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William J Janssen

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/398-1134

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mould KJ, Janssen WJ. Recombinant IFN-ß for Postseptic Acute Lung Injury-What's the Mechanism? Am J Respir Cell Mol Biol. 2018 Jul; 59(1):1-2. PMID: 29957050.
      View in: PubMed
    2. Ni K, Gill A, Tseng V, Mikosz AM, Koike K, Beatman EL, Xu CY, Cao D, Gally F, Mould KJ, Serban KA, Schweitzer KS, March KL, Janssen WJ, Nozik-Grayck E, Garantziotis S, Petrache I. Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury. Respir Res. 2018 May 31; 19(1):107. PMID: 29855321.
      View in: PubMed
    3. Ito Y, Al Mubarak R, Roberts N, Correll K, Janssen W, Finigan J, Mishra R, Chu HW. IL-13 induces periostin and eotaxin expression in human primary alveolar epithelial cells: Comparison with paired airway epithelial cells. PLoS One. 2018; 13(4):e0196256. PMID: 29672593.
      View in: PubMed
    4. Wesolowska-Andersen A, Everman JL, Davidson R, Rios C, Herrin R, Eng C, Janssen WJ, Liu AH, Oh SS, Kumar R, Fingerlin TE, Rodriguez-Santana J, Burchard EG, Seibold MA. Correction to: Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome. Genome Biol. 2018 04 10; 19(1):49. PMID: 29636099.
      View in: PubMed
    5. McCubbrey AL, Janssen WJ. Modulation of Myeloid Cell Function Using Conditional and Inducible Transgenic Approaches. Methods Mol Biol. 2018; 1809:145-168. PMID: 29987790.
      View in: PubMed
    6. Empey KM, Peebles RS, Janssen WJ. Mouse Models of Viral Infection. Methods Mol Biol. 2018; 1809:395-414. PMID: 29987803.
      View in: PubMed
    7. McCubbrey AL, Barthel L, Mohning MP, Redente EF, Mould KJ, Thomas SM, Leach SM, Danhorn T, Gibbings SL, Jakubzick CV, Henson PM, Janssen WJ. Deletion of c-FLIP from CD11bhi Macrophages Prevents Development of Bleomycin-induced Lung Fibrosis. Am J Respir Cell Mol Biol. 2018 01; 58(1):66-78. PMID: 28850249.
      View in: PubMed
    8. McCubbrey AL, Allison KC, Lee-Sherick AB, Jakubzick CV, Janssen WJ. Promoter Specificity and Efficacy in Conditional and Inducible Transgenic Targeting of Lung Macrophages. Front Immunol. 2017; 8:1618. PMID: 29225599.
      View in: PubMed
    9. Mohning MP, Thomas SM, Barthel L, Mould KJ, McCubbrey AL, Frasch SC, Bratton DL, Henson PM, Janssen WJ. Phagocytosis of microparticles by alveolar macrophages during acute lung injury requires MerTK. Am J Physiol Lung Cell Mol Physiol. 2018 01 01; 314(1):L69-L82. PMID: 28935638.
      View in: PubMed
    10. Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931657.
      View in: PubMed
    11. Mould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey AL, Danhorn T, Leach SM, Fingerlin TE, O'Connor BP, Reisz JA, D'Alessandro A, Bratton DL, Jakubzick CV, Janssen WJ. Cell Origin Dictates Programming of Resident versus Recruited Macrophages during Acute Lung Injury. Am J Respir Cell Mol Biol. 2017 09; 57(3):294-306. PMID: 28421818.
      View in: PubMed
    12. Gibbings SL, Thomas SM, Atif SM, McCubbrey AL, Desch AN, Danhorn T, Leach SM, Bratton DL, Henson PM, Janssen WJ, Jakubzick CV. Three Unique Interstitial Macrophages in the Murine Lung at Steady State. Am J Respir Cell Mol Biol. 2017 07; 57(1):66-76. PMID: 28257233.
      View in: PubMed
    13. Kumar R, Mickael C, Kassa B, Gebreab L, Robinson JC, Koyanagi DE, Sanders L, Barthel L, Meadows C, Fox D, Irwin D, Li M, McKeon BA, Riddle S, Dale Brown R, Morgan LE, Evans CM, Hernandez-Saavedra D, Bandeira A, Maloney JP, Bull TM, Janssen WJ, Stenmark KR, Tuder RM, Graham BB. TGF-ß activation by bone marrow-derived thrombospondin-1 causes Schistosoma- and hypoxia-induced pulmonary hypertension. Nat Commun. 2017 May 30; 8:15494. PMID: 28555642.
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    14. Pugliese SC, Kumar S, Janssen WJ, Graham BB, Frid MG, Riddle SR, El Kasmi KC, Stenmark KR. A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension. J Immunol. 2017 06 15; 198(12):4802-4812. PMID: 28500078.
      View in: PubMed
    15. Yunt ZX, Chung JH, Hobbs S, Fernandez-Perez ER, Olson AL, Huie TJ, Keith RC, Janssen WJ, Goldstein BL, Lynch DA, Brown KK, Swigris JJ, Solomon JJ. High resolution computed tomography pattern of usual interstitial pneumonia in rheumatoid arthritis-associated interstitial lung disease: Relationship to survival. Respir Med. 2017 05; 126:100-104. PMID: 28427540.
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    16. Janssen WJ, Nozik-Grayck E. Power of Place: Intravascular Superoxide Dismutase for Prevention of Acute Respiratory Distress Syndrome. Am J Respir Cell Mol Biol. 2017 02; 56(2):147-149. PMID: 28145771.
      View in: PubMed
    17. Wesolowska-Andersen A, Everman JL, Davidson R, Rios C, Herrin R, Eng C, Janssen WJ, Liu AH, Oh SS, Kumar R, Fingerlin TE, Rodriguez-Santana J, Burchard EG, Seibold MA. Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome. Genome Biol. 2017 01 19; 18(1):12. PMID: 28103897.
      View in: PubMed
    18. Murphy PS, Wang J, Bhagwat SP, Munger JC, Janssen WJ, Wright TW, Elliott MR. CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages. Cell Death Differ. 2017 03; 24(3):559-570. PMID: 28060378.
      View in: PubMed
    19. Mathai SK, Josephson SA, Badlam J, Saint S, Janssen WJ. Scratching Below the Surface. N Engl J Med. 2016 12 01; 375(22):2188-2193. PMID: 27959764.
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    20. Janssen WJ, Bratton DL, Jakubzick CV, Henson PM. Myeloid Cell Turnover and Clearance. Microbiol Spectr. 2016 11; 4(6). PMID: 27837740.
      View in: PubMed
    21. Janssen WJ, Stefanski AL, Bochner BS, Evans CM. Control of lung defence by mucins and macrophages: ancient defence mechanisms with modern functions. Eur Respir J. 2016 10; 48(4):1201-1214. PMID: 27587549.
      View in: PubMed
    22. McCubbrey AL, Barthel L, Mould KJ, Mohning MP, Redente EF, Janssen WJ. Selective and inducible targeting of CD11b+ mononuclear phagocytes in the murine lung with hCD68-rtTA transgenic systems. Am J Physiol Lung Cell Mol Physiol. 2016 07 01; 311(1):L87-L100. PMID: 27190063.
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    23. Desch AN, Gibbings SL, Goyal R, Kolde R, Bednarek J, Bruno T, Slansky JE, Jacobelli J, Mason R, Ito Y, Messier E, Randolph GJ, Prabagar M, Atif SM, Segura E, Xavier RJ, Bratton DL, Janssen WJ, Henson PM, Jakubzick CV. Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes. Am J Respir Crit Care Med. 2016 Mar 15; 193(6):614-26. PMID: 26551758; PMCID: PMC4824940 [Available on 03/15/17].
    24. Raclawska DS, Ttofali F, Fletcher AA, Harper DN, Bochner BS, Janssen WJ, Evans CM. Mucins and Their Sugars. Critical Mediators of Hyperreactivity and Inflammation. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S98-9. PMID: 27027967; PMCID: PMC5015746 [Available on 03/01/17].
    25. McCubbrey AL, Nelson JD, Stolberg VR, Blakely PK, McCloskey L, Janssen WJ, Freeman CM, Curtis JL. MicroRNA-34a Negatively Regulates Efferocytosis by Tissue Macrophages in Part via SIRT1. J Immunol. 2016 Feb 01; 196(3):1366-75. PMID: 26718338; PMCID: PMC4724467 [Available on 02/01/17].
    26. Kumar R, Mickael C, Chabon J, Gebreab L, Rutebemberwa A, Garcia AR, Koyanagi DE, Sanders L, Gandjeva A, Kearns MT, Barthel L, Janssen WJ, Mauad T, Bandeira A, Schmidt E, Tuder RM, Graham BB. The Causal Role of IL-4 and IL-13 in Schistosoma mansoni Pulmonary Hypertension. Am J Respir Crit Care Med. 2015 Oct 15; 192(8):998-1008. PMID: 26192556; PMCID: PMC4642207 [Available on 10/15/16].
    27. Gibbings SL, Goyal R, Desch AN, Leach SM, Prabagar M, Atif SM, Bratton DL, Janssen W, Jakubzick CV. Transcriptome analysis highlights the conserved difference between embryonic and postnatal-derived alveolar macrophages. Blood. 2015 Sep 10; 126(11):1357-66. PMID: 26232173; PMCID: PMC4566811.
    28. Ghosh M, Dwyer-Nield LD, Kwon JB, Barthel L, Janssen WJ, Merrick DT, Keith RL. Tracheal dysplasia precedes bronchial dysplasia in mouse model of N-nitroso trischloroethylurea induced squamous cell lung cancer. PLoS One. 2015; 10(4):e0122823. PMID: 25860262; PMCID: PMC4393296.
    29. Zemans RL, Henson PM, Henson JE, Janssen WJ. Conceptual approaches to lung injury and repair. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S9-15. PMID: 25830855; PMCID: PMC4430969.
    30. Mohning MP, Janssen WJ, Groshong SD, Canham EM. Anchored to asthma. Ann Am Thorac Soc. 2015 Mar; 12(3):448-50. PMID: 25786151.
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    31. Evans CM, Raclawska DS, Ttofali F, Liptzin DR, Fletcher AA, Harper DN, McGing MA, McElwee MM, Williams OW, Sanchez E, Roy MG, Kindrachuk KN, Wynn TA, Eltzschig HK, Blackburn MR, Tuvim MJ, Janssen WJ, Schwartz DA, Dickey BF. The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Nat Commun. 2015 Feb 17; 6:6281. PMID: 25687754; PMCID: PMC4333679.
    32. Kiwamoto T, Katoh T, Evans CM, Janssen WJ, Brummet ME, Hudson SA, Zhu Z, Tiemeyer M, Bochner BS. Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis. J Allergy Clin Immunol. 2015 May; 135(5):1329-1340.e9. PMID: 25497369.
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    33. Kedl RM, Wysocki LJ, Janssen WJ, Born WK, Rosenbaum MD, Granowski J, Kench JA, Fong DL, Switzer LA, Cruse M, Huang H, Jakubzick CV, Kosmider B, Takeda K, Stranova TJ, Klumm RC, Delgado C, Tummala S, De Langhe S, Cambier J, Haskins K, Lenz LL, Curran-Everett D. General parity between trio and pairwise breeding of laboratory mice in static caging. J Immunol. 2014 Nov 15; 193(10):4757-60. PMID: 25381356; PMCID: PMC4440340.
    34. Yunt ZX, Mohning MP, Barthel L, Kearns MT, Tuder RM, Hyde DM, Henson PM, Janssen WJ. Kinetics of the angiogenic response in lung endothelium following acute inflammatory injury with bleomycin. Exp Lung Res. 2014 Oct; 40(8):415-25. PMID: 25153689; PMCID: PMC4165791.
    35. Desch AN, Gibbings SL, Clambey ET, Janssen WJ, Slansky JE, Kedl RM, Henson PM, Jakubzick C. Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nat Commun. 2014 Aug 19; 5:4674. PMID: 25135627; PMCID: PMC4153365.
    36. Kearns MT, Barthel L, Bednarek JM, Yunt ZX, Henson PM, Janssen WJ. Fas ligand-expressing lymphocytes enhance alveolar macrophage apoptosis in the resolution of acute pulmonary inflammation. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 01; 307(1):L62-70. PMID: 24838751; PMCID: PMC4080285.
    37. Redente EF, Keith RC, Janssen W, Henson PM, Ortiz LA, Downey GP, Bratton DL, Riches DW. Tumor necrosis factor-a accelerates the resolution of established pulmonary fibrosis in mice by targeting profibrotic lung macrophages. Am J Respir Cell Mol Biol. 2014 Apr; 50(4):825-37. PMID: 24325577; PMCID: PMC4068926.
    38. Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP. Protein tyrosine phosphatase a mediates profibrotic signaling in lung fibroblasts through TGF-ß responsiveness. Am J Pathol. 2014 May; 184(5):1489-502. PMID: 24650563; PMCID: PMC4005983.
    39. Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Muc5b is required for airway defence. Nature. 2014 Jan 16; 505(7483):412-6. PMID: 24317696; PMCID: PMC4001806.
    40. Janssen WJ, Yunt ZX, Muldrow A, Kearns MT, Kloepfer A, Barthel L, Bratton DL, Bowler RP, Henson PM. Circulating hematopoietic progenitor cells are decreased in COPD. COPD. 2014 Jun; 11(3):277-89. PMID: 24182349; PMCID: PMC4112029.
    41. Janssen WJ. Alveolar macrophage dysfunction and chronic alcohol use. Time to think about zinc. Am J Respir Crit Care Med. 2013 Sep 15; 188(6):635-6. PMID: 24032380; PMCID: PMC3826189.
    42. Conwell WD, Josephson SA, Li H, Saint S, Janssen WJ. Clinical problem-solving. Weak in the knees. N Engl J Med. 2013 Aug 01; 369(5):459-64. PMID: 23902486.
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    43. Bhargava R, Janssen W, Altmann C, Andrés-Hernando A, Okamura K, Vandivier RW, Ahuja N, Faubel S. Intratracheal IL-6 protects against lung inflammation in direct, but not indirect, causes of acute lung injury in mice. PLoS One. 2013; 8(5):e61405. PMID: 23667439; PMCID: PMC3648558.
    44. Burnham EL, Janssen WJ, Riches DW, Moss M, Downey GP. The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J. 2014 Jan; 43(1):276-85. PMID: 23520315; PMCID: PMC4015132.
    45. Burnham EL, Hyzy RC, Paine R, Coley C, Kelly AM, Quint LE, Lynch D, Janssen WJ, Moss M, Standiford TJ. Chest CT features are associated with poorer quality of life in acute lung injury survivors. Crit Care Med. 2013 Feb; 41(2):445-56. PMID: 23263616; PMCID: PMC3671861.
    46. Lara AR, Cosgrove GP, Janssen WJ, Huie TJ, Burnham EL, Heinz DE, Curran-Everett D, Sahin H, Schwarz MI, Cool CD, Groshong SD, Geraci MW, Tuder RM, Hyde DM, Henson PM. Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia. Chest. 2012 Dec; 142(6):1569-1576. PMID: 22797508; PMCID: PMC3515029.
    47. Morimoto K, Janssen WJ, Terada M. Defective efferocytosis by alveolar macrophages in IPF patients. Respir Med. 2012 Dec; 106(12):1800-3. PMID: 22999220; PMCID: PMC4030720.
    48. Janssen WJ, Morimoto K. Apoptotic cell clearance and fibrotic lung disease. Eur Respir J. 2012 Aug; 40(2):289-90. PMID: 22855466; PMCID: PMC4036233.
    49. Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM. The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis. Nat Med. 2012 Aug; 18(8):1217-23. PMID: 22820644; PMCID: PMC3723751.
    50. Kosmider B, Messier EM, Janssen WJ, Nahreini P, Wang J, Hartshorn KL, Mason RJ. Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus. Respir Res. 2012 Jun 06; 13:43. PMID: 22672594; PMCID: PMC3520784.
    51. Finkelstein SE, Rodriguez F, Dunn M, Farmello MJ, Smilee R, Janssen W, Kang L, Chuang T, Seigne J, Pow-Sang J, Torres-Roca JF, Heysek R, Biagoli M, Shankar R, Scott J, Antonia S, Gabrilovich D, Fishman M. Serial assessment of lymphocytes and apoptosis in the prostate during coordinated intraprostatic dendritic cell injection and radiotherapy. Immunotherapy. 2012 Apr; 4(4):373-82. PMID: 22512631; PMCID: PMC4241355.
    52. Yang L, Isoda F, Yen K, Kleopoulos SP, Janssen W, Fan X, Mastaitis J, Dunn-Meynell A, Levin B, McCrimmon R, Sherwin R, Musatov S, Mobbs CV. Hypothalamic Fkbp51 is induced by fasting, and elevated hypothalamic expression promotes obese phenotypes. Am J Physiol Endocrinol Metab. 2012 Apr 15; 302(8):E987-91. PMID: 22318949; PMCID: PMC3330722.
    53. Kearns MT, Dalal S, Horstmann SA, Richens TR, Tanaka T, Doe JM, Boe DM, Voelkel NF, Taraseviciene-Stewart L, Janssen WJ, Lee CG, Elias JA, Bratton D, Tuder RM, Henson PM, Vandivier RW. Vascular endothelial growth factor enhances macrophage clearance of apoptotic cells. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 01; 302(7):L711-8. PMID: 22307908; PMCID: PMC3330764.
    54. Altmann C, Andres-Hernando A, McMahan RH, Ahuja N, He Z, Rivard CJ, Edelstein CL, Barthel L, Janssen WJ, Faubel S. Macrophages mediate lung inflammation in a mouse model of ischemic acute kidney injury. Am J Physiol Renal Physiol. 2012 Feb 15; 302(4):F421-32. PMID: 22114207; PMCID: PMC3289418.
    55. Janssen WJ, Henson PM. Cellular regulation of the inflammatory response. Toxicol Pathol. 2012; 40(2):166-73. PMID: 22089838; PMCID: PMC4138834.
    56. Janssen WJ, Barthel L, Muldrow A, Oberley-Deegan RE, Kearns MT, Jakubzick C, Henson PM. Fas determines differential fates of resident and recruited macrophages during resolution of acute lung injury. Am J Respir Crit Care Med. 2011 Sep 01; 184(5):547-60. PMID: 21471090; PMCID: PMC3175550.
    57. Fernandez-Boyanapalli R, McPhillips KA, Frasch SC, Janssen WJ, Dinauer MC, Riches DW, Henson PM, Byrne A, Bratton DL. Impaired phagocytosis of apoptotic cells by macrophages in chronic granulomatous disease is reversed by IFN-? in a nitric oxide-dependent manner. J Immunol. 2010 Oct 01; 185(7):4030-41. PMID: 20805415; PMCID: PMC4346245.
    58. Boé DM, Richens TR, Horstmann SA, Burnham EL, Janssen WJ, Henson PM, Moss M, Vandivier RW. Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response. Alcohol Clin Exp Res. 2010 Oct; 34(10):1723-32. PMID: 20608904; PMCID: PMC2950894.
    59. Huie TJ, Olson AL, Cosgrove GP, Janssen WJ, Lara AR, Lynch DA, Groshong SD, Moss M, Schwarz MI, Brown KK, Frankel SK. A detailed evaluation of acute respiratory decline in patients with fibrotic lung disease: aetiology and outcomes. Respirology. 2010 Aug; 15(6):909-17. PMID: 20546190.
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    60. Janssen WJ, Muldrow A, Kearns MT, Barthel L, Henson PM. Development and characterization of a lung-protective method of bone marrow transplantation in the mouse. J Immunol Methods. 2010 May 31; 357(1-2):1-9. PMID: 20347833.
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    61. Borges VM, Vandivier RW, McPhillips KA, Kench JA, Morimoto K, Groshong SD, Richens TR, Graham BB, Muldrow AM, Van Heule L, Henson PM, Janssen WJ. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L586-95. PMID: 19648283; PMCID: PMC2770785.
    62. Graham BB, Kaul DR, Saint S, Janssen WJ. Clinical problem-solving. Kiss of death. N Engl J Med. 2009 Jun 11; 360(24):2564-8. PMID: 19516037.
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    63. Lieu C, Janssen WJ, Saint S, Dhaliwal G. The tip of the iceberg. J Hosp Med. 2009 May; 4(5):317-20. PMID: 19504498.
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    64. Guth AM, Janssen WJ, Bosio CM, Crouch EC, Henson PM, Dow SW. Lung environment determines unique phenotype of alveolar macrophages. Am J Physiol Lung Cell Mol Physiol. 2009 Jun; 296(6):L936-46. PMID: 19304907; PMCID: PMC2692811.
    65. Richens TR, Linderman DJ, Horstmann SA, Lambert C, Xiao YQ, Keith RL, Boé DM, Morimoto K, Bowler RP, Day BJ, Janssen WJ, Henson PM, Vandivier RW. Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am J Respir Crit Care Med. 2009 Jun 01; 179(11):1011-21. PMID: 19264974; PMCID: PMC2689911.
    66. Graham BB, Burnham EL, Janssen JS, Janssen WJ. Dyspnea, chest pain, and altered mental status in a 33-year-old carpenter. Chest. 2008 Nov; 134(5):1074-1079. PMID: 18988783.
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    67. Gally F, Hartney JM, Janssen WJ, Perraud AL. CD38 plays a dual role in allergen-induced airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2009 Apr; 40(4):433-42. PMID: 18931329; PMCID: PMC2720120.
    68. Olson AL, Huie TJ, Groshong SD, Cosgrove GP, Janssen WJ, Schwarz MI, Brown KK, Frankel SK. Acute exacerbations of fibrotic hypersensitivity pneumonitis: a case series. Chest. 2008 Oct; 134(4):844-50. PMID: 18842917.
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    69. Janssen WJ, McPhillips KA, Dickinson MG, Linderman DJ, Morimoto K, Xiao YQ, Oldham KM, Vandivier RW, Henson PM, Gardai SJ. Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha. Am J Respir Crit Care Med. 2008 Jul 15; 178(2):158-67. PMID: 18420961; PMCID: PMC2453510.
    70. Dolgonos L, Janssen WJ. A 75-year-old woman with dyspnea and a sore throat. Chest. 2008 Apr; 133(4):1014-20. PMID: 18398123.
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    71. Linderman DJ, Janssen WJ. Critical care medicine for the hospitalist. Med Clin North Am. 2008 Mar; 92(2):467-79, x. PMID: 18298989.
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    72. Sareli AE, Janssen WJ, Sterman D, Saint S, Pyeritz RE. Clinical problem-solving. What's the connection? - A 26-year-old white man presented to our referral hospital with a 1-month history of persistent cough productive of white sputum, which was occasionally tinged with blood. N Engl J Med. 2008 Feb 07; 358(6):626-32. PMID: 18256398.
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    73. Ezzie ME, Janssen WJ, O'Brien JM, Fox CC, Schwarz MI. Clinical problem-solving. Failure to respond--a 52-year-old man presented to his primary care physician with dyspnea and cough. N Engl J Med. 2008 Jan 03; 358(1):70-4. PMID: 18172177.
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    74. McPhillips K, Janssen WJ, Ghosh M, Byrne A, Gardai S, Remigio L, Bratton DL, Kang JL, Henson P. TNF-alpha inhibits macrophage clearance of apoptotic cells via cytosolic phospholipase A2 and oxidant-dependent mechanisms. J Immunol. 2007 Jun 15; 178(12):8117-26. PMID: 17548650.
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    75. Robertson KB, Janssen WJ, Saint S, Weinberger SE. Clinical problem-solving. The missing piece. N Engl J Med. 2006 Nov 02; 355(18):1913-8. PMID: 17079766.
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    76. Jehle AW, Gardai SJ, Li S, Linsel-Nitschke P, Morimoto K, Janssen WJ, Vandivier RW, Wang N, Greenberg S, Dale BM, Qin C, Henson PM, Tall AR. ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J Cell Biol. 2006 Aug 14; 174(4):547-56. PMID: 16908670; PMCID: PMC2064260.
    77. Morimoto K, Janssen WJ, Fessler MB, Xiao YQ, McPhillips KA, Borges VM, Kench JA, Henson PM, Vandivier RW. Statins enhance clearance of apoptotic cells through modulation of Rho-GTPases. Proc Am Thorac Soc. 2006 Aug; 3(6):516-7. PMID: 16921133.
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    78. Morimoto K, Janssen WJ, Fessler MB, McPhillips KA, Borges VM, Bowler RP, Xiao YQ, Kench JA, Henson PM, Vandivier RW. Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease. J Immunol. 2006 Jun 15; 176(12):7657-65. PMID: 16751413.
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    79. Janssen WJ, Bierig LN, Beuther DA, Miller YE. Stridor in a 47-year-old man with inflammatory bowel disease. Chest. 2006 Apr; 129(4):1100-6. PMID: 16608963.
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    80. Xiao YQ, Freire-de-Lima CG, Janssen WJ, Morimoto K, Lyu D, Bratton DL, Henson PM. Oxidants selectively reverse TGF-beta suppression of proinflammatory mediator production. J Immunol. 2006 Jan 15; 176(2):1209-17. PMID: 16394011.
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    81. Janssen WJ, Collard HR, Saint S, Weinberger SE. Clinical problem-solving. A perfect storm. N Engl J Med. 2005 Nov 03; 353(18):1956-61. PMID: 16267327.
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