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Peter James Dempsey

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
    Collapse research activities and funding
    R01DK059778     (DEMPSEY, PETER J)Sep 1, 2000 - Aug 31, 2006
    NIH/NIDDK
    Processing of EGF Ligands in Gut Biology and Cancer
    Role: Principal Investigator

    R01DK063363     (DEMPSEY, PETER J)Sep 30, 2002 - Jun 30, 2008
    NIH/NIDDK
    Endogenous Betacellulin Signaling in Beta-cell Biology
    Role: Principal Investigator

    R41CA139856     (DEMPSEY, PETER J)Aug 1, 2009 - Jul 31, 2010
    NIH/NCI
    Development of ADAM10 Prodomain as a Therapeutic Agent
    Role: Principal Investigator

    R01DK093697     (DEMPSEY, PETER J)Jul 1, 2012 - Jun 30, 2017
    NIH/NIDDK
    ADAM10 in Intestinal Homeostasis and Regeneration
    Role: Principal Investigator

    R21HD092916     (DEMPSEY, PETER J)Sep 1, 2017 - Aug 31, 2019
    NIH/NICHD
    Role of ADAM17 signaling axis in human intestinal homeostasis: Studies on intestinal programming using iPSC cells derived from a patient harboring an autosomal recessive ADAM17 null mutation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dempsey PJ. Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis. Biochim Biophys Acta. 2017 Jul 22. PMID: 28739265.
      View in: PubMed
    2. Schumacher MA, Hedl M, Abraham C, Bernard JK, Lozano PR, Hsieh JJ, Almohazey D, Bucar EB, Punit S, Dempsey PJ, Frey MR. ErbB4 signaling stimulates pro-inflammatory macrophage apoptosis and limits colonic inflammation. Cell Death Dis. 2017 Feb 23; 8(2):e2622. PMID: 28230865.
      View in: PubMed
    3. Feng Y, Demehri FR, Xiao W, Tsai YH, Jones JC, Brindley CD, Threadgill DW, Holst JJ, Hartmann B, Barrett TA, Teitelbaum DH, Dempsey PJ. Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Cell Mol Gastroenterol Hepatol. 2017 May; 3(3):447-468. PMID: 28462383.
      View in: PubMed
    4. Jones JC, Dempsey PJ. Enterocyte progenitors can dedifferentiate to replace lost Lgr5+ intestinal stem cells revealing that many different progenitor populations can regain stemness. Stem Cell Investig. 2016; 3:61. PMID: 27868043.
      View in: PubMed
    5. Dempsey PJ. Are Facultative Reserve ISCs the Cellular Origin of Familial Small Intestinal Neuroendocrine Tumors? Gastroenterology. 2016 Jul; 151(1):27-9. PMID: 27237596.
      View in: PubMed
    6. Jones JC, Rustagi S, Dempsey PJ. ADAM Proteases and Gastrointestinal Function. Annu Rev Physiol. 2016; 78:243-76. PMID: 26667078; PMCID: PMC4927194.
    7. Feng Y, Tsai YH, Xiao W, Ralls MW, Stoeck A, Wilson CL, Raines EW, Teitelbaum DH, Dempsey PJ. Loss of ADAM17-Mediated Tumor Necrosis Factor Alpha Signaling in Intestinal Cells Attenuates Mucosal Atrophy in a Mouse Model of Parenteral Nutrition. Mol Cell Biol. 2015 Nov; 35(21):3604-21. PMID: 26283731; PMCID: PMC4589604.
    8. Finkbeiner SR, Hill DR, Altheim CH, Dedhia PH, Taylor MJ, Tsai YH, Chin AM, Mahe MM, Watson CL, Freeman JJ, Nattiv R, Thomson M, Klein OD, Shroyer NF, Helmrath MA, Teitelbaum DH, Dempsey PJ, Spence JR. Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports. 2015 Jun 03. PMID: 26050928.
      View in: PubMed
    9. Freeman JJ, Feng Y, Demehri FR, Dempsey PJ, Teitelbaum DH. TPN-associated intestinal epithelial cell atrophy is modulated by TLR4/EGF signaling pathways. FASEB J. 2015 Jul; 29(7):2943-58. PMID: 25782989; PMCID: PMC4478799.
    10. Klingener M, Chavali M, Singh J, McMillan N, Coomes A, Dempsey PJ, Chen EI, Aguirre A. N-cadherin promotes recruitment and migration of neural progenitor cells from the SVZ neural stem cell niche into demyelinated lesions. J Neurosci. 2014 Jul 16; 34(29):9590-606. PMID: 25031401; PMCID: PMC4099541.
    11. Tsai YH, VanDussen KL, Sawey ET, Wade AW, Kasper C, Rakshit S, Bhatt RG, Stoeck A, Maillard I, Crawford HC, Samuelson LC, Dempsey PJ. ADAM10 regulates Notch function in intestinal stem cells of mice. Gastroenterology. 2014 Oct; 147(4):822-834.e13. PMID: 25038433; PMCID: PMC4176890.
    12. Dempsey PJ. Jay J. Listinsky, MD, PhD. Radiology. 2014 May; 271(2):621. PMID: 24761961.
      View in: PubMed
    13. Middleton LP, Sneige N, Coyne R, Shen Y, Dong W, Dempsey P, Bevers TB. Most lobular carcinoma in situ and atypical lobular hyperplasia diagnosed on core needle biopsy can be managed clinically with radiologic follow-up in a multidisciplinary setting. Cancer Med. 2014 Jun; 3(3):492-9. PMID: 24639339; PMCID: PMC4101740.
    14. Yan F, Liu L, Dempsey PJ, Tsai YH, Raines EW, Wilson CL, Cao H, Cao Z, Liu L, Polk DB. A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. J Biol Chem. 2013 Oct 18; 288(42):30742-51. PMID: 24043629; PMCID: PMC3798544.
    15. Guy CS, Vignali KM, Temirov J, Bettini ML, Overacre AE, Smeltzer M, Zhang H, Huppa JB, Tsai YH, Lobry C, Xie J, Dempsey PJ, Crawford HC, Aifantis I, Davis MM, Vignali DA. Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol. 2013 Mar; 14(3):262-70. PMID: 23377202; PMCID: PMC3577985.
    16. Colombo A, Wang H, Kuhn PH, Page R, Kremmer E, Dempsey PJ, Crawford HC, Lichtenthaler SF. Constitutive a- and ß-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines. Neurobiol Dis. 2013 Jan; 49:137-47. PMID: 22940630; PMCID: PMC4310234.
    17. VanDussen KL, Carulli AJ, Keeley TM, Patel SR, Puthoff BJ, Magness ST, Tran IT, Maillard I, Siebel C, Kolterud Å, Grosse AS, Gumucio DL, Ernst SA, Tsai YH, Dempsey PJ, Samuelson LC. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development. 2012 Feb; 139(3):488-97. PMID: 22190634; PMCID: PMC3252352.
    18. Hilliard VC, Frey MR, Dempsey PJ, Peek RM, Polk DB. TNF-a converting enzyme-mediated ErbB4 transactivation by TNF promotes colonic epithelial cell survival. Am J Physiol Gastrointest Liver Physiol. 2011 Aug; 301(2):G338-46. PMID: 21617117; PMCID: PMC3154600.
    19. Sharabi SE, Bullocks JM, Dempsey PJ, Singletary SE. The need for breast cancer screening in women undergoing elective breast surgery: an assessment of risk and risk factors for breast cancer in young women. Aesthet Surg J. 2010 Nov-Dec; 30(6):821-31. PMID: 21131456.
      View in: PubMed
    20. Wicksteed B, Brissova M, Yan W, Opland DM, Plank JL, Reinert RB, Dickson LM, Tamarina NA, Philipson LH, Shostak A, Bernal-Mizrachi E, Elghazi L, Roe MW, Labosky PA, Myers MG, Gannon M, Powers AC, Dempsey PJ. Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain. Diabetes. 2010 Dec; 59(12):3090-8. PMID: 20802254; PMCID: PMC2992770.
    21. Stoeck A, Shang L, Dempsey PJ. Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth. J Cell Sci. 2010 Jul 01; 123(Pt 13):2319-31. PMID: 20530572; PMCID: PMC2886747.
    22. Moss ML, Rasmussen FH, Nudelman R, Dempsey PJ, Williams J. Fluorescent substrates useful as high-throughput screening tools for ADAM9. Comb Chem High Throughput Screen. 2010 May; 13(4):358-65. PMID: 20015014.
      View in: PubMed
    23. Cheng X, Jin J, Hu L, Shen D, Dong XP, Samie MA, Knoff J, Eisinger B, Liu ML, Huang SM, Caterina MJ, Dempsey P, Michael LE, Dlugosz AA, Andrews NC, Clapham DE, Xu H. TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. Cell. 2010 Apr 16; 141(2):331-43. PMID: 20403327; PMCID: PMC2858065.
    24. Dempsey PJ. New ultrasound-based imaging technologies are claimed to avoid unnecessary breast biopsies, but what is an "unnecessary" image-guided needle biopsy of the breast? J Clin Ultrasound. 2010 Mar-Apr; 38(3):111-2. PMID: 20014014.
      View in: PubMed
    25. Gibb DR, El Shikh M, Kang DJ, Rowe WJ, El Sayed R, Cichy J, Yagita H, Tew JG, Dempsey PJ, Crawford HC, Conrad DH. ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo. J Exp Med. 2010 Mar 15; 207(3):623-35. PMID: 20156974; PMCID: PMC2839139.
    26. Bevers TB, Anderson BO, Bonaccio E, Buys S, Buys S, Daly MB, Dempsey PJ, Farrar WB, Fleming I, Garber JE, Harris RE, Heerdt AS, Helvie M, Huff JG, Khakpour N, Khan SA, Krontiras H, Lyman G, Rafferty E, Shaw S, Smith ML, Tsangaris TN, Williams C, Yankeelov T, Yaneeklov T. NCCN clinical practice guidelines in oncology: breast cancer screening and diagnosis. J Natl Compr Canc Netw. 2009 Nov; 7(10):1060-96. PMID: 19930975.
      View in: PubMed
    27. Yan F, Cao H, Chaturvedi R, Krishna U, Hobbs SS, Dempsey PJ, Peek RM, Cover TL, Washington MK, Wilson KT, Polk DB. Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis. Gastroenterology. 2009 Apr; 136(4):1297-1307, e1-3. PMID: 19250983; PMCID: PMC2878739.
    28. Crawford HC, Dempsey PJ, Brown G, Adam L, Moss ML. ADAM10 as a therapeutic target for cancer and inflammation. Curr Pharm Des. 2009; 15(20):2288-99. PMID: 19601831.
      View in: PubMed
    29. Gelling RW, Yan W, Al-Noori S, Pardini A, Morton GJ, Ogimoto K, Schwartz MW, Dempsey PJ. Deficiency of TNFalpha converting enzyme (TACE/ADAM17) causes a lean, hypermetabolic phenotype in mice. Endocrinology. 2008 Dec; 149(12):6053-64. PMID: 18687778; PMCID: PMC2734496.
    30. Sanderson MP, Keller S, Alonso A, Riedle S, Dempsey PJ, Altevogt P. Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion. J Cell Biochem. 2008 Apr 15; 103(6):1783-97. PMID: 17910038; PMCID: PMC4922250.
    31. Haygood TM, Whitman GJ, Atkinson EN, Nikolova RG, Sandoval SY, Dempsey PJ. Results of a survey on digital screening mammography: prevalence, efficiency, and use of ancillary diagnostic AIDS. J Am Coll Radiol. 2008 Apr; 5(4):585-92. PMID: 18359447.
      View in: PubMed
    32. Merchant NB, Voskresensky I, Rogers CM, Lafleur B, Dempsey PJ, Graves-Deal R, Revetta F, Foutch AC, Rothenberg ML, Washington MK, Coffey RJ. TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Clin Cancer Res. 2008 Feb 15; 14(4):1182-91. PMID: 18281553; PMCID: PMC3718282.
    33. Moss ML, Stoeck A, Yan W, Dempsey PJ. ADAM10 as a target for anti-cancer therapy. Curr Pharm Biotechnol. 2008 Feb; 9(1):2-8. PMID: 18289051.
      View in: PubMed
    34. Nakashima H, Frank GD, Shirai H, Hinoki A, Higuchi S, Ohtsu H, Eguchi K, Sanjay A, Reyland ME, Dempsey PJ, Inagami T, Eguchi S. Novel role of protein kinase C-delta Tyr 311 phosphorylation in vascular smooth muscle cell hypertrophy by angiotensin II. Hypertension. 2008 Feb; 51(2):232-8. PMID: 18180404; PMCID: PMC2728048.
    35. Yang WT, Dryden M, Broglio K, Gilcrease M, Dawood S, Dempsey PJ, Valero V, Hortobagyi G, Atchley D, Arun B. Mammographic features of triple receptor-negative primary breast cancers in young premenopausal women. Breast Cancer Res Treat. 2008 Oct; 111(3):405-10. PMID: 18026834.
      View in: PubMed
    36. Boughey JC, Middleton LP, Harker L, Garrett B, Fornage B, Hunt KK, Babiera GV, Dempsey P, Bedrosian I. Utility of ultrasound and fine-needle aspiration biopsy of the axilla in the assessment of invasive lobular carcinoma of the breast. Am J Surg. 2007 Oct; 194(4):450-5. PMID: 17826054.
      View in: PubMed
    37. Moss ML, Bomar M, Liu Q, Sage H, Dempsey P, Lenhart PM, Gillispie PA, Stoeck A, Wildeboer D, Bartsch JW, Palmisano R, Zhou P. The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events. J Biol Chem. 2007 Dec 07; 282(49):35712-21. PMID: 17895248.
      View in: PubMed
    38. Yang W, Dempsey PJ. Diagnostic breast ultrasound: current status and future directions. Radiol Clin North Am. 2007 Sep; 45(5):845-61, vii. PMID: 17888773.
      View in: PubMed
    39. Li N, Boyd K, Dempsey PJ, Vignali DA. Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development. J Immunol. 2007 Apr 01; 178(7):4214-21. PMID: 17371977.
      View in: PubMed
    40. Li N, Wang Y, Forbes K, Vignali KM, Heale BS, Saftig P, Hartmann D, Black RA, Rossi JJ, Blobel CP, Dempsey PJ, Workman CJ, Vignali DA. Metalloproteases regulate T-cell proliferation and effector function via LAG-3. EMBO J. 2007 Jan 24; 26(2):494-504. PMID: 17245433; PMCID: PMC1783452.
    41. Yang WT, Lai CJ, Whitman GJ, Murphy WA, Dryden MJ, Kushwaha AC, Sahin AA, Johnston D, Dempsey PJ, Shaw CC. Comparison of full-field digital mammography and screen-film mammography for detection and characterization of simulated small masses. AJR Am J Roentgenol. 2006 Dec; 187(6):W576-81. PMID: 17114508; PMCID: PMC1892902.
    42. Sanderson MP, Abbott CA, Tada H, Seno M, Dempsey PJ, Dunbar AJ. Hydrogen peroxide and endothelin-1 are novel activators of betacellulin ectodomain shedding. J Cell Biochem. 2006 Oct 01; 99(2):609-23. PMID: 16676357.
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    43. Hess KR, Anderson K, Symmans WF, Valero V, Ibrahim N, Mejia JA, Booser D, Theriault RL, Buzdar AU, Dempsey PJ, Rouzier R, Sneige N, Ross JS, Vidaurre T, Gómez HL, Hortobagyi GN, Pusztai L. Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer. J Clin Oncol. 2006 Sep 10; 24(26):4236-44. PMID: 16896004.
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    44. Erguvan-Dogan B, Whitman GJ, Kushwaha AC, Phelps MJ, Dempsey PJ. BI-RADS-MRI: a primer. AJR Am J Roentgenol. 2006 Aug; 187(2):W152-60. PMID: 16861504.
      View in: PubMed
    45. Lai CJ, Shaw CC, Whitman GJ, Yang WT, Dempsey PJ, Nguyen V, Ice MF. Receiver operating characteristic analysis for the detection of simulated microcalcifications on mammograms using hardcopy images. Phys Med Biol. 2006 Aug 21; 51(16):3901-19. PMID: 16885614; PMCID: PMC1913688.
    46. Ohtsu H, Dempsey PJ, Frank GD, Brailoiu E, Higuchi S, Suzuki H, Nakashima H, Eguchi K, Eguchi S. ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II. Arterioscler Thromb Vasc Biol. 2006 Sep; 26(9):e133-7. PMID: 16840716.
      View in: PubMed
    47. Ohtsu H, Dempsey PJ, Eguchi S. ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. Am J Physiol Cell Physiol. 2006 Jul; 291(1):C1-10. PMID: 16769815.
      View in: PubMed
    48. Sanderson MP, Dempsey PJ, Dunbar AJ. Control of ErbB signaling through metalloprotease mediated ectodomain shedding of EGF-like factors. Growth Factors. 2006 Jun; 24(2):121-36. PMID: 16801132.
      View in: PubMed
    49. Bevers TB, Anderson BO, Bonaccio E, Borgen PI, Buys S, Daly MB, Dempsey PJ, Farrar WB, Fleming I, Garber JE, Harris RE, Helvie M, Hoover S, Krontiras H, Shaw S, Singletary E, Sugg Skinner C, Smith ML, Tsangaris TN, Wiley EL, Williams C. Breast cancer screening and diagnosis. J Natl Compr Canc Netw. 2006 May; 4(5):480-508. PMID: 16687096.
      View in: PubMed
    50. Chagpar AB, Middleton LP, Sahin AA, Dempsey P, Buzdar AU, Mirza AN, Ames FC, Babiera GV, Feig BW, Hunt KK, Kuerer HM, Meric-Bernstam F, Ross MI, Singletary SE. Accuracy of physical examination, ultrasonography, and mammography in predicting residual pathologic tumor size in patients treated with neoadjuvant chemotherapy. Ann Surg. 2006 Feb; 243(2):257-64. PMID: 16432360; PMCID: PMC1448900.
    51. Erguvan-Dogan B, Dempsey PJ, Ayyar G, Gilcrease MZ. Primary desmoid tumor (extraabdominal fibromatosis) of the breast. AJR Am J Roentgenol. 2005 Aug; 185(2):488-9. PMID: 16037525.
      View in: PubMed
    52. Mifune M, Ohtsu H, Suzuki H, Nakashima H, Brailoiu E, Dun NJ, Frank GD, Inagami T, Higashiyama S, Thomas WG, Eckhart AD, Dempsey PJ, Eguchi S. G protein coupling and second messenger generation are indispensable for metalloprotease-dependent, heparin-binding epidermal growth factor shedding through angiotensin II type-1 receptor. J Biol Chem. 2005 Jul 15; 280(28):26592-9. PMID: 15905175.
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    53. Franklin JL, Yoshiura K, Dempsey PJ, Bogatcheva G, Jeyakumar L, Meise KS, Pearsall RS, Threadgill D, Coffey RJ. Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. Exp Cell Res. 2005 Feb 15; 303(2):457-70. PMID: 15652357.
      View in: PubMed
    54. Sanderson MP, Erickson SN, Gough PJ, Garton KJ, Wille PT, Raines EW, Dunbar AJ, Dempsey PJ. ADAM10 mediates ectodomain shedding of the betacellulin precursor activated by p-aminophenylmercuric acetate and extracellular calcium influx. J Biol Chem. 2005 Jan 21; 280(3):1826-37. PMID: 15507448.
      View in: PubMed
    55. Selinko VL, Middleton LP, Dempsey PJ. Role of sonography in diagnosing and staging invasive lobular carcinoma. J Clin Ultrasound. 2004 Sep; 32(7):323-32. PMID: 15293298.
      View in: PubMed
    56. Dempsey PJ. The history of breast ultrasound. J Ultrasound Med. 2004 Jul; 23(7):887-94. PMID: 15292555.
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    57. Mifune M, Ohtsu H, Suzuki H, Frank GD, Inagami T, Utsunomiya H, Dempsey PJ, Eguchi S. Signal transduction of betacellulin in growth and migration of vascular smooth muscle cells. Am J Physiol Cell Physiol. 2004 Sep; 287(3):C807-13. PMID: 15163624.
      View in: PubMed
    58. Yang WT, Whitman GJ, Johnson MM, Bolanos-Clark M, Kushwaha AC, Hunt KK, Dempsey PJ. Needle localization for excisional biopsy of breast lesions: comparison of effect of use of full-field digital versus screen-film mammographic guidance on procedure time. Radiology. 2004 Apr; 231(1):277-81. PMID: 15068954.
      View in: PubMed
    59. Gough PJ, Garton KJ, Wille PT, Rychlewski M, Dempsey PJ, Raines EW. A disintegrin and metalloproteinase 10-mediated cleavage and shedding regulates the cell surface expression of CXC chemokine ligand 16. J Immunol. 2004 Mar 15; 172(6):3678-85. PMID: 15004171.
      View in: PubMed
    60. Madigan MN, Dempsey PJ, Krishnamurthy S. Ultrasound-guided fine needle aspiration cytodiagnosis of leiomyosarcoma metastatic to the breast. A case report. Acta Cytol. 2003 Sep-Oct; 47(5):783-6. PMID: 14526679.
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    61. Garton KJ, Gough PJ, Philalay J, Wille PT, Blobel CP, Whitehead RH, Dempsey PJ, Raines EW. Stimulated shedding of vascular cell adhesion molecule 1 (VCAM-1) is mediated by tumor necrosis factor-alpha-converting enzyme (ADAM 17). J Biol Chem. 2003 Sep 26; 278(39):37459-64. PMID: 12878595.
      View in: PubMed
    62. Dempsey PJ, Meise KS, Coffey RJ. Basolateral sorting of transforming growth factor-alpha precursor in polarized epithelial cells: characterization of cytoplasmic domain determinants. Exp Cell Res. 2003 May 01; 285(2):159-74. PMID: 12706112.
      View in: PubMed
    63. Frank GD, Mifune M, Inagami T, Ohba M, Sasaki T, Higashiyama S, Dempsey PJ, Eguchi S. Distinct mechanisms of receptor and nonreceptor tyrosine kinase activation by reactive oxygen species in vascular smooth muscle cells: role of metalloprotease and protein kinase C-delta. Mol Cell Biol. 2003 Mar; 23(5):1581-9. PMID: 12588978; PMCID: PMC151697.
    64. Saito S, Frank GD, Motley ED, Dempsey PJ, Utsunomiya H, Inagami T, Eguchi S. Metalloprotease inhibitor blocks angiotensin II-induced migration through inhibition of epidermal growth factor receptor transactivation. Biochem Biophys Res Commun. 2002 Jun 28; 294(5):1023-9. PMID: 12074579.
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    65. Dempsey PJ, Garton K, Raines EW. Emerging roles of TACE as a key protease in ErbB ligand shedding. Mol Interv. 2002 Jun; 2(3):136-41. PMID: 14993373.
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    66. Garton KJ, Gough PJ, Blobel CP, Murphy G, Greaves DR, Dempsey PJ, Raines EW. Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem. 2001 Oct 12; 276(41):37993-8001. PMID: 11495925.
      View in: PubMed
    67. Brown CL, Coffey RJ, Dempsey PJ. The proamphiregulin cytoplasmic domain is required for basolateral sorting, but is not essential for constitutive or stimulus-induced processing in polarized Madin-Darby canine kidney cells. J Biol Chem. 2001 Aug 03; 276(31):29538-49. PMID: 11382759.
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    68. Rubin E, Mennemeyer ST, Desmond RA, Urist MM, Waterbor J, Heslin MJ, Bernreuter WK, Dempsey PJ, Pile NS, Rodgers WH. Reducing the cost of diagnosis of breast carcinoma: impact of ultrasound and imaging-guided biopsies on a clinical breast practice. Cancer. 2001 Jan 15; 91(2):324-32. PMID: 11180078.
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    69. Fischbein MP, Ardehali A, Yun J, Schoenberger S, Laks H, Irie Y, Dempsey P, Cheng G, Fishbein MC, Bonavida B. CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants. J Immunol. 2000 Dec 15; 165(12):7316-22. PMID: 11120867.
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    70. Eguchi S, Dempsey PJ, Frank GD, Motley ED, Inagami T. Activation of MAPKs by angiotensin II in vascular smooth muscle cells. Metalloprotease-dependent EGF receptor activation is required for activation of ERK and p38 MAPK but not for JNK. J Biol Chem. 2001 Mar 16; 276(11):7957-62. PMID: 11116149.
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    71. Denning MF, Dlugosz AA, Cheng C, Dempsey PJ, Coffey RJ, Threadgill DW, Magnuson T, Yuspa SH. Cross-talk between epidermal growth factor receptor and protein kinase C during calcium-induced differentiation of keratinocytes. Exp Dermatol. 2000 Jun; 9(3):192-9. PMID: 10839717.
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    72. Donaldson JC, Dempsey PJ, Reddy S, Bouton AH, Coffey RJ, Hanks SK. Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells. Exp Cell Res. 2000 Apr 10; 256(1):168-78. PMID: 10739664.
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    73. Damstrup L, Kuwada SK, Dempsey PJ, Brown CL, Hawkey CJ, Poulsen HS, Wiley HS, Coffey RJ. Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis. Br J Cancer. 1999 Jun; 80(7):1012-9. PMID: 10362109; PMCID: PMC2363033.
    74. Dong J, Opresko LK, Dempsey PJ, Lauffenburger DA, Coffey RJ, Wiley HS. Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. Proc Natl Acad Sci U S A. 1999 May 25; 96(11):6235-40. PMID: 10339571; PMCID: PMC26865.
    75. Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, Roden MM, Belas F, Chaudhary AK, Roden DM, Wood AJ, Wilkinson GR. Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999 Mar; 16(3):408-14. PMID: 10213372.
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    76. Butler RS, Venta LA, Wiley EL, Ellis RL, Dempsey PJ, Rubin E. Sonographic evaluation of infiltrating lobular carcinoma. AJR Am J Roentgenol. 1999 Feb; 172(2):325-30. PMID: 9930776.
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    77. Bassett LW, Cardenosa G, D'Orsi CJ, Dempsey PJ, Dershaw DD, Destouet JM, Evans WP, Feig SA, Hendrick RE, Jackson VP, Kopans DB, Linver MN, Mendelson EB, Monsees B, Racenstein MJ, Sickles EA, Stelling CB, Warren L. Risk of risk-based mammography screening, ages 40 to 49. American College of Radiology Task Force on Breast Cancer. J Clin Oncol. 1999 Feb; 17(2):735-8. PMID: 10080624.
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    78. Kuwada SK, Li XF, Damstrup L, Dempsey PJ, Coffey RJ, Wiley HS. The dynamic expression of the epidermal growth factor receptor and epidermal growth factor ligand family in a differentiating intestinal epithelial cell line. Growth Factors. 1999; 17(2):139-53. PMID: 10595313.
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    79. Zhang R, Averboukh L, Zhu W, Zhang H, Jo H, Dempsey PJ, Coffey RJ, Pardee AB, Liang P. Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation. Mol Cell Biol. 1998 Oct; 18(10):6131-41. PMID: 9742130; PMCID: PMC109199.
    80. Vecchi M, Rudolph-Owen LA, Brown CL, Dempsey PJ, Carpenter G. Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin. J Biol Chem. 1998 Aug 07; 273(32):20589-95. PMID: 9685416.
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    81. Brown CL, Meise KS, Plowman GD, Coffey RJ, Dempsey PJ. Cell surface ectodomain cleavage of human amphiregulin precursor is sensitive to a metalloprotease inhibitor. Release of a predominant N-glycosylated 43-kDa soluble form. J Biol Chem. 1998 Jul 03; 273(27):17258-68. PMID: 9642297.
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    82. Ellis RL, Dempsey PJ, Rubin E, Pile NS, Bernreuter WK. Mammography of breasts in which catheter cuffs have been retained: normal, infected, and postoperative appearances. AJR Am J Roentgenol. 1997 Sep; 169(3):713-5. PMID: 9275884.
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    83. Dempsey PJ, Meise KS, Yoshitake Y, Nishikawa K, Coffey RJ. Apical enrichment of human EGF precursor in Madin-Darby canine kidney cells involves preferential basolateral ectodomain cleavage sensitive to a metalloprotease inhibitor. J Cell Biol. 1997 Aug 25; 138(4):747-58. PMID: 9265643; PMCID: PMC2138042.
    84. Coffey RJ, Hawkey CJ, Damstrup L, Graves-Deal R, Daniel VC, Dempsey PJ, Chinery R, Kirkland SC, DuBois RN, Jetton TL, Morrow JD. Epidermal growth factor receptor activation induces nuclear targeting of cyclooxygenase-2, basolateral release of prostaglandins, and mitogenesis in polarizing colon cancer cells. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):657-62. PMID: 9012840; PMCID: PMC19569.
    85. Rutten MJ, Dempsey PJ, Luttropp CA, Hawkey MA, Sheppard BC, Crass RA, Deveney CW, Coffey RJ. Identification of an EGF/TGF-alpha receptor in primary cultures of guinea pig gastric mucous epithelial cells. Am J Physiol. 1996 Apr; 270(4 Pt 1):G604-12. PMID: 8928790.
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    86. Gangarosa LM, Dempsey PJ, Damstrup L, Barnard JA, Coffey RJ. Transforming growth factor-alpha. Baillieres Clin Gastroenterol. 1996 Mar; 10(1):49-63. PMID: 8732300.
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    87. Coffey RJ, Gangarosa LM, Damstrup L, Dempsey PJ. Basic actions of transforming growth factor-alpha and related peptides. Eur J Gastroenterol Hepatol. 1995 Oct; 7(10):923-7. PMID: 8590135.
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    88. Hayward IP, Whitehead RH, Ward L, Gianello R, Dempsey P, Bates R, Burns GF. Effect of TGF-beta on differentiated organoids of the colon carcinoma cell line LIM 1863. Immunol Cell Biol. 1995 Jun; 73(3):249-57. PMID: 7590899.
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    89. Rubin E, Dempsey PJ, Pile NS, Bernreuter WK, Urist MM, Shumate CR, Maddox WA. Needle-localization biopsy of the breast: impact of a selective core needle biopsy program on yield. Radiology. 1995 Jun; 195(3):627-31. PMID: 7753985.
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    90. Dlugosz AA, Cheng C, Williams EK, Darwiche N, Dempsey PJ, Mann B, Dunn AR, Coffey RJ, Yuspa SH. Autocrine transforming growth factor alpha is dispensible for v-rasHa-induced epidermal neoplasia: potential involvement of alternate epidermal growth factor receptor ligands. Cancer Res. 1995 May 01; 55(9):1883-93. PMID: 7728756.
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    91. Lin CQ, Dempsey PJ, Coffey RJ, Bissell MJ. Extracellular matrix regulates whey acidic protein gene expression by suppression of TGF-alpha in mouse mammary epithelial cells: studies in culture and in transgenic mice. J Cell Biol. 1995 May; 129(4):1115-26. PMID: 7744960; PMCID: PMC2120484.
    92. Dlugosz AA, Cheng C, Denning MF, Dempsey PJ, Coffey RJ, Yuspa SH. Keratinocyte growth factor receptor ligands induce transforming growth factor alpha expression and activate the epidermal growth factor receptor signaling pathway in cultured epidermal keratinocytes. Cell Growth Differ. 1994 Dec; 5(12):1283-92. PMID: 7535082.
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    93. Dempsey PJ, Coffey RJ. Basolateral targeting and efficient consumption of transforming growth factor-alpha when expressed in Madin-Darby canine kidney cells. J Biol Chem. 1994 Jun 17; 269(24):16878-89. PMID: 8207010.
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    94. Coffey RJ, Meise KS, Matsui Y, Hogan BL, Dempsey PJ, Halter SA. Acceleration of mammary neoplasia in transforming growth factor alpha transgenic mice by 7,12-dimethylbenzanthracene. Cancer Res. 1994 Apr 01; 54(7):1678-83. PMID: 8137281.
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    95. Dempsey PJ, Rubin E. Preoperative needle localization in the breast: utility of local anesthesia. Radiology. 1993 Nov; 189(2):623-4. PMID: 8210401.
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    96. Russell WE, Dempsey PJ, Sitaric S, Peck AJ, Coffey RJ. Transforming growth factor-alpha (TGF alpha) concentrations increase in regenerating rat liver: evidence for a delayed accumulation of mature TGF alpha. Endocrinology. 1993 Oct; 133(4):1731-8. PMID: 8404616.
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    97. Rutten MJ, Dempsey PJ, Solomon TE, Coffey RJ. TGF-alpha is a potent mitogen for primary cultures of guinea pig gastric mucous epithelial cells. Am J Physiol. 1993 Aug; 265(2 Pt 1):G361-9. PMID: 8368318.
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    98. Dempsey PJ, Rubin E. The roles of needle biopsy and periodic follow-up in the evaluation and diagnosis of breast lesions. Semin Roentgenol. 1993 Jul; 28(3):252-8. PMID: 8211233.
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    99. Cheng C, Tennenbaum T, Dempsey PJ, Coffey RJ, Yuspa SH, Dlugosz AA. Epidermal growth factor receptor ligands regulate keratin 8 expression in keratinocytes, and transforming growth factor alpha mediates the induction of keratin 8 by the v-rasHa oncogene. Cell Growth Differ. 1993 Apr; 4(4):317-27. PMID: 7684248.
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    100. Dempsey PJ, Goldenring JR, Soroka CJ, Modlin IM, McClure RW, Lind CD, Ahlquist DA, Pittelkow MR, Lee DC, Sandgren EP, et al. Possible role of transforming growth factor alpha in the pathogenesis of Ménétrier's disease: supportive evidence form humans and transgenic mice. Gastroenterology. 1992 Dec; 103(6):1950-63. PMID: 1451986.
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    101. Coffey RJ, Romano M, Polk WH, Dempsey PJ. Roles for transforming growth factor-alpha in gastric physiology and pathophysiology. Yale J Biol Med. 1992 Nov-Dec; 65(6):693-704; discussion 621-3. PMID: 1341072; PMCID: PMC2589761.
    102. Coffey RJ, Graves-Deal R, Dempsey PJ, Whitehead RH, Pittelkow MR. Differential regulation of transforming growth factor alpha autoinduction in a nontransformed and transformed epithelial cell. Cell Growth Differ. 1992 Jun; 3(6):347-54. PMID: 1419897.
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    103. Halter SA, Dempsey P, Matsui Y, Stokes MK, Graves-Deal R, Hogan BL, Coffey RJ. Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-alpha. Characterization of mammary gland and skin proliferations. Am J Pathol. 1992 May; 140(5):1131-46. PMID: 1316084; PMCID: PMC1886506.
    104. Polk WH, Dempsey PJ, Russell WE, Brown PI, Beauchamp RD, Barnard JA, Coffey RJ. Increased production of transforming growth factor alpha following acute gastric injury. Gastroenterology. 1992 May; 102(5):1467-74. PMID: 1568557.
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    105. Nice E, Dempsey P, Layton J, Morstyn G, Cui DF, Simpson R, Fabri L, Burgess A. Human granulocyte-macrophage colony-stimulating factor (hGM-CSF): identification of a binding site for a neutralizing antibody. Growth Factors. 1990; 3(2):159-69. PMID: 1698402.
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    106. Lorino CO, Dempsey PJ. Breast cancer screening in mobile. Ala Med. 1988 Nov; 58(5):23-5. PMID: 3232677.
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    107. Dempsey PJ. The importance of resolution in the clinical application of breast sonography. Ultrasound Med Biol. 1988; 14 Suppl 1:43-8. PMID: 3055600.
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    108. Thorne HJ, Jose DG, Zhang HY, Dempsey PJ, Whitehead RH. Epidermal growth factor stimulates the synthesis of cell-attachment proteins in the human breast cancer cell line PMC42. Int J Cancer. 1987 Aug 15; 40(2):207-12. PMID: 3301692.
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    109. Dempsey PJ, Feleppa FP, Brown RW, de Kretser TA, Whitehead RH, Jose DG. Development of monoclonal antibodies to the human breast carcinoma cell line PMC42. J Natl Cancer Inst. 1986 Jul; 77(1):1-15. PMID: 2425115.
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    110. Dempsey PJ, de Kretser TA, Brown RW, Whitehead RH, Jose DG. A monoclonal antibody CIBr17 recognizes a myoepithelium-specific antigen in human mammary gland. Int J Cancer. 1986 Jun 15; 37(6):857-66. PMID: 3519473.
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    111. Dempsey PJ, Koch HJ. In utero diagnosis of the Dandy-Walker syndrome: differentiation from extra-axial posterior fossa cyst. J Clin Ultrasound. 1981 Sep; 9(7):403-5. PMID: 6792240.
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    112. Phillips JF, Goodwin DW, Thomason SB, Dempsey PJ. The volume of the uterus in normal and abnormal pregnancy. J Clin Ultrasound. 1977 Apr; 5(2):107-10. PMID: 404325.
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    113. Morgan CL, Dempsey PJ, Johnsrude I, Johnson ML. Ultrasound in the diagnosis of xanthogranulomatous pyelonephritis: a case report. J Clin Ultrasound. 1975 Dec; 3(4):301-5. PMID: 829537.
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    114. Dempsey PJ, Goree JA, Jimenez JP, McCord GM. The effect of contrast media on patient motion during cerebral angiography. Radiology. 1975 Apr; 115(1):207-9. PMID: 1090978.
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    115. Sobel BE, Dempsey PJ, Cooper T. Adenyl cyclase activity in the chronically denervated cat heart. Biochem Biophys Res Commun. 1968 Dec 09; 33(5):758-62. PMID: 4301977.
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