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Michael Graner

TitleProfessor-Research
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-NS General Operations
Phone303/724-4133

    Collapse Research 
    Collapse research activities and funding
    R33MH118174     (GRANER, MICHAEL W)Sep 18, 2018 - Aug 31, 2023
    NIH
    Development of Validation of Phage-Displayed Random Peptide Libraries Technologies for Rapid Isolation and Characterization of Extracellular Vesicles from Patients with Brain Tumors
    Role: Principal Investigator
    R21MH118174     (GRANER, MICHAEL W)Sep 18, 2018 - Aug 31, 2020
    NIH
    Development of Validation of Phage-Displayed Random Peptide Libraries Technologies for Rapid Isolation and Characterization of Extracellular Vesicles from Patients with Brain Tumors
    Role: Principal Investigator
    R01GM129046     (ANCHORDOQUY, THOMAS)Aug 1, 2018 - Apr 30, 2022
    NIH
    Exploiting an endogenous transcytotic pathway for oral drug delivery
    Role: Co-Principal Investigator
    R01EB016378     (ANCHORDOQUY, THOMAS)Aug 1, 2013 - Jul 31, 2018
    NIH
    Tumor-Homing Exosomes for Drug Delivery
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhou W, Craft J, Ojemann A, Bergen L, Graner A, Gonzales A, He Q, Kopper T, Smith M, Graner MW, Yu X. Glioblastoma Extracellular Vesicle-Specific Peptides Inhibit EV-Induced Neuronal Cytotoxicity. Int J Mol Sci. 2022 Jun 28; 23(13). PMID: 35806205.
      View in: PubMed
    2. Tatman PD, Wroblewski TH, Fringuello AR, Scherer SR, Foreman WB, Damek DM, Lillehei KO, Jensen RL, Youssef AS, Ormond DR, Graner MW. Targeting DNA Methyl Transferases with Decitabine in Cultured Meningiomas. World Neurosurg. 2022 06; 162:e99-e119. PMID: 35248772.
      View in: PubMed
    3. Uphaus T, Audebert HJ, Graner MW, Tiedt S, Kowalski RG. Editorial: Blood-Based Biomarkers in Acute Ischemic Stroke and Hemorrhagic Stroke. Front Neurol. 2022; 13:866166. PMID: 35280278.
      View in: PubMed
    4. Kennedy PGE, Graner MW, Fringuello A, Zhou W, Pointon T, Alquatli K, Bisel S, Langford D, Yu X. Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, Distinguish Multiple Sclerosis From Other Neurological Disorders. J Neuroimmune Pharmacol. 2022 Jan 06. PMID: 34989971.
      View in: PubMed
    5. Fringuello A, Tatman PD, Wroblewski T, Thompson JA, Yu X, Lillehei KO, Kowalski RG, Graner MW. Cytokine-Laden Extracellular Vesicles Predict Patient Prognosis after Cerebrovascular Accident. Int J Mol Sci. 2021 Jul 22; 22(15). PMID: 34360613.
      View in: PubMed
    6. Tatman PD, Wroblewski TH, Fringuello AR, Scherer SR, Foreman WB, Damek DM, Lillehei K, Youssef AS, Jensen RL, Graner MW, Ormond DR. High-Throughput Mechanistic Screening of Epigenetic Compounds for the Potential Treatment of Meningiomas. J Clin Med. 2021 Jul 16; 10(14). PMID: 34300316.
      View in: PubMed
    7. Kennedy PGE, Graner M, Pointon T, Li X, Tanimoto K, Dennison K, Im G, Fringuello A, Zhou W, Graner A, Sillau S, Vollmer T, Yu X. Aberrant Immunoglobulin G Glycosylation in Multiple Sclerosis. J Neuroimmune Pharmacol. 2021 May 03. PMID: 33942224.
      View in: PubMed
    8. Graner MW. Making HSP90 Inhibitors Great Again? Unite for Better Cancer Immunotherapy. Cell Chem Biol. 2021 02 18; 28(2):118-120. PMID: 33607004.
      View in: PubMed
    9. Yu X, Graner M, Kennedy PGE, Liu Y. The Role of Antibodies in the Pathogenesis of Multiple Sclerosis. Front Neurol. 2020; 11:533388. PMID: 33192968.
      View in: PubMed
    10. Coughlan C, Bruce KD, Burgy O, Boyd TD, Michel CR, Garcia-Perez JE, Adame V, Anton P, Bettcher BM, Chial HJ, Königshoff M, Hsieh EWY, Graner M, Potter H. Exosome Isolation by Ultracentrifugation and Precipitation and Techniques for Downstream Analyses. Curr Protoc Cell Biol. 2020 09; 88(1):e110. PMID: 32633898.
      View in: PubMed
    11. Wang Z, Kennedy PG, Dupree C, Wang M, Lee C, Pointon T, Langford TD, Graner MW, Yu X. Antibodies from Multiple Sclerosis Brain Identified Epstein-Barr Virus Nuclear Antigen 1 & 2 Epitopes which Are Recognized by Oligoclonal Bands. J Neuroimmune Pharmacol. 2021 09; 16(3):567-580. PMID: 32808238.
      View in: PubMed
    12. Kennedy PGE, Graner MW, Walker D, Pointon T, Fringuello A, Yu X. Recombinant antibodies derived from laser captured single plasma cells of multiple sclerosis brain identified phage peptides which may be used as tools for characterizing intrathecal IgG response. J Neuroimmunol. 2020 10 15; 347:577319. PMID: 32717427.
      View in: PubMed
    13. Kennedy PG, Graner MW, Gunaydin D, Bowlin J, Pointon T, Yu X. Varicella-Zoster Virus infected human neurons are resistant to apoptosis. J Neurovirol. 2020 06; 26(3):330-337. PMID: 32125664.
      View in: PubMed
    14. Graner M, Pointon T, Manton S, Green M, Dennison K, Davis M, Braiotta G, Craft J, Edwards T, Polonsky B, Fringuello A, Vollmer T, Yu X. Oligoclonal IgG antibodies in multiple sclerosis target patient-specific peptides. PLoS One. 2020; 15(2):e0228883. PMID: 32084151.
      View in: PubMed
    15. Graner MW. Roles of Extracellular Vesicles in High-Grade Gliomas: Tiny Particles with Outsized Influence. Annu Rev Genomics Hum Genet. 2019 08 31; 20:331-357. PMID: 30978305.
      View in: PubMed
    16. Graner M. V-ATPase expression in gliomas-Not your grandparents' proton pump. EBioMedicine. 2019 Mar; 41:13-14. PMID: 30808578.
      View in: PubMed
    17. Betker JL, Angle BM, Graner MW, Anchordoquy TJ. The Potential of Exosomes From Cow Milk for Oral Delivery. J Pharm Sci. 2019 04; 108(4):1496-1505. PMID: 30468828.
      View in: PubMed
    18. Graner MW. Extracellular vesicles in cancer immune responses: roles of purinergic receptors. Semin Immunopathol. 2018 09; 40(5):465-475. PMID: 30209547.
      View in: PubMed
    19. Graner MW, Schnell S, Olin MR. Tumor-derived exosomes, microRNAs, and cancer immune suppression. Semin Immunopathol. 2018 09; 40(5):505-515. PMID: 29869058.
      View in: PubMed
    20. Oushy S, Hellwinkel JE, Wang M, Nguyen GJ, Gunaydin D, Harland TA, Anchordoquy TJ, Graner MW. Glioblastoma multiforme-derived extracellular vesicles drive normal astrocytes towards a tumour-enhancing phenotype. Philos Trans R Soc Lond B Biol Sci. 2018 Jan 05; 373(1737). PMID: 29158308.
      View in: PubMed
    21. Contreras-Zárate MJ, Ormond DR, Gillen AE, Hanna C, Day NL, Serkova NJ, Jacobsen BM, Edgerton SM, Thor AD, Borges VF, Lillehei KO, Graner MW, Kabos P, Cittelly DM. Development of Novel Patient-Derived Xenografts from Breast Cancer Brain Metastases. Front Oncol. 2017; 7:252. PMID: 29164052.
      View in: PubMed
    22. Beseler C, Vollmer T, Graner M, Yu X. The complex relationship between oligoclonal bands, lymphocytes in the cerebrospinal fluid, and immunoglobulin G antibodies in multiple sclerosis: Indication of serum contribution. PLoS One. 2017; 12(10):e0186842. PMID: 29059249.
      View in: PubMed
    23. Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931657.
      View in: PubMed
    24. Zhou K, Spillman MA, Behbakht K, Komatsu JM, Abrahante JE, Hicks D, Schotl B, Odean E, Jones KL, Graner MW, Bemis LT. A method for extracting and characterizing RNA from urine: For downstream PCR and RNAseq analysis. Anal Biochem. 2017 11 01; 536:8-15. PMID: 28803886.
      View in: PubMed
    25. Graner AN, Hellwinkel JE, Lencioni AM, Madsen HJ, Harland TA, Marchando P, Nguyen GJ, Wang M, Russell LM, Bemis LT, Anchordoquy TJ, Graner MW. HSP90 inhibitors in the context of heat shock and the unfolded protein response: effects on a primary canine pulmonary adenocarcinoma cell line. Int J Hyperthermia. 2017 May; 33(3):303-317. PMID: 27829290.
      View in: PubMed
    26. Redzic JS, Gomez JD, Hellwinkel JE, Anchordoquy TJ, Graner MW. Proteomic analyses of brain tumor cell lines amidst the unfolded protein response. Oncotarget. 2016 Jul 26; 7(30):47831-47847. PMID: 27323862.
      View in: PubMed
    27. Kunigelis KE, Graner MW. The Dichotomy of Tumor Exosomes (TEX) in Cancer Immunity: Is It All in the ConTEXt? Vaccines (Basel). 2015 Dec 17; 3(4):1019-51. PMID: 26694473.
      View in: PubMed
    28. Graner MW. HSP90 and Immune Modulation in Cancer. Adv Cancer Res. 2016; 129:191-224. PMID: 26916006.
      View in: PubMed
    29. Hellwinkel JE, Redzic JS, Harland TA, Gunaydin D, Anchordoquy TJ, Graner MW. Glioma-derived extracellular vesicles selectively suppress immune responses. Neuro Oncol. 2016 Apr; 18(4):497-506. PMID: 26385614.
      View in: PubMed
    30. Schlaepfer IR, Nambiar DK, Ramteke A, Kumar R, Dhar D, Agarwal C, Bergman B, Graner M, Maroni P, Singh RP, Agarwal R, Deep G. Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation. Oncotarget. 2015 Sep 08; 6(26):22836-56. PMID: 26087400.
      View in: PubMed
    31. Graner MW. The unfolded protein response in glioblastomas: targetable or trouble? Future Sci OA. 2015 Sep; 1(2):FSO45. PMID: 28031873.
      View in: PubMed
    32. Yáñez-Mó M, Siljander PR, Andreu Z, Zavec AB, Borràs FE, Buzas EI, Buzas K, Casal E, Cappello F, Carvalho J, Colás E, Cordeiro-da Silva A, Fais S, Falcon-Perez JM, Ghobrial IM, Giebel B, Gimona M, Graner M, Gursel I, Gursel M, Heegaard NH, Hendrix A, Kierulf P, Kokubun K, Kosanovic M, Kralj-Iglic V, Krämer-Albers EM, Laitinen S, Lässer C, Lener T, Ligeti E, Line A, Lipps G, Llorente A, Lötvall J, Mancek-Keber M, Marcilla A, Mittelbrunn M, Nazarenko I, Nolte-'t Hoen EN, Nyman TA, O'Driscoll L, Olivan M, Oliveira C, Pállinger É, Del Portillo HA, Reventós J, Rigau M, Rohde E, Sammar M, Sánchez-Madrid F, Santarém N, Schallmoser K, Ostenfeld MS, Stoorvogel W, Stukelj R, Van der Grein SG, Vasconcelos MH, Wauben MH, De Wever O. Biological properties of extracellular vesicles and their physiological functions. J Extracell Vesicles. 2015; 4:27066. PMID: 25979354.
      View in: PubMed
    33. Yu Y, Jin D, Hu S, Zhang Y, Zheng X, Zheng J, Liao M, Chen X, Graner M, Liu H, Jin Q. A novel tuberculosis antigen identified from human tuberculosis granulomas. Mol Cell Proteomics. 2015 Apr; 14(4):1093-103. PMID: 25605460.
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    34. Graner MW, Lillehei KO, Katsanis E. Endoplasmic reticulum chaperones and their roles in the immunogenicity of cancer vaccines. Front Oncol. 2014; 4:379. PMID: 25610811.
      View in: PubMed
    35. Smyth T, Kullberg M, Malik N, Smith-Jones P, Graner MW, Anchordoquy TJ. Biodistribution and delivery efficiency of unmodified tumor-derived exosomes. J Control Release. 2015 Feb 10; 199:145-55. PMID: 25523519.
      View in: PubMed
    36. Ung TH, Madsen HJ, Hellwinkel JE, Lencioni AM, Graner MW. Exosome proteomics reveals transcriptional regulator proteins with potential to mediate downstream pathways. Cancer Sci. 2014 Nov; 105(11):1384-92. PMID: 25220623.
      View in: PubMed
    37. Smyth T, Petrova K, Payton NM, Persaud I, Redzic JS, Graner MW, Smith-Jones P, Anchordoquy TJ. Surface functionalization of exosomes using click chemistry. Bioconjug Chem. 2014 Oct 15; 25(10):1777-84. PMID: 25220352.
      View in: PubMed
    38. Smyth TJ, Redzic JS, Graner MW, Anchordoquy TJ. Examination of the specificity of tumor cell derived exosomes with tumor cells in vitro. Biochim Biophys Acta. 2014 Nov; 1838(11):2954-65. PMID: 25102470.
      View in: PubMed
    39. Redzic JS, Ung TH, Graner MW. Glioblastoma extracellular vesicles: reservoirs of potential biomarkers. Pharmgenomics Pers Med. 2014; 7:65-77. PMID: 24634586.
      View in: PubMed
    40. Liao M, Yang Q, Zhang J, Zhang M, Deng Q, Liu H, Graner MW, Kornfeld H, Zhou B, Chen X. Gamma interferon immunospot assay of pleural effusion mononuclear cells for diagnosis of tuberculous pleurisy. Clin Vaccine Immunol. 2014 Mar; 21(3):347-53. PMID: 24391138.
      View in: PubMed
    41. Ramteke A, Ting H, Agarwal C, Mateen S, Somasagara R, Hussain A, Graner M, Frederick B, Agarwal R, Deep G. Exosomes secreted under hypoxia enhance invasiveness and stemness of prostate cancer cells by targeting adherens junction molecules. Mol Carcinog. 2015 Jul; 54(7):554-65. PMID: 24347249.
      View in: PubMed
    42. Graner MW. The unfolded protein response in glioblastomas: passing the stress test. CNS Oncol. 2013 Nov; 2(6):469-72. PMID: 25054814.
      View in: PubMed
    43. Epple LM, Dodd RD, Merz AL, Dechkovskaia AM, Herring M, Winston BA, Lencioni AM, Russell RL, Madsen H, Nega M, Dusto NL, White J, Bigner DD, Nicchitta CV, Serkova NJ, Graner MW. Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells. PLoS One. 2013; 8(8):e73267. PMID: 24039668.
      View in: PubMed
    44. Redzic JS, Kendrick AA, Bahmed K, Dahl KD, Pearson CG, Robinson WA, Robinson SE, Graner MW, Eisenmesser EZ. Extracellular vesicles secreted from cancer cell lines stimulate secretion of MMP-9, IL-6, TGF-ß1 and EMMPRIN. PLoS One. 2013; 8(8):e71225. PMID: 23936495.
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    45. Epple LM, Bemis LT, Cavanaugh RP, Skope A, Mayer-Sonnenfeld T, Frank C, Olver CS, Lencioni AM, Dusto NL, Tal A, Har-Noy M, Lillehei KO, Katsanis E, Graner MW. Prolonged remission of advanced bronchoalveolar adenocarcinoma in a dog treated with autologous, tumour-derived chaperone-rich cell lysate (CRCL) vaccine. Int J Hyperthermia. 2013 Aug; 29(5):390-8. PMID: 23786302.
      View in: PubMed
    46. Mayer-Sonnenfeld T, Har-Noy M, Lillehei KO, Graner MW. Proteomic analyses of different human tumour-derived chaperone-rich cell lysate (CRCL) anti-cancer vaccines reveal antigen content and strong similarities amongst the vaccines along with a basis for CRCL's unique structure: CRCL vaccine proteome leads to unique structure. Int J Hyperthermia. 2013 Sep; 29(6):520-7. PMID: 23734882.
      View in: PubMed
    47. Graner MW, Romanoski A, Katsanis E. The 'peptidome' of tumour-derived chaperone-rich cell lysate anti-cancer vaccines reveals potential tumour antigens that stimulate tumour immunity. Int J Hyperthermia. 2013 Aug; 29(5):380-9. PMID: 23725202.
      View in: PubMed
    48. Epple LM, Griffiths SG, Dechkovskaia AM, Dusto NL, White J, Ouellette RJ, Anchordoquy TJ, Bemis LT, Graner MW. Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles. PLoS One. 2012; 7(7):e42064. PMID: 22848702.
      View in: PubMed
    49. Zhang M, Zheng X, Zhang J, Zhu Y, Zhu X, Liu H, Zeng M, Graner MW, Zhou B, Chen X. CD19(+)CD1d(+)CD5(+) B cell frequencies are increased in patients with tuberculosis and suppress Th17 responses. Cell Immunol. 2012; 274(1-2):89-97. PMID: 22361174.
      View in: PubMed
    50. Qiu Z, Zhang M, Zhu Y, Zheng F, Lu P, Liu H, Graner MW, Zhou B, Chen X. Multifunctional CD4 T cell responses in patients with active tuberculosis. Sci Rep. 2012; 2:216. PMID: 22355730.
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    51. Marshall D, Mitchell DA, Graner MW, Bigner DD. Immunotherapy of brain tumors. Handb Clin Neurol. 2012; 104:309-30. PMID: 22230450.
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    52. Zhang M, Wang Z, Graner MW, Yang L, Liao M, Yang Q, Gou J, Zhu Y, Wu C, Liu H, Zhou B, Chen X. B cell infiltration is associated with the increased IL-17 and IL-22 expression in the lungs of patients with tuberculosis. Cell Immunol. 2011; 270(2):217-23. PMID: 21741035.
      View in: PubMed
    53. Zhang M, Wang H, Liao M, Chen X, Graner M, Zhu X, Zhang J, Yang Q, Lu H, Zhou B, Chen X. Diagnosis of latent tuberculosis infection in bacille Calmette-Guérin vaccinated subjects in China by interferon-gamma ELISpot assay. Int J Tuberc Lung Dis. 2010 Dec; 14(12):1556-63. PMID: 21144240.
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    54. Chen X, Zhang M, Liao M, Graner MW, Wu C, Yang Q, Liu H, Zhou B. Reduced Th17 response in patients with tuberculosis correlates with IL-6R expression on CD4+ T Cells. Am J Respir Crit Care Med. 2010 Apr 01; 181(7):734-42. PMID: 20019339.
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    55. Chen X, Zhang M, Zhu X, Deng Q, Liu H, Larmonier N, Graner MW, Zhou B. Engagement of Toll-like receptor 2 on CD4(+) T cells facilitates local immune responses in patients with tuberculous pleurisy. J Infect Dis. 2009 Aug 01; 200(3):399-408. PMID: 19552525.
      View in: PubMed
    56. Graner MW, Raynes DA, Bigner DD, Guerriero V. Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces. Cancer Sci. 2009 Oct; 100(10):1870-9. PMID: 19659607.
      View in: PubMed
    57. Chen X, Yang Q, Zhang M, Graner M, Zhu X, Larmonier N, Liao M, Yu W, Deng Q, Zhou B. Diagnosis of active tuberculosis in China using an in-house gamma interferon enzyme-linked immunospot assay. Clin Vaccine Immunol. 2009 Jun; 16(6):879-84. PMID: 19339489.
      View in: PubMed
    58. Graner MW, Alzate O, Dechkovskaia AM, Keene JD, Sampson JH, Mitchell DA, Bigner DD. Proteomic and immunologic analyses of brain tumor exosomes. FASEB J. 2009 May; 23(5):1541-57. PMID: 19109410.
      View in: PubMed
    59. Bleifuss E, Bendz H, Sirch B, Thompson S, Brandl A, Milani V, Graner MW, Drexler I, Kuppner M, Katsanis E, Noessner E, Issels RD. Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens. Int J Hyperthermia. 2008 Dec; 24(8):623-37. PMID: 18608582.
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    60. Vega EA, Graner MW, Sampson JH. Combating immunosuppression in glioma. Future Oncol. 2008 Jun; 4(3):433-42. PMID: 18518768.
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    61. Everson RG, Graner MW, Gromeier M, Vredenburgh JJ, Desjardins A, Reardon DA, Friedman HS, Friedman AH, Bigner DD, Sampson JH. Immunotherapy against angiogenesis-associated targets: evidence and implications for the treatment of malignant glioma. Expert Rev Anticancer Ther. 2008 May; 8(5):717-32. PMID: 18471045.
      View in: PubMed
    62. Graner MW, Cumming RI, Bigner DD. The heat shock response and chaperones/heat shock proteins in brain tumors: surface expression, release, and possible immune consequences. J Neurosci. 2007 Oct 17; 27(42):11214-27. PMID: 17942716.
      View in: PubMed
    63. Li G, Zeng Y, Chen X, Larmonier N, Sepassi M, Graner MW, Andreansky S, Brewer MA, Katsanis E. Human ovarian tumour-derived chaperone-rich cell lysate (CRCL) elicits T cell responses in vitro. Clin Exp Immunol. 2007 Apr; 148(1):136-45. PMID: 17349014.
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    64. Kislin KL, Marron MT, Li G, Graner MW, Katsanis E. Chaperone-rich cell lysate embedded with BCR-ABL peptide demonstrates enhanced anti-tumor activity against a murine BCR-ABL positive leukemia. FASEB J. 2007 Jul; 21(9):2173-84. PMID: 17327358.
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    65. Sok JC, Coppelli FM, Thomas SM, Lango MN, Xi S, Hunt JL, Freilino ML, Graner MW, Wikstrand CJ, Bigner DD, Gooding WE, Furnari FB, Grandis JR. Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin Cancer Res. 2006 Sep 01; 12(17):5064-73. PMID: 16951222.
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    66. Graner MW, Bigner DD. Therapeutic aspects of chaperones/heat-shock proteins in neuro-oncology. Expert Rev Anticancer Ther. 2006 May; 6(5):679-95. PMID: 16759160.
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    67. Kuan CT, Wakiya K, Dowell JM, Herndon JE, Reardon DA, Graner MW, Riggins GJ, Wikstrand CJ, Bigner DD. Glycoprotein nonmetastatic melanoma protein B, a potential molecular therapeutic target in patients with glioblastoma multiforme. Clin Cancer Res. 2006 Apr 01; 12(7 Pt 1):1970-82. PMID: 16609006.
      View in: PubMed
    68. Chen X, Zeng Y, Li G, Larmonier N, Graner MW, Katsanis E. Peritransplantation vaccination with chaperone-rich cell lysate induces antileukemia immunity. Biol Blood Marrow Transplant. 2006 Mar; 12(3):275-83. PMID: 16503496.
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    69. Rich JN, Sathornsumetee S, Keir ST, Kieran MW, Laforme A, Kaipainen A, McLendon RE, Graner MW, Rasheed BK, Wang L, Reardon DA, Ryan AJ, Wheeler C, Dimery I, Bigner DD, Friedman HS. ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors. Clin Cancer Res. 2005 Nov 15; 11(22):8145-57. PMID: 16299247.
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    70. Ramanathapuram LV, Hahn T, Graner MW, Katsanis E, Akporiaye ET. Vesiculated alpha-tocopheryl succinate enhances the anti-tumor effect of dendritic cell vaccines. Cancer Immunol Immunother. 2006 Feb; 55(2):166-77. PMID: 16041582.
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    71. Graner MW, Bigner DD. Chaperone proteins and brain tumors: potential targets and possible therapeutics. Neuro Oncol. 2005 Jul; 7(3):260-78. PMID: 16053701.
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    72. Zeng Y, Graner MW, Katsanis E. Chaperone-rich cell lysates, immune activation and tumor vaccination. Cancer Immunol Immunother. 2006 Mar; 55(3):329-38. PMID: 15887013.
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    73. Graner MW, Likhacheva A, Davis J, Raymond A, Brandenberger J, Romanoski A, Thompson S, Akporiaye E, Katsanis E. Cargo from tumor-expressed albumin inhibits T-cell activation and responses. Cancer Res. 2004 Nov 01; 64(21):8085-92. PMID: 15520220.
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    74. Zeng Y, Graner MW, Thompson S, Marron M, Katsanis E. Induction of BCR-ABL-specific immunity following vaccination with chaperone-rich cell lysates derived from BCR-ABL+ tumor cells. Blood. 2005 Mar 01; 105(5):2016-22. PMID: 15374884.
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    75. Zeng Y, Graner MW, Feng H, Li G, Katsanis E. Imatinib mesylate effectively combines with chaperone-rich cell lysate-loaded dendritic cells to treat bcr-abl+ murine leukemia. Int J Cancer. 2004 Jun 10; 110(2):251-9. PMID: 15069690.
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    76. Feng H, Zeng Y, Graner MW, Whitesell L, Katsanis E. Evidence for a Novel, Caspase-8-Independent, Fas Death Domain-Mediated Apoptotic Pathway. J Biomed Biotechnol. 2004; 2004(1):41-51. PMID: 15123887.
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    77. Raynes DA, Graner MW, Bagatell R, McLellan C, Guerriero V. Increased expression of the Hsp70 cochaperone HspBP1 in tumors. Tumour Biol. 2003 Nov-Dec; 24(6):281-5. PMID: 15004487.
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    78. Graner MW, Zeng Y, Feng H, Katsanis E. Tumor-derived chaperone-rich cell lysates are effective therapeutic vaccines against a variety of cancers. Cancer Immunol Immunother. 2003 Apr; 52(4):226-34. PMID: 12669247.
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    79. Zeng Y, Feng H, Graner MW, Katsanis E. Tumor-derived, chaperone-rich cell lysate activates dendritic cells and elicits potent antitumor immunity. Blood. 2003 Jun 01; 101(11):4485-91. PMID: 12576309.
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    80. Feng H, Zeng Y, Graner MW, Likhacheva A, Katsanis E. Exogenous stress proteins enhance the immunogenicity of apoptotic tumor cells and stimulate antitumor immunity. Blood. 2003 Jan 01; 101(1):245-52. PMID: 12393411.
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    81. Feng H, Zeng Y, Graner MW, Katsanis E. Stressed apoptotic tumor cells stimulate dendritic cells and induce specific cytotoxic T cells. Blood. 2002 Dec 01; 100(12):4108-15. PMID: 12393401.
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    82. He L, Feng H, Raymond A, Kreeger M, Zeng Y, Graner M, Whitesell L, Katsanis E. Dendritic-cell-peptide immunization provides immunoprotection against bcr-abl-positive leukemia in mice. Cancer Immunol Immunother. 2001 Mar; 50(1):31-40. PMID: 11315508.
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    83. Graner M, Raymond A, Akporiaye E, Katsanis E. Tumor-derived multiple chaperone enrichment by free-solution isoelectric focusing yields potent antitumor vaccines. Cancer Immunol Immunother. 2000 Nov; 49(9):476-84. PMID: 11092614.
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    84. Graner M, Raymond A, Romney D, He L, Whitesell L, Katsanis E. Immunoprotective activities of multiple chaperone proteins isolated from murine B-cell leukemia/lymphoma. Clin Cancer Res. 2000 Mar; 6(3):909-15. PMID: 10741715.
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    85. Graner MW, Bunch TA, Baumgartner S, Kerschen A, Brower DL. Splice variants of the Drosophila PS2 integrins differentially interact with RGD-containing fragments of the extracellular proteins tiggrin, ten-m, and D-laminin 2. J Biol Chem. 1998 Jul 17; 273(29):18235-41. PMID: 9660786.
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    86. Bunch TA, Graner MW, Fessler LI, Fessler JH, Schneider KD, Kerschen A, Choy LP, Burgess BW, Brower DL. The PS2 integrin ligand tiggrin is required for proper muscle function in Drosophila. Development. 1998 May; 125(9):1679-89. PMID: 9521906.
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