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Timothy P Garrington

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone720/777-8365

    Collapse Research 
    Collapse research activities and funding
    K08CA085276     (GARRINGTON, TIMOTHY P)Apr 1, 2000 - Mar 31, 2006
    NIH/NCI
    MEKK2 KO DEFINES HEMATOPOIETIC CELL SIGNAL FUNCTION
    Role: Principal Investigator

    R25CA160013     (OVERHOLSER, LINDA)Sep 25, 2012 - Aug 31, 2017
    NIH/NCI
    Promoting Healthy Cancer Survivorship in Rural Colorado Primary Health Care Pract
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Deeney S, Stewart C, Treece AL, Black JO, Lovell MA, Garrington T, Karrer F, Bruny J. Diagnostic utility of core needle biopsy versus open wedge biopsy for pediatric intraabdominal solid tumors: Results of a prospective clinical study. J Pediatr Surg. 2017 Sep 04. PMID: 28943139.
      View in: PubMed
    2. Carrasco A, Caldwell BT, Cost CR, Greffe BS, Garrington TP, Bruny JL, Black JO, Cost NG. Reliability of intraoperative frozen section for the diagnosis of renal tumors suspicious for malignancy in children and adolescents. Pediatr Blood Cancer. 2017 Aug; 64(8). PMID: 28097784.
      View in: PubMed
    3. Stokes W, Amini A, Maroni PD, Kessler ER, Stokes C, Cost CR, Greffe BS, Garrington TP, Liu AK, Cost NG. Patterns of care and survival outcomes for adolescent and young adult patients with testicular seminoma in the United States: A National Cancer Database analysis. J Pediatr Urol. 2017 Aug; 13(4):386.e1-386.e7. PMID: 28153774.
      View in: PubMed
    4. Amini A, Waxweiler TV, Maroni PD, Kessler ER, Cost CR, Greffe BS, Garrington TP, Liu AK, Cost NG. Survival outcomes of adolescent and adult patients with non-seminomatous testicular germ-cell tumors: A population-based study. J Pediatr Urol. 2016 Dec; 12(6):405.e1-405.e9. PMID: 27544905.
      View in: PubMed
    5. Amini A, Murphy B, Cost CR, Garrington TP, Greffe BS, Liu AK. Cardiac Mortality in Children and Adolescents with Hodgkin's Lymphoma: A Surveillance, Epidemiology and End Results Analysis. J Adolesc Young Adult Oncol. 2016 Jun; 5(2):181-6. PMID: 26959398.
      View in: PubMed
    6. Overholser LS, Moss KM, Kilbourn K, Risendal B, Jones AF, Greffe BS, Garrington T, Leonardi-Warren K, Yamashita TE, Kutner JS. Development of a Primary Care-Based Clinic to Support Adults With a History of Childhood Cancer: The Tactic Clinic. J Pediatr Nurs. 2015 Sep-Oct; 30(5):724-31. PMID: 26278341.
      View in: PubMed
    7. Waxweiler TV, Rusthoven CG, Proper MS, Cost CR, Cost NG, Donaldson N, Garrington T, Greffe BS, Heare T, Macy ME, Liu AK. Non-Rhabdomyosarcoma Soft Tissue Sarcomas in Children: A Surveillance, Epidemiology, and End Results Analysis Validating COG Risk Stratifications. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):339-48. PMID: 25968827.
      View in: PubMed
    8. Acker SN, Linton J, Tan GM, Garrington TP, Bruny J, Hilden JM, Hoffman LM, Partrick DA. A multidisciplinary approach to the management of anterior mediastinal masses in children. J Pediatr Surg. 2015 May; 50(5):875-8. PMID: 25783332.
      View in: PubMed
    9. Acker SN, Bruny JL, Garrington TP, Partrick DA. Minimally invasive surgical techniques are safe in the diagnosis and treatment of pediatric malignancies. Surg Endosc. 2015 May; 29(5):1203-8. PMID: 25159642.
      View in: PubMed
    10. Simko SJ, Tran HD, Jones J, Bilgi M, Beaupin LK, Coulter D, Garrington T, McCavit TL, Moore C, Rivera-Ortegón F, Shaffer L, Stork L, Turcotte L, Welsh EC, Hicks MJ, McClain KL, Allen CE. Clofarabine salvage therapy in refractory multifocal histiocytic disorders, including Langerhans cell histiocytosis, juvenile xanthogranuloma and Rosai-Dorfman disease. Pediatr Blood Cancer. 2014 Mar; 61(3):479-87. PMID: 24106153; PMCID: PMC4474604.
    11. Brown RD, Ambler SK, Li M, Sullivan TM, Henry LN, Crossno JT, Long CS, Garrington TP, Stenmark KR. MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2013 Jan 15; 304(2):H269-81. PMID: 23125215; PMCID: PMC3543664.
    12. May LT, Wang M, Albano E, Garrington T, Dishop M, Macy ME. Undifferentiated sarcoma of the liver: a single institution experience using a uniform treatment approach. J Pediatr Hematol Oncol. 2012 Apr; 34(3):e114-6. PMID: 22217489; PMCID: PMC4131680.
    13. Grunzke M, Hayes K, Bourland W, Garrington T. Diffuse cavitary lung lesions. Pediatr Radiol. 2010 Feb; 40(2):215-8. PMID: 19779928.
      View in: PubMed
    14. Macy ME, Sawczyn KK, Garrington TP, Graham DK, Gore L. Pediatric developmental therapies: interesting new drugs now in early-stage clinical trials. Curr Oncol Rep. 2008 Nov; 10(6):477-90. PMID: 18928662; PMCID: PMC3309527.
    15. Alsultan A, Lovell MA, Hayes KL, Allshouse MJ, Garrington TP. Simultaneous occurrence of right adrenocortical tumor and left adrenal neuroblastoma in an infant with Beckwith-Wiedemann syndrome. Pediatr Blood Cancer. 2008 Nov; 51(5):695-8. PMID: 18668518.
      View in: PubMed
    16. Liang X, Greffe B, Garrington T, Graham DK. Precursor natural killer cell leukemia. Pediatr Blood Cancer. 2008 Apr; 50(4):876-8. PMID: 17417789.
      View in: PubMed
    17. Deterding RR, Wong S, Faries G, Glover JJ, Garrington TP, Wang M, Anderson MS, Krugman RD. The new University of Colorado medical school curriculum: a pediatric perspective. J Pediatr. 2007 Nov; 151(5 Suppl):S32-6. PMID: 17950321.
      View in: PubMed
    18. Sawczyn KK, Quinones R, Malcolm J, Foreman N, Garrington T, Gore L, Gao D, Giller R. Cord blood transplant in childhood ALL. Pediatr Blood Cancer. 2005 Dec; 45(7):964-70. PMID: 15929135.
      View in: PubMed
    19. Cuevas BD, Uhlik MT, Garrington TP, Johnson GL. MEKK1 regulates the AP-1 dimer repertoire via control of JunB transcription and Fra-2 protein stability. Oncogene. 2005 Jan 27; 24(5):801-9. PMID: 15558021.
      View in: PubMed
    20. Kesavan K, Lobel-Rice K, Sun W, Lapadat R, Webb S, Johnson GL, Garrington TP. MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts. J Cell Physiol. 2004 Apr; 199(1):140-8. PMID: 14978743.
      View in: PubMed
    21. Wei X, Sun W, Fan R, Hahn J, Joetham A, Li G, Webb S, Garrington T, Dakhama A, Lucas J, Johnson GL, Gelfand EW. MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells. Eur J Immunol. 2003 Oct; 33(10):2903-9. PMID: 14515274.
      View in: PubMed
    22. Sun W, Wei X, Kesavan K, Garrington TP, Fan R, Mei J, Anderson SM, Gelfand EW, Johnson GL. MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src. Mol Cell Biol. 2003 Apr; 23(7):2298-308. PMID: 12640115; PMCID: PMC150715.
    23. Bild AH, Mendoza FJ, Gibson EM, Huang M, Villanueva J, Garrington TP, Jove R, Johnson GL, Gibson SB. MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage. Oncogene. 2002 Sep 26; 21(43):6649-56. PMID: 12242663.
      View in: PubMed
    24. Chayama K, Papst PJ, Garrington TP, Pratt JC, Ishizuka T, Webb S, Ganiatsas S, Zon LI, Sun W, Johnson GL, Gelfand EW. Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4599-604. PMID: 11274363; PMCID: PMC31880.
    25. Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL. MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway. J Biol Chem. 2001 Feb 16; 276(7):5093-100. PMID: 11073940.
      View in: PubMed
    26. Garrington TP, Ishizuka T, Papst PJ, Chayama K, Webb S, Yujiri T, Sun W, Sather S, Russell DM, Gibson SB, Keller G, Gelfand EW, Johnson GL. MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells. EMBO J. 2000 Oct 16; 19(20):5387-95. PMID: 11032806; PMCID: PMC314024.
    27. Clarke P, Meintzer SM, Gibson S, Widmann C, Garrington TP, Johnson GL, Tyler KL. Reovirus-induced apoptosis is mediated by TRAIL. J Virol. 2000 Sep; 74(17):8135-9. PMID: 10933724; PMCID: PMC112347.
    28. Yujiri T, Fanger GR, Garrington TP, Schlesinger TK, Gibson S, Johnson GL. MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton. J Biol Chem. 1999 Apr 30; 274(18):12605-10. PMID: 10212239.
      View in: PubMed
    29. Garrington TP, Johnson GL. Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr Opin Cell Biol. 1999 Apr; 11(2):211-8. PMID: 10209154.
      View in: PubMed
    30. Garrington T, Silliman CC, Bensard D, Ingram JD. Response to successful management of a child with asparaginase- induced hemorrhagic pancreatitis. Med Pediatr Oncol. 1998 Aug; 31(2):127. PMID: 9714616.
      View in: PubMed
    31. Garrington T, Bensard D, Ingram JD, Silliman CC. Successful management with octreotide of a child with L-asparaginase induced hemorrhagic pancreatitis. Med Pediatr Oncol. 1998 Feb; 30(2):106-9. PMID: 9403019.
      View in: PubMed
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