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Linda A. Barlow

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Cell and Devopmental Bio
Phone303/724-3438

    Collapse Research 
    Collapse research activities and funding
    R21DC022075     (BARLOW, LINDA A)Aug 1, 2024 - Jul 31, 2026
    NIH
    Development of human taste organoid models
    Role: Principal Investigator
    R01DC021865     (BARLOW, LINDA A)Mar 18, 2024 - Feb 28, 2029
    NIH
    The role of Kit signaling in taste bud regeneration
    Role: Principal Investigator
    R01DC018489     (BARLOW, LINDA A)Jul 1, 2020 - Jun 30, 2025
    NIH
    Characterization of progenitor populations in adult taste epithelium
    Role: Principal Investigator
    R21CA236480     (BARLOW, LINDA A)Aug 1, 2019 - Jul 31, 2021
    NIH
    Use of lingual organoids to screen for the impact of targeted cancer therapies on taste bud renewal
    Role: Principal Investigator
    R13DC017387     (MAINLAND, JOEL D)Jul 1, 2018 - Jun 30, 2019
    NIH
    Emerging Strategies for Treating Chemosensory Disorders
    Role: Co-Principal Investigator
    R01DC012675     (BARLOW, LINDA A)Jul 1, 2012 - Jun 30, 2018
    NIH
    Tissue interactions in taste bud development
    Role: Principal Investigator
    R01DC012383     (BARLOW, LINDA A)Mar 1, 2012 - Feb 28, 2022
    NIH
    Mechanisms of adult taste bud regeneration
    Role: Principal Investigator
    R21DC011713     (BARLOW, LINDA A)Apr 1, 2011 - Mar 31, 2014
    NIH
    PKC delta and cell renewal in irradiated taste epithelium
    Role: Principal Investigator
    R01DC008373     (BARLOW, LINDA A)Apr 1, 2007 - Mar 31, 2013
    NIH
    Molecular mechanisms of taste bud development.
    Role: Principal Investigator
    R21DC005255     (BARLOW, LINDA A)Sep 28, 2001 - Aug 31, 2004
    NIH
    Role of BDNF in development and maintenance of taste bu*
    Role: Principal Investigator
    R01DC003947     (BARLOW, LINDA A)Dec 1, 1998 - Nov 30, 2011
    NIH
    Embryonic development of taste buds.
    Role: Principal Investigator
    R03DC003128     (BARLOW, LINDA A)Dec 1, 1996 - Apr 30, 1999
    NIH
    EMBRYONIC DEVELOPMENT OF TASTE BUD INNERVATION
    Role: Principal Investigator
    F32DC000114     (BARLOW, LINDA A)Dec 1, 1993
    NIH
    EMBRYONIC INDUCTION OF TASTE BUDS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shechtman LA, Scott JK, Larson ED, Isner TJ, Johnson BJ, Gaillard D, Dempsey PJ, Barlow LA. High Sox2 expression predicts taste lineage competency of lingual progenitors in vitro. Development. 2023 02 15; 150(4). PMID: 36794954.
      View in: PubMed
    2. Barlow LA. The sense of taste: Development, regeneration, and dysfunction. WIREs Mech Dis. 2022 05; 14(3):e1547. PMID: 34850604.
      View in: PubMed
    3. Golden EJ, Larson ED, Shechtman LA, Trahan GD, Gaillard D, Fellin TJ, Scott JK, Jones KL, Barlow LA. Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function. Elife. 2021 05 19; 10. PMID: 34009125.
      View in: PubMed
    4. Shechtman LA, Piarowski CM, Scott JK, Golden EJ, Gaillard D, Barlow LA. Generation and Culture of Lingual Organoids Derived from Adult Mouse Taste Stem Cells. J Vis Exp. 2021 04 05; (170). PMID: 33871462.
      View in: PubMed
    5. Finger TE, Barlow LA. Cellular Diversity and Regeneration in Taste Buds. Curr Opin Physiol. 2021 Apr; 20:146-153. PMID: 33615087.
      View in: PubMed
    6. Gaillard D, Barlow LA. A Mechanistic Overview of Taste Bud Maintenance and Impairment in Cancer Therapies. Chem Senses. 2021 01 01; 46. PMID: 33693542.
      View in: PubMed
    7. Mainland JD, Barlow LA, Munger SD, Millar SE, Vergara MN, Jiang P, Schwob JE, Goldstein BJ, Boye SE, Martens JR, Leopold DA, Bartoshuk LM, Doty RL, Hummel T, Pinto JM, Trimmer C, Kelly C, Pribitkin EA, Reed DR. Identifying Treatments for Taste and Smell Disorders: Gaps and Opportunities. Chem Senses. 2020 10 09; 45(7):493-502. PMID: 32556127.
      View in: PubMed
    8. Cooper KW, Brann DH, Farruggia MC, Bhutani S, Pellegrino R, Tsukahara T, Weinreb C, Joseph PV, Larson ED, Parma V, Albers MW, Barlow LA, Datta SR, Di Pizio A. COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. Neuron. 2020 07 22; 107(2):219-233. PMID: 32640192.
      View in: PubMed
    9. Gaillard D, Shechtman LA, Millar SE, Barlow LA. Fractionated head and neck irradiation impacts taste progenitors, differentiated taste cells, and Wnt/?-catenin signaling in adult mice. Sci Rep. 2019 11 29; 9(1):17934. PMID: 31784592.
      View in: PubMed
    10. Castillo-Azofeifa D, Seidel K, Gross L, Golden EJ, Jacquez B, Klein OD, Barlow LA. SOX2 regulation by hedgehog signaling controls adult lingual epithelium homeostasis. Development. 2018 07 17; 145(14). PMID: 29945863.
      View in: PubMed
    11. Jewkes BC, Barlow LA, Delay ER. Effect of Radiation on Sucrose Detection Thresholds of Mice. Chem Senses. 2017 12 25; 43(1):53-58. PMID: 29053803.
      View in: PubMed
    12. Gaillard D, Bowles SG, Salcedo E, Xu M, Millar SE, Barlow LA. ?-catenin is required for taste bud cell renewal and behavioral taste perception in adult mice. PLoS Genet. 2017 Aug; 13(8):e1006990. PMID: 28846687.
      View in: PubMed
    13. Castillo-Azofeifa D, Losacco JT, Salcedo E, Golden EJ, Finger TE, Barlow LA. Sonic hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance. Development. 2017 09 01; 144(17):3054-3065. PMID: 28743797.
      View in: PubMed
    14. Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kaestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nat Commun. 2017 06 07; 8:15397. PMID: 28589954.
      View in: PubMed
    15. Thirumangalathu S, Barlow LA. ?-Catenin signaling regulates temporally discrete phases of anterior taste bud development. Development. 2015 Dec 15; 142(24):4309-17. PMID: 26525674.
      View in: PubMed
    16. Barlow LA. Progress and renewal in gustation: new insights into taste bud development. Development. 2015 Nov 01; 142(21):3620-9. PMID: 26534983.
      View in: PubMed
    17. Gaillard D, Xu M, Liu F, Millar SE, Barlow LA. ?-Catenin Signaling Biases Multipotent Lingual Epithelial Progenitors to Differentiate and Acquire Specific Taste Cell Fates. PLoS Genet. 2015 May; 11(5):e1005208. PMID: 26020789.
      View in: PubMed
    18. Barlow LA, Klein OD. Developing and regenerating a sense of taste. Curr Top Dev Biol. 2015; 111:401-19. PMID: 25662267.
      View in: PubMed
    19. Castillo D, Seidel K, Salcedo E, Ahn C, de Sauvage FJ, Klein OD, Barlow LA. Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium. Development. 2014 Aug; 141(15):2993-3002. PMID: 24993944.
      View in: PubMed
    20. Miura H, Scott JK, Harada S, Barlow LA. Sonic hedgehog-expressing basal cells are general post-mitotic precursors of functional taste receptor cells. Dev Dyn. 2014 Oct; 243(10):1286-97. PMID: 24590958.
      View in: PubMed
    21. Kapsimali M, Barlow LA. Developing a sense of taste. Semin Cell Dev Biol. 2013 Mar; 24(3):200-9. PMID: 23182899.
      View in: PubMed
    22. Nguyen HM, Reyland ME, Barlow LA. Mechanisms of taste bud cell loss after head and neck irradiation. J Neurosci. 2012 Mar 07; 32(10):3474-84. PMID: 22399770.
      View in: PubMed
    23. Petersen CI, Jheon AH, Mostowfi P, Charles C, Ching S, Thirumangalathu S, Barlow LA, Klein OD. FGF signaling regulates the number of posterior taste papillae by controlling progenitor field size. PLoS Genet. 2011 Jun; 7(6):e1002098. PMID: 21655085.
      View in: PubMed
    24. Gaillard D, Barlow LA. Taste bud cells of adult mice are responsive to Wnt/?-catenin signaling: implications for the renewal of mature taste cells. Genesis. 2011 Apr; 49(4):295-306. PMID: 21328519.
      View in: PubMed
    25. Harlow DE, Yang H, Williams T, Barlow LA. Epibranchial placode-derived neurons produce BDNF required for early sensory neuron development. Dev Dyn. 2011 Feb; 240(2):309-23. PMID: 21246648.
      View in: PubMed
    26. Nguyen HM, Barlow LA. Differential expression of a BMP4 reporter allele in anterior fungiform versus posterior circumvallate taste buds of mice. BMC Neurosci. 2010 Oct 13; 11:129. PMID: 20942907.
      View in: PubMed
    27. Miura H, Barlow LA. Taste bud regeneration and the search for taste progenitor cells. Arch Ital Biol. 2010 Jun; 148(2):107-18. PMID: 20830973.
      View in: PubMed
    28. Barlow LA, Calof AL. Symposium overview: Stem cells in sensory epithelium development and regeneration. Ann N Y Acad Sci. 2009 Jul; 1170:5-6. PMID: 19686097.
      View in: PubMed
    29. Thirumangalathu S, Barlow LA. In vivo fate tracing studies of mammalian taste cell progenitors. Ann N Y Acad Sci. 2009 Jul; 1170:34-8. PMID: 19686103.
      View in: PubMed
    30. Thirumangalathu S, Harlow DE, Driskell AL, Krimm RF, Barlow LA. Fate mapping of mammalian embryonic taste bud progenitors. Development. 2009 May; 136(9):1519-28. PMID: 19363153.
      View in: PubMed
    31. Harlow DE, Barlow LA. Embryonic origin of gustatory cranial sensory neurons. Dev Biol. 2007 Oct 15; 310(2):317-28. PMID: 17826760.
      View in: PubMed
    32. Liu F, Thirumangalathu S, Gallant NM, Yang SH, Stoick-Cooper CL, Reddy ST, Andl T, Taketo MM, Dlugosz AA, Moon RT, Barlow LA, Millar SE. Wnt-beta-catenin signaling initiates taste papilla development. Nat Genet. 2007 Jan; 39(1):106-12. PMID: 17128274.
      View in: PubMed
    33. Seta Y, Stoick-Cooper CL, Toyono T, Kataoka S, Toyoshima K, Barlow LA. The bHLH transcription factors, Hes6 and Mash1, are expressed in distinct subsets of cells within adult mouse taste buds. Arch Histol Cytol. 2006 Sep; 69(3):189-98. PMID: 17031025.
      View in: PubMed
    34. Parker MA, Bell ML, Barlow LA. Cell contact-dependent mechanisms specify taste bud pattern during a critical period early in embryonic development. Dev Dyn. 2004 Aug; 230(4):630-42. PMID: 15254897.
      View in: PubMed
    35. Gross JB, Gottlieb AA, Barlow LA. Gustatory neurons derived from epibranchial placodes are attracted to, and trophically supported by, taste bud-bearing endoderm in vitro. Dev Biol. 2003 Dec 15; 264(2):467-81. PMID: 14651931.
      View in: PubMed
    36. Seta Y, Seta C, Barlow LA. Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions. J Comp Neurol. 2003 Sep 08; 464(1):49-61. PMID: 12866128.
      View in: PubMed
    37. Barlow LA. Toward a unified model of vertebrate taste bud development. J Comp Neurol. 2003 Mar 03; 457(2):107-10. PMID: 12541312.
      View in: PubMed
    38. Barlow LA. Cranial nerve development: placodal neurons ride the crest. Curr Biol. 2002 Mar 05; 12(5):R171-3. PMID: 11882306.
      View in: PubMed
    39. Barlow LA. Specification of pharyngeal endoderm is dependent on early signals from axial mesoderm. Development. 2001 Nov; 128(22):4573-83. PMID: 11714682.
      View in: PubMed
    40. Northcutt RG, Barlow LA, Braun CB, Catania KC. Distribution and innervation of taste buds in the axolotl. Brain Behav Evol. 2000 Sep; 56(3):123-45. PMID: 11124515.
      View in: PubMed
    41. Barlow LA. A taste for development. Neuron. 1999 Feb; 22(2):209-12. PMID: 10069326.
      View in: PubMed
    42. Barlow LA, Northcutt RG. The role of innervation in the development of taste buds: insights from studies of amphibian embryos. Ann N Y Acad Sci. 1998 Nov 30; 855:58-69. PMID: 9929586.
      View in: PubMed
    43. Northcutt RG, Barlow LA. Amphibians provide new insights into taste-bud development. Trends Neurosci. 1998 Jan; 21(1):38-43. PMID: 9464685.
      View in: PubMed
    44. Barlow LA, Northcutt RG. Taste buds develop autonomously from endoderm without induction by cephalic neural crest or paraxial mesoderm. Development. 1997 Mar; 124(5):949-57. PMID: 9056771.
      View in: PubMed
    45. Barlow LA, Chien CB, Northcutt RG. Embryonic taste buds develop in the absence of innervation. Development. 1996 Apr; 122(4):1103-11. PMID: 8620837.
      View in: PubMed
    46. Barlow LA, Northcutt RG. Embryonic origin of amphibian taste buds. Dev Biol. 1995 May; 169(1):273-85. PMID: 7750643.
      View in: PubMed
    47. Barlow LA, Northcutt RG. Analysis of the embryonic lineage of vertebrate taste buds. Chem Senses. 1994 Dec; 19(6):715-24. PMID: 7735849.
      View in: PubMed
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