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Masanori Hayashi

TitleAssistant Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Biography 
    Collapse education and training
    Keio University, Tokyo, JapanMD03/2005Medicine
    Duke University Medical Center, Durham, NC06/2010Pediatrics
    National Cancer Institute, Bethesda, MD06/2014Pediatric Hematology/Oncology
    Johns Hopkins University , Baltimore, MD06/2014Pediatric Hematolog/Oncology
    Johns Hopkins University, Baltimore, MD06/2016Sarcoma Biology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Goodspeed A, Bodlak A, Duffy AB, Nelson-Taylor S, Oike N, Porfilio T, Shirai R, Walker D, Treece A, Black J, Donaldson N, Cost C, Garrington T, Greffe B, Luna-Fineman S, Demedis J, Lake J, Danis E, Verneris MR, Adams DL, Hayashi M. Single-Cell RNA Sequencing of Ewing Sarcoma Tumors Demonstrates Transcriptional Heterogeneity and Clonal Evolution. Clin Cancer Res. 2025 May 15; 31(10):2010-2023. PMID: 40029262.
      View in: PubMed
    2. Kastner L, Kandalaft W, Mahant Mahant A, Crimella J, Hakim S, Peng X, Isakoff MS, Hayashi M, Loeb DM. Cytokine Profiling of Children, Adolescents, and Young Adults Newly Diagnosed with Sarcomas Demonstrates a Role for IL-1? in Osteosarcoma Metastasis. medRxiv. 2025 Apr 07. PMID: 40297413.
      View in: PubMed
    3. Kuo C, Giannikou K, Wang N, Warren M, Goodspeed A, Shillingford N, Hayashi M, Raredon MSB, Amatruda JF. Tumor-associated stroma shapes the spatial tumor immune microenvironment of primary Ewing sarcomas. bioRxiv. 2025 Feb 06. PMID: 39975230.
      View in: PubMed
    4. Dhir A, Hayashi M, Bodlak A, Oesterheld J, Loeb DM, Mascarenhas L, Isakoff MS, Sandler ES, Borinstein SC, Trucco M, Lagmay JP, Setty BA, Pratilas CA, Caywood E, Metts J, Yin H, Fridley B, Yin J, Laborde J, Reed DR, Adams DL, Wagner LM. Phase II Trial of Gemcitabine and Nab-Paclitaxel for Recurrent Osteosarcoma with Serial Monitoring Using Liquid Biopsy: A Report from the National Pediatric Cancer Foundation. Clin Cancer Res. 2024 Dec 02; 30(23):5314-5322. PMID: 39360936.
      View in: PubMed
    5. Lake JA, Woods E, Hoffmeyer E, Schaller KL, Cruz-Cruz J, Fernandez J, Tufa D, Kooiman B, Hall SC, Jones D, Hayashi M, Verneris MR. Directing B7-H3 chimeric antigen receptor T cell homing through IL-8 induces potent antitumor activity against pediatric sarcoma. J Immunother Cancer. 2024 Jul 23; 12(7). PMID: 39043604.
      View in: PubMed
    6. Goodspeed A, Bodlak A, Duffy AB, Nelson-Taylor S, Oike N, Porfilio T, Shirai R, Walker D, Treece A, Black J, Donaldson N, Cost C, Garrington T, Greffe B, Luna-Fineman S, Demedis J, Lake J, Danis E, Verneris M, Adams DL, Hayashi M. Characterization of transcriptional heterogeneity and novel therapeutic targets using single cell RNA-sequencing of primary and circulating Ewing sarcoma cells. bioRxiv. 2024 Jun 20. PMID: 38293103.
      View in: PubMed
    7. Offenbacher R, Jackson KW, Hayashi M, Zhang J, Peng D, Tan Y, Stewart TM, Ciero P, Foley J, Casero RA, Cahan P, Loeb DM. Polyamine Depletion by D, L-alpha-difluoromethylornithine Inhibits Ewing Sarcoma Metastasis by Inducing Ferroptosis. bioRxiv. 2024 Jun 17. PMID: 38948823.
      View in: PubMed
    8. Shirai R, Biebighauser T, Walker D, Oviedo J, Nelson-Taylor S, Bodlak A, Porfilio T, Oike N, Goodspeed A, Hayashi M. Cadherin-11 contributes to the heterogenous and dynamic Wnt-Wnt-?-catenin pathway activation in Ewing sarcoma. PLoS One. 2024; 19(6):e0305490. PMID: 38875295.
      View in: PubMed
    9. Hayashi M, Obara H, Matsuda S, Homma K, Sasaki J, Matsubara K, Higuchi M, Sano M, Masugi Y, Kitagawa Y. Protective Effects of Hydrogen Gas Inhalation for Hindlimb Ischaemia-Reperfusion Injury in a Mouse Model. Eur J Vasc Endovasc Surg. 2024 Jul; 68(1):120-128. PMID: 38301869.
      View in: PubMed
    10. Moody KM, Andersen C, Bradley J, Draper L, Garrington T, Gill J, Harrison D, Hayashi M, Heaton A, Holladay C, Lion A, Rajan A, Rozo B, Runco D, Salvador L, Ferguson V, Arnold R. In-person and virtual adaptation of an interprofessional palliative care communications skills training course for pediatric oncology clinicians. Res Sq. 2023 Aug 11. PMID: 37609163.
      View in: PubMed
    11. Weiser DA, Hayashi M, Applebaum MA. Breaking Up Isn't Hard to Do: Isolating Cell-free DNA Fragments in Osteosarcoma. Clin Cancer Res. 2023 06 01; 29(11):2017-2019. PMID: 36976253.
      View in: PubMed
    12. Ligon JA, Hayashi M, Ciampa D, Kramer C, Guastella A, Fuchs RJ, Herati AS, Christianson MS, Chen AR. A multidisciplinary pediatric oncofertility team improves fertility preservation and counseling across 7?years. Cancer Rep (Hoboken). 2023 02; 6(2):e1753. PMID: 36346013.
      View in: PubMed
    13. Shulman DS, Whittle SB, Surdez D, Bailey KM, de ?lava E, Yustein JT, Shlien A, Hayashi M, Bishop AJR, Crompton BD, DuBois SG, Shukla N, Leavey PJ, Lessnick SL, Kovar H, Delattre O, Gr?newald TGP, Antonescu CR, Roberts RD, Toretsky JA, Tirode F, Gorlick R, Janeway KA, Reed D, Lawlor ER, Grohar PJ. An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma. NPJ Precis Oncol. 2022 Sep 17; 6(1):65. PMID: 36115869.
      View in: PubMed
    14. Oike N, Kawashima H, Ogose A, Hatano H, Ariizumi T, Yamagishi T, Murayama Y, Umezu H, Imai C, Hayashi M, Endo N. Human leukocyte antigen I is significantly downregulated in patients with myxoid liposarcomas. Cancer Immunol Immunother. 2021 Dec; 70(12):3489-3499. PMID: 33893830.
      View in: PubMed
    15. Bodlak A, Chang K, Channel J, Treece AL, Donaldson N, Cost CR, Garrington TP, Greffe B, Luna-Fineman S, Sopfe J, Loeb DM, Hayashi M. Circulating Plasma Tumor DNA Is Superior to Plasma Tumor RNA Detection in Ewing Sarcoma Patients: ptDNA and ptRNA in Ewing Sarcoma. J Mol Diagn. 2021 07; 23(7):872-881. PMID: 33887462.
      View in: PubMed
    16. Koo J, Hayashi M, Verneris MR, Lee-Sherick AB. Targeting Tumor-Associated Macrophages in the Pediatric Sarcoma Tumor Microenvironment. Front Oncol. 2020; 10:581107. PMID: 33381449.
      View in: PubMed
    17. Nellan A, Bodlak A, Mirsky DM, Mulcahy Levy J, Garrington TP, Foreman NK, Gilani A, Hayashi M. ddPCR Analysis Reveals BRAF V600E Mutations Are Infrequent in Isolated Pituitary Langerhans Cell Histiocytosis Patients. J Neuropathol Exp Neurol. 2020 12 04; 79(12):1313-1319. PMID: 32930721.
      View in: PubMed
    18. Brechbuhl HM, Vinod-Paul K, Gillen AE, Kopin EG, Gibney K, Elias AD, Hayashi M, Sartorius CA, Kabos P. Analysis of circulating breast cancer cell heterogeneity and interactions with peripheral blood mononuclear cells. Mol Carcinog. 2020 10; 59(10):1129-1139. PMID: 32822091.
      View in: PubMed
    19. Oesterheld JE, Reed DR, Setty BA, Isakoff MS, Thompson P, Yin H, Hayashi M, Loeb DM, Smith T, Makanji R, Fridley BL, Wagner LM. Phase II trial of gemcitabine and nab-paclitaxel in patients with recurrent Ewing sarcoma: A report from the National Pediatric Cancer Foundation. Pediatr Blood Cancer. 2020 07; 67(7):e28370. PMID: 32386107.
      View in: PubMed
    20. Reed DR, Metts J, Pressley M, Fridley BL, Hayashi M, Isakoff MS, Loeb DM, Makanji R, Roberts RD, Trucco M, Wagner LM, Alexandrow MG, Gatenby RA, Brown JS. An evolutionary framework for treating pediatric sarcomas. Cancer. 2020 06 01; 126(11):2577-2587. PMID: 32176331.
      View in: PubMed
    21. Borinstein SC, Steppan D, Hayashi M, Loeb DM, Isakoff MS, Binitie O, Brohl AS, Bridge JA, Stavas M, Shinohara ET, Meyer WH, Reed DR, Wagner LM. Consensus and controversies regarding the treatment of rhabdomyosarcoma. Pediatr Blood Cancer. 2018 Feb; 65(2). PMID: 28905489.
      View in: PubMed
    22. Hayashi M, Zhu P, McCarty G, Meyer CF, Pratilas CA, Levin A, Morris CD, Albert CM, Jackson KW, Tang CM, Loeb DM. Size-based detection of sarcoma circulating tumor cells and cell clusters. Oncotarget. 2017 Oct 03; 8(45):78965-78977. PMID: 29108279.
      View in: PubMed
    23. Llosa NJ, Cooke KR, Chen AR, Gamper CJ, Klein OR, Zambidis ET, Luber B, Rosner G, Siegel N, Holuba MJ, Robey N, Hayashi M, Jones RJ, Fuchs E, Holdhoff M, Loeb DM, Symons HJ. Reduced-Intensity Haploidentical Bone Marrow Transplantation with Post-Transplant Cyclophosphamide for Solid Tumors in Pediatric and Young Adult Patients. Biol Blood Marrow Transplant. 2017 Dec; 23(12):2127-2136. PMID: 28807769.
      View in: PubMed
    24. Hayashi M, Baker A, Goldstein SD, Albert CM, Jackson KW, McCarty G, Kahlert UD, Loeb DM. Inhibition of porcupine prolongs metastasis free survival in a mouse xenograft model of Ewing sarcoma. Oncotarget. 2017 Oct 03; 8(45):78265-78276. PMID: 29108227.
      View in: PubMed
    25. Reed DR, Hayashi M, Wagner L, Binitie O, Steppan DA, Brohl AS, Shinohara ET, Bridge JA, Loeb DM, Borinstein SC, Isakoff MS. Treatment pathway of bone sarcoma in children, adolescents, and young adults. Cancer. 2017 Jun 15; 123(12):2206-2218. PMID: 28323337.
      View in: PubMed
    26. Hayashi M, Chu D, Meyer CF, Llosa NJ, McCarty G, Morris CD, Levin AS, Wolinsky JP, Albert CM, Steppan DA, Park BH, Loeb DM. Highly personalized detection of minimal Ewing sarcoma disease burden from plasma tumor DNA. Cancer. 2016 10; 122(19):3015-23. PMID: 27351911.
      View in: PubMed
    27. Goldstein SD, Trucco M, Bautista Guzman W, Hayashi M, Loeb DM. A monoclonal antibody against the Wnt signaling inhibitor dickkopf-1 inhibits osteosarcoma metastasis in a preclinical model. Oncotarget. 2016 Apr 19; 7(16):21114-23. PMID: 27049730.
      View in: PubMed
    28. Kahlert UD, Suwala AK, Koch K, Natsumeda M, Orr BA, Hayashi M, Maciaczyk J, Eberhart CG. Pharmacologic Wnt Inhibition Reduces Proliferation, Survival, and Clonogenicity of Glioblastoma Cells. J Neuropathol Exp Neurol. 2015 Sep; 74(9):889-900. PMID: 26222502.
      View in: PubMed
    29. Goldstein SD, Hayashi M, Albert CM, Jackson KW, Loeb DM. An orthotopic xenograft model with survival hindlimb amputation allows investigation of the effect of tumor microenvironment on sarcoma metastasis. Clin Exp Metastasis. 2015 Oct; 32(7):703-15. PMID: 26278104.
      View in: PubMed
    30. Hayashi M, Strouse JJ, Veltri MA, Curtis BR, Takemoto CM. Immune thrombocytopenia due to Trimethoprim-Sulfamethoxazole; under-recognized adverse drug reaction in children? Pediatr Blood Cancer. 2015 May; 62(5):922-3. PMID: 25683320.
      View in: PubMed
    31. Resetkova N, Hayashi M, Kolp LA, Christianson MS. Fertility Preservation for Prepubertal Girls: Update and Current Challenges. Curr Obstet Gynecol Rep. 2013 Dec 01; 2(4):218-225. PMID: 25110617.
      View in: PubMed
    32. Hayashi M, Calatroni A, Herzberg B, Ross AK, Rice HE, Thornburg C. Impact of hydroxyurea on perioperative management and outcomes in children with sickle cell anemia. J Pediatr Hematol Oncol. 2011 Oct; 33(7):487-90. PMID: 21941139.
      View in: PubMed
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