ, Maclean KN, Petersen DR. Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis. J Nutr Biochem. 2013 Aug; 24(8):1436-45. PMID: 23465594.
      View in: PubMed
    39. Smathers RL, Galligan JJ, Shearn CT, Fritz KS, Mercer K, Ronis M, Orlicky DJ, Davidson NO, Petersen DR. Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver. J Lipid Res. 2013 May; 54(5):1335-45. PMID: 23359610.
      View in: PubMed
    40. Galligan JJ, Smathers RL, Shearn CT, Fritz KS, Backos DS, Jiang H, Franklin CC, Orlicky DJ, Maclean KN, Petersen DR. Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease. J Toxicol. 2012; 2012:207594. PMID: 22829816.
      View in: PubMed
    41. Smathers RL, Fritz KS, Galligan JJ, Shearn CT, Reigan P, Marks MJ, Petersen DR. Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. PLoS One. 2012; 7(6):e38459. PMID: 22701647.
      View in: PubMed
    42. Galligan JJ, Smathers RL, Fritz KS, Epperson LE, Hunter LE, Petersen DR. Protein carbonylation in a murine model for early alcoholic liver disease. Chem Res Toxicol. 2012 May 21; 25(5):1012-21. PMID: 22502949.
      View in: PubMed
    43. Fritz KS, Galligan JJ, Smathers RL, Roede JR, Shearn CT, Reigan P, Petersen DR. 4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification. Chem Res Toxicol. 2011 May 16; 24(5):651-62. PMID: 21449565.
      View in: PubMed
    44. Shearn CT, Smathers RL, Stewart BJ, Fritz KS, Galligan JJ, Hail N, Petersen DR. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibition by 4-hydroxynonenal leads to increased Akt activation in hepatocytes. Mol Pharmacol. 2011 Jun; 79(6):941-52. PMID: 21415306.
      View in: PubMed
    45. Galligan JJ, Fritz KS, Tipney H, Smathers RL, Roede JR, Shearn CT, Hunter LE, Petersen DR. Profiling impaired hepatic endoplasmic reticulum glycosylation as a consequence of ethanol ingestion. J Proteome Res. 2011 Apr 01; 10(4):1837-47. PMID: 21319786.
      View in: PubMed
    46. Smathers RL, Petersen DR. The human fatty acid-binding protein family: evolutionary divergences and functions. Hum Genomics. 2011 Mar; 5(3):170-91. PMID: 21504868.
      View in: PubMed
    47. Smathers RL, Galligan JJ, Stewart BJ, Petersen DR. Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease. Chem Biol Interact. 2011 Jun 30; 192(1-2):107-12. PMID: 21354120.
      View in: PubMed
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