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Ellen L. Burnham

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-6078

    Collapse Biography 
    Collapse awards and honors
    2013Professional Leadership Award, University of Colorado
    2008Giles F. Filley Memorial Award in Respiratory Physiology and Medicine, American Physiological Society
    1995Alpha Omega Alpha Honor Society, University of Texas-Southwestern Medical School
    1991Phi Beta Kappa, Texas Christian University

    Collapse Overview 
    Collapse overview
    I am a pulmonary and critical care physician who also performs clinical and translational research. Our group's research focuses on the effect of alcohol and other drug consumption on the development of pneumonia and lung injury. Along with local and national collaborators, we have formed a consortium to enable translational investigations in this area, and have developed a biorepository to facilitate these investigations. Please see our consortium's website: CoPARC Other research interests of mine include junior faculty development, specifically, understanding and developing elements of the mentor-mentee relationship to promote career success. I am an Associate Program Director for the CCTSI's KL2 Mentored Career Development program that supports this role.
    Finally, I am the Medical Director of the University of Colorado's Medical ICU, where I am actively involved in multidisciplinary quality initiatives relevant to care of critically ill patients.

    Collapse Research 
    Collapse research activities and funding
    R01AA029855     (BURNHAM, ELLEN L)Sep 22, 2021 - Aug 31, 2024
    NIH
    Impact of Alcohol Misuse on Cognitive and Respiratory Outcomes in COVID-19-associated Acute Respiratory Failure
    Role: Principal Investigator
    R21AA028871     (BURNHAM, ELLEN L)Aug 20, 2021 - Jul 31, 2023
    NIH
    Impact of Dual Alcohol and Cannabis Use on Lung
    Role: Principal Investigator
    KL2TR002534     (BURNHAM, ELLEN L)May 1, 2018 - Apr 30, 2024
    NIH
    Institutional Career Development Core
    Role: Principal Investigator
    R24AA019661     (BURNHAM, ELLEN L)Aug 1, 2011 - Apr 30, 2024
    NIH
    CoPARC: Colorado Pulmonary Alcohol Research Collaborative
    Role: Principal Investigator
    K23AA013918     (BURNHAM, ELLEN L)Apr 1, 2003 - Dec 31, 2009
    NIH
    Alcohol, glutathione, and alveolar macrophage function
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mikacenic C, Fussner LA, Bell J, Burnham EL, Chlan LL, Cook SK, Dickson RP, Almonor F, Luo F, Madan K, Morales-Nebreda L, Mould KJ, Simpson AJ, Singer BD, Stapleton RD, Wendt CH, Files DC. Research Bronchoscopies in Critically Ill Research Participants: An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 2023 05; 20(5):621-631. PMID: 37125997.
      View in: PubMed
    2. Reynolds PM, Afshar M, Wright GC, Ho PM, Kiser TH, Sottile PD, Althoff MD, Moss M, Jolley SE, Vandivier RW, Burnham EL. Association between Substance Misuse and Outcomes in Critically III Patients with Pneumonia. Ann Am Thorac Soc. 2023 04; 20(4):556-565. PMID: 37000145.
      View in: PubMed
    3. Jolley SE, Mowry CJ, Erlandson KM, Wilson MP, Burnham EL. Impact of Alcohol Misuse on Requirements for Critical Care Services and Development of Hospital Delirium in Patients With COVID-19 pneumonia. Crit Care Explor. 2023 Jan; 5(1):e0829. PMID: 36713630.
      View in: PubMed
    4. Choy K, Dyamenahalli KU, Khair S, Colborn KL, Wiktor AJ, Idrovo JP, McMahan RH, Burnham EL, Kovacs EJ. Aberrant inflammatory responses in intoxicated burn-injured patients parallel impaired cognitive function. Alcohol. 2023 06; 109:35-41. PMID: 36690221.
      View in: PubMed
    5. Park BD, Kannappan A, Rizzo AN, Jin Y, Peterson RA, Burnham E, Moss M, Jolley S. Relationship Between a State-Directed Lockdown on Non-COVID-19-related ICU Admissions and Mortality in a Multicenter Colorado Healthcare System. Crit Care Explor. 2022 Dec; 4(12):e0791. PMID: 36506833.
      View in: PubMed
    6. Burns KEA, Moss M, Lorens E, Jose EKA, Martin CM, Viglianti EM, Fox-Robichaud A, Mathews KS, Akgun K, Jain S, Gershengorn H, Mehta S, Han JE, Martin GS, Liebler JM, Stapleton RD, Trachuk P, Vranas KC, Chua A, Herridge MS, Tsang JLY, Biehl M, Burnham EL, Chen JT, Attia EF, Mohamed A, Harkins MS, Soriano SM, Maddux A, West JC, Badke AR, Bagshaw SM, Binnie A, Carlos WG, ?oruh B, Crothers K, D'Aragon F, Denson JL, Drover JW, Eschun G, Geagea A, Griesdale D, Hadler R, Hancock J, Hasmatali J, Kaul B, Kerlin MP, Kohn R, Kutsogiannis DJ, Matson SM, Morris PE, Paunovic B, Peltan ID, Piquette D, Pirzadeh M, Pulchan K, Schnapp LM, Sessler CN, Smith H, Sy E, Thirugnanam S, McDonald RK, McPherson KA, Kraft M, Spiegel M, Dodek PM. Wellness and Coping of Physicians Who Worked in ICUs During the Pandemic: A Multicenter Cross-Sectional North American Survey. Crit Care Med. 2022 12 01; 50(12):1689-1700. PMID: 36300945.
      View in: PubMed
    7. Zakrajsek JK, Min SJ, Ho PM, Kiser TH, Kannappan A, Sottile PD, Allen RR, Althoff MD, Reynolds PM, Moss M, Burnham EL, Mikkelsen ME, Vandivier RW. Extracorporeal Membrane Oxygenation for Refractory Asthma Exacerbations With Respiratory Failure. Chest. 2023 01; 163(1):38-51. PMID: 36191634.
      View in: PubMed
    8. Dyamenahalli K, Choy K, Frank DN, Najarro K, Boe D, Colborn KL, Idrovo JP, Wagner AL, Wiktor AJ, Afshar M, Burnham EL, McMahan RH, Kovacs EJ. Age and Injury Size Influence the Magnitude of Fecal Dysbiosis in Adult Burn Patients. J Burn Care Res. 2022 09 01; 43(5):1145-1153. PMID: 35020913.
      View in: PubMed
    9. Kim E, Mathai SK, Stancil IT, Ma X, Hernandez-Gutierrez A, Becerra JN, Marrero-Torres E, Hennessy CE, Hatakka K, Wartchow EP, Estrella A, Huber JP, Cardwell JH, Burnham EL, Zhang Y, Evans CM, Vladar EK, Schwartz DA, Dobrinskikh E, Yang IV. Aberrant Multiciliogenesis in Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2022 08; 67(2):188-200. PMID: 35608953.
      View in: PubMed
    10. Chockalingam L, Burnham EL, Jolley SE. Medication prescribing for alcohol use disorders during alcohol-related encounters in a Colorado regional healthcare system. Alcohol Clin Exp Res. 2022 06; 46(6):1094-1102. PMID: 35723682.
      View in: PubMed
    11. Aschner Y, Correll KA, Beke KM, Foster DG, Roybal HM, Nelson MR, Meador CL, Strand M, Anderson KC, Moore CM, Reynolds PR, Kopf KW, Burnham EL, Downey GP. PTPa promotes fibroproliferative responses after acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2022 07 01; 323(1):L69-L83. PMID: 35670474.
      View in: PubMed
    12. Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, Khan KT, Koff JL, Lang J, LaRose M, Levitt J, Lu R, McKeehan JD, Meyer NJ, Russell DW, Thomas KW, Eklund M, Esserman LJ, Liu KD. I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations. BMJ Open. 2022 06 06; 12(6):e060664. PMID: 35667714.
      View in: PubMed
    13. Medepalli K, Purdon S, Bade RM, Glassberg MK, Burnham EL, Gershengorn HB. Association of Women Leaders with Women Program Director and Trainee Representation Across US Academic Internal Medicine. J Gen Intern Med. 2023 01; 38(1):57-66. PMID: 35604632.
      View in: PubMed
    14. Bailey KL, Sayles H, Campbell J, Khalid N, Anglim M, Ponce J, Wyatt TA, McClay JC, Burnham EL, Anzalone A, Hanson C. COVID-19 patients with documented alcohol use disorder or alcohol-related complications are more likely to be hospitalized and have higher all-cause mortality. Alcohol Clin Exp Res. 2022 06; 46(6):1023-1035. PMID: 35429004.
      View in: PubMed
    15. Sacha GL, Kiser TH, Wright GC, Vandivier RW, Moss M, Burnham EL, Ho PM, Reynolds PM, Bauer SR. Association Between Vasopressin Rebranding and Utilization in Patients With Septic Shock. Crit Care Med. 2022 04 01; 50(4):644-654. PMID: 34605778.
      View in: PubMed
    16. Liu C, Gaydos J, Johnson-Paben R, Kechris K, Burnham EL, Sharma S. Chronic Marijuana Use Is Associated with Gene Expression Changes in BAL. Am J Respir Cell Mol Biol. 2022 02; 66(2):238-239. PMID: 35103554.
      View in: PubMed
    17. Steel TL, Afshar M, Edwards S, Jolley SE, Timko C, Clark BJ, Douglas IS, Dzierba AL, Gershengorn HB, Gilpin NW, Godwin DW, Hough CL, Maldonado JR, Mehta AB, Nelson LS, Patel MB, Rastegar DA, Stollings JL, Tabakoff B, Tate JA, Wong A, Burnham EL. Research Needs for Inpatient Management of Severe Alcohol Withdrawal Syndrome: An Official American Thoracic Society Research Statement. Am J Respir Crit Care Med. 2021 10 01; 204(7):e61-e87. PMID: 34609257.
      View in: PubMed
    18. Neff S, Drake MG, Slatore CG, Burnham E. Inhaled Marijuana and the Lungs. Am J Respir Crit Care Med. 2021 09 01; 204(5):P9-P10. PMID: 34499025.
      View in: PubMed
    19. Wyatt TA, Warren KJ, Wetzel TJ, Suwondo T, Rensch GP, DeVasure JM, Mosley DD, Kharbanda KK, Thiele GM, Burnham EL, Bailey KL, Yeligar SM. Malondialdehyde-Acetaldehyde Adduct Formation Decreases Immunoglobulin A Transport across Airway Epithelium in Smokers Who Abuse Alcohol. Am J Pathol. 2021 10; 191(10):1732-1742. PMID: 34186073.
      View in: PubMed
    20. Tanabe J, Neff S, Sutton B, Ellis S, Patten L, Brown MS, Hoffman PL, Tabakoff B, Burnham EL. Effects of acetate on cerebral blood flow, systemic inflammation, and behavior in alcohol use disorder. Alcohol Clin Exp Res. 2021 05; 45(5):922-933. PMID: 33682145.
      View in: PubMed
    21. Afshar M, Baker K, Corral J, Ross E, Lowery E, Gonzalez R, Burnham EL, Callcut RA, Kornblith LZ, Hendrickson C, Kovacs EJ, Joyce C. Internal and External Validation of an Alcohol Biomarker for Screening in Trauma. Ann Surg. 2022 Dec 01; 276(6):e961-e968. PMID: 33534233.
      View in: PubMed
    22. Carmichael H, Wright FL, McIntyre RC, Vogler T, Urban S, Jolley SE, Burnham EL, Firth W, Velopulos CG, Idrovo JP. Early ventilator liberation and decreased sedation needs after tracheostomy in patients with COVID-19 infection. Trauma Surg Acute Care Open. 2021; 6(1):e000591. PMID: 34192162.
      View in: PubMed
    23. Althoff MD, Holguin F, Yang F, Grunwald GK, Moss M, Vandivier RW, Ho PM, Kiser TH, Burnham EL. Noninvasive Ventilation Use in Critically Ill Patients with Acute Asthma Exacerbations. Am J Respir Crit Care Med. 2020 12 01; 202(11):1520-1530. PMID: 32663410.
      View in: PubMed
    24. Bowden K, Burnham EL, Keniston A, Levin D, Limes J, Persoff J, Thurman L, Burden M. Harnessing the Power of Hospitalists in Operational Disaster Planning: COVID-19. J Gen Intern Med. 2020 09; 35(9):2732-2737. PMID: 32661930.
      View in: PubMed
    25. Bailey KL, Smith H, Mathai SK, Huber J, Yacoub M, Yang IV, Wyatt TA, Kechris K, Burnham EL. Alcohol Use Disorders Are Associated With a Unique Impact on Airway Epithelial Cell Gene Expression. Alcohol Clin Exp Res. 2020 08; 44(8):1571-1584. PMID: 32524622.
      View in: PubMed
    26. Hippensteel JA, Burnham EL, Jolley SE. Prevalence of venous thromboembolism in critically ill patients with COVID-19. Br J Haematol. 2020 08; 190(3):e134-e137. PMID: 32484907.
      View in: PubMed
    27. Hua JT, Afshar M, Clark BJ, Kovacs EJ, Burnham EL. The relationship of cannabis decriminalization in Colorado and cannabis use in individuals with alcohol use disorders. J Cannabis Res. 2020 Mar 02; 2(1):13. PMID: 33526125.
      View in: PubMed
    28. Afshar M, Burnham EL, Joyce C, Gagnon R, Dunn R, Albright JM, Ramirez L, Repine JE, Netzer G, Kovacs EJ. Injury Characteristics and von Willebrand Factor for the Prediction of Acute Respiratory Distress Syndrome in Patients With Burn Injury: Development and Internal Validation. Ann Surg. 2019 12; 270(6):1186-1193. PMID: 29697443.
      View in: PubMed
    29. Tanabe J, Yamamoto DJ, Sutton B, Brown MS, Hoffman PL, Burnham EL, Glueck DH, Tabakoff B. Effects of Alcohol and Acetate on Cerebral Blood Flow: A Pilot Study. Alcohol Clin Exp Res. 2019 10; 43(10):2070-2078. PMID: 31386214.
      View in: PubMed
    30. Burns KEA, Burnham EL, Dodek PM, Moss M. Unconscious bias in the selection and interpretation of data on sex and burnout - Authors' reply. Lancet Respir Med. 2019 08; 7(8):e24. PMID: 31342898.
      View in: PubMed
    31. Prohaska CC, Sottile PD, Nordon-Craft A, Gallagher MD, Burnham EL, Clark BJ, Ho M, Kiser TH, Vandivier RW, Liu W, Schenkman M, Moss M. Patterns of utilization and effects of hospital-specific factors on physical, occupational, and speech therapy for critically ill patients with acute respiratory failure in the USA: results of a 5-year sample. Crit Care. 2019 05 16; 23(1):175. PMID: 31097017.
      View in: PubMed
    32. Kiser TH, Reynolds PM, Moss M, Burnham EL, Ho PM, Vandivier RW. Impact of Macrolide Antibiotics on Hospital Readmissions and Other Clinically Important Outcomes in Critically Ill Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Propensity Score-Matched Cohort Study. Pharmacotherapy. 2019 03; 39(3):242-252. PMID: 30663791.
      View in: PubMed
    33. Burnham EL, Eakin MN, Pakhale S. Ethics of Health Research Supported by For-Profit Cannabis Companies: What Have We Learned from Big Tobacco? Ann Am Thorac Soc. 2019 03; 16(3):396-397. PMID: 30712358.
      View in: PubMed
    34. Burnham EL, Burns KEA, Moss M, Dodek PM. Burnout in women intensivists: a hidden epidemic? Lancet Respir Med. 2019 04; 7(4):292-294. PMID: 30744938.
      View in: PubMed
    35. Reynolds PM, Van Matre ET, Wright GC, McQueen RB, Burnham EL, Ho PJM, Moss M, Vandivier RW, Kiser TH. Evaluation of Prophylactic Heparin Dosage Strategies and Risk Factors for Venous Thromboembolism in the Critically Ill Patient. Pharmacotherapy. 2019 03; 39(3):232-241. PMID: 30592541.
      View in: PubMed
    36. Kiser TH, Burnham EL, Clark B, Ho PM, Allen RR, Moss M, Vandivier RW. The authors reply. Crit Care Med. 2018 12; 46(12):e1224-e1225. PMID: 30444823.
      View in: PubMed
    37. Van Matre ET, Reynolds PM, MacLaren R, Mueller SW, Wright GC, Moss M, Burnham EL, Ho PM, Vandivier RW, Kiser TH. Evaluation of unfractionated heparin versus low-molecular-weight heparin and fondaparinux for pharmacologic venous thromboembolic prophylaxis in critically ill patients with cancer. J Thromb Haemost. 2018 12; 16(12):2492-2500. PMID: 30347498.
      View in: PubMed
    38. Bailey KL, Wyatt TA, Katafiasz DM, Taylor KW, Heires AJ, Sisson JH, Romberger DJ, Burnham EL. Alcohol and cannabis use alter pulmonary innate immunity. Alcohol. 2019 11; 80:131-138. PMID: 30419300.
      View in: PubMed
    39. Kiser TH, Burnham EL, Clark B, Ho PM, Allen RR, Moss M, Vandivier RW. Half-Dose Versus Full-Dose Alteplase for Treatment of Pulmonary Embolism. Crit Care Med. 2018 10; 46(10):1617-1625. PMID: 29979222.
      View in: PubMed
    40. Gaydos J, McNally A, Burnham EL. The impact of alcohol use disorders on pulmonary immune cell inflammatory responses to Streptococcus pneumoniae. Alcohol. 2019 11; 80:119-130. PMID: 30195043.
      View in: PubMed
    41. Afshar M, Burnham EL, Joyce C, Kovacs EJ, Lowery EM. Optimal Cut-Points for Phosphatidylethanol Vary by Clinical Setting: Response to Nguyen and Seth's (2018) Letter to the Editor. Alcohol Clin Exp Res. 2018 10; 42(10):2064-2065. PMID: 30059162.
      View in: PubMed
    42. Breathett K, Liu WG, Allen LA, Daugherty SL, Blair IV, Jones J, Grunwald GK, Moss M, Kiser TH, Burnham E, Vandivier RW, Clark BJ, Lewis EF, Mazimba S, Battaglia C, Ho PM, Peterson PN. African Americans Are Less Likely to Receive Care by a Cardiologist During an?Intensive Care Unit Admission for Heart?Failure. JACC Heart Fail. 2018 05; 6(5):413-420. PMID: 29724363.
      View in: PubMed
    43. Sottile PD, Kiser TH, Burnham EL, Ho PM, Allen RR, Vandivier RW, Moss M. An Observational Study of the Efficacy of Cisatracurium Compared with Vecuronium in Patients with or at Risk for Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 04 01; 197(7):897-904. PMID: 29241014.
      View in: PubMed
    44. Kelmenson DA, Held N, Allen RR, Quan D, Burnham EL, Clark BJ, Ho PM, Kiser TH, Vandivier RW, Moss M. The authors reply. Crit Care Med. 2018 04; 46(4):e347-e348. PMID: 29538131.
      View in: PubMed
    45. Kelmenson DA, Held N, Allen RR, Quan D, Burnham EL, Clark BJ, Ho PM, Kiser TH, Vandivier RW, Moss M. Outcomes of ICU Patients With a Discharge Diagnosis of Critical Illness Polyneuromyopathy: A Propensity-Matched Analysis. Crit Care Med. 2017 Dec; 45(12):2055-2060. PMID: 29019851.
      View in: PubMed
    46. Sapkota M, Burnham EL, DeVasure JM, Sweeter JM, Hunter CD, Duryee MJ, Klassen LW, Kharbanda KK, Sisson JH, Thiele GM, Wyatt TA. Malondialdehyde-Acetaldehyde (MAA) Protein Adducts Are Found Exclusively in the Lungs of Smokers with Alcohol Use Disorders and Are Associated with Systemic Anti-MAA Antibodies. Alcohol Clin Exp Res. 2017 Dec; 41(12):2093-2099. PMID: 28941289.
      View in: PubMed
    47. Frankel JH, Boe DM, Albright JM, O'Halloran EB, Carter SR, Davis CS, Ramirez L, Burnham EL, Gamelli RL, Afshar M, Kovacs EJ. Age-related immune responses after burn and inhalation injury are associated with altered clinical outcomes. Exp Gerontol. 2018 05; 105:78-86. PMID: 29080833.
      View in: PubMed
    48. Neudecker V, Brodsky KS, Clambey ET, Schmidt EP, Packard TA, Davenport B, Standiford TJ, Weng T, Fletcher AA, Barthel L, Masterson JC, Furuta GT, Cai C, Blackburn MR, Ginde AA, Graner MW, Janssen WJ, Zemans RL, Evans CM, Burnham EL, Homann D, Moss M, Kreth S, Zacharowski K, Henson PM, Eltzschig HK. Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931657.
      View in: PubMed
    49. Afshar M, Burnham EL, Joyce C, Clark BJ, Yong M, Gaydos J, Cooper RS, Smith GS, Kovacs EJ, Lowery EM. Cut-Point Levels of Phosphatidylethanol to Identify Alcohol Misuse in a Mixed Cohort Including Critically Ill Patients. Alcohol Clin Exp Res. 2017 Oct; 41(10):1745-1753. PMID: 28792620.
      View in: PubMed
    50. Afshar M, Netzer G, Mosier MJ, Cooper RS, Adams W, Burnham EL, Kovacs EJ, Durazo-Arvizu R, Kliethermes S. The Contributing Risk of Tobacco Use for ARDS Development in Burn-Injured Adults With Inhalation Injury. Respir Care. 2017 Nov; 62(11):1456-1465. PMID: 28900039.
      View in: PubMed
    51. Samuelson DR, Burnham EL, Maffei VJ, Vandivier RW, Blanchard EE, Shellito JE, Luo M, Taylor CM, Welsh DA. The respiratory tract microbial biogeography in alcohol use disorder. Am J Physiol Lung Cell Mol Physiol. 2018 01 01; 314(1):L107-L117. PMID: 28860145.
      View in: PubMed
    52. Fini MA, Gaydos J, McNally A, Karoor V, Burnham EL. Alcohol abuse is associated with enhanced pulmonary and systemic xanthine oxidoreductase activity. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L1047-L1057. PMID: 28839105.
      View in: PubMed
    53. Nedumaran B, Rudra P, Gaydos J, Kumar S, Meacham RB, Burnham EL, Malykhina AP. Impact of Regular Cannabis Use on Biomarkers of Lower Urinary Tract Function. Urology. 2017 Nov; 109:223.e9-223.e16. PMID: 28827195.
      View in: PubMed
    54. Mehta S, Burns KEA, Machado FR, Fox-Robichaud AE, Cook DJ, Calfee CS, Ware LB, Burnham EL, Kissoon N, Marshall JC, Mancebo J, Finfer S, Hartog C, Reinhart K, Maitland K, Stapleton RD, Kwizera A, Amin P, Abroug F, Smith O, Laake JH, Shrestha GS, Herridge MS. Gender Parity in Critical Care Medicine. Am J Respir Crit Care Med. 2017 08 15; 196(4):425-429. PMID: 28240961.
      View in: PubMed
    55. Blumhagen RZ, Hedin BR, Malcolm KC, Burnham EL, Moss M, Abraham E, Huie TJ, Nick JA, Fingerlin TE, Alper S. Alternative pre-mRNA splicing of Toll-like receptor signaling components in peripheral blood mononuclear cells from patients with ARDS. Am J Physiol Lung Cell Mol Physiol. 2017 Nov 01; 313(5):L930-L939. PMID: 28775099.
      View in: PubMed
    56. Clark BJ, Jones J, Reed KD, Hodapp R, Douglas IS, Van Pelt D, Burnham EL, Moss M. The Experience of Patients with Alcohol Misuse after Surviving a Critical Illness. A Qualitative Study. Ann Am Thorac Soc. 2017 Jul; 14(7):1154-1161. PMID: 28406727.
      View in: PubMed
    57. Abdul-Muneer PM, Alikunju S, Mishra V, Schuetz H, Szlachetka AM, Burnham EL, Haorah J. Activation of NLRP3 inflammasome by cholesterol crystals in alcohol consumption induces atherosclerotic lesions. Brain Behav Immun. 2017 May; 62:291-305. PMID: 28232172.
      View in: PubMed
    58. Aschner Y, Burnham EL. Adjuvant Therapies for ARDS: Not Ready for Prime Time? Ann Am Thorac Soc. 2017 01; 14(1):14-16. PMID: 28035871.
      View in: PubMed
    59. Yeligar SM, Chen MM, Kovacs EJ, Sisson JH, Burnham EL, Brown LA. Alcohol and lung injury and immunity. Alcohol. 2016 09; 55:51-59. PMID: 27788778.
      View in: PubMed
    60. Burnham EL, McNally A, Gaydos J, Brown LA. The Relationship Between Airway Antioxidant Levels, Alcohol Use Disorders, and Cigarette Smoking. Alcohol Clin Exp Res. 2016 10; 40(10):2147-2160. PMID: 27627733.
      View in: PubMed
    61. Nick JA, Caceres SM, Kret JE, Poch KR, Strand M, Faino AV, Nichols DP, Saavedra MT, Taylor-Cousar JL, Geraci MW, Burnham EL, Fessler MB, Suratt BT, Abraham E, Moss M, Malcolm KC. Extremes of Interferon-Stimulated Gene Expression Associate with Worse Outcomes in the Acute Respiratory Distress Syndrome. PLoS One. 2016; 11(9):e0162490. PMID: 27606687.
      View in: PubMed
    62. Burnham EL, Roman J. Composition of the Sepsis Definitions Task Force. JAMA. 2016 Jul 26; 316(4):460-1. PMID: 27458965.
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    63. Cannon AR, Morris NL, Hammer AM, Curtis B, Remick DG, Yeligar SM, Poole L, Burnham EL, Wyatt TA, Molina PE, So-Armah K, Cisneros T, Wang G, Lang CH, Mandrekar P, Kovacs EJ, Choudhry MA. Alcohol and inflammatory responses: Highlights of the 2015 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol. 2016 08; 54:73-7. PMID: 27522326.
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    64. Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS. Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Thorax. 2016 12; 71(12):1130-1136. PMID: 26839359.
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    65. Gaydos J, McNally A, Guo R, Vandivier RW, Simonian PL, Burnham EL. Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15; 310(6):L507-18. PMID: 26747782.
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    66. Afshar M, Foster CL, Layden JE, Burnham EL. Azithromycin use and outcomes in severe sepsis patients with and without pneumonia. J Crit Care. 2016 Apr; 32:120-5. PMID: 26803186.
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    67. O'Halloran EB, Curtis BJ, Afshar M, Chen MM, Kovacs EJ, Burnham EL. Alveolar macrophage inflammatory mediator expression is elevated in the setting of alcohol use disorders. Alcohol. 2016 Feb; 50:43-50. PMID: 26781212.
      View in: PubMed
    68. Wehrmann F, Lavelle JC, Collins CB, Tinega AN, Thurman JM, Burnham EL, Simonian PL. ?d T cells protect against LPS-induced lung injury. J Leukoc Biol. 2016 Feb; 99(2):373-86. PMID: 26428678.
      View in: PubMed
    69. Biehl JR, Burnham EL. Cannabis Smoking in 2015: A Concern for Lung Health? Chest. 2015 Sep; 148(3):596-606. PMID: 25996274.
      View in: PubMed
    70. Bailey KL, Romberger DJ, Katafiasz DM, Heires AJ, Sisson JH, Wyatt TA, Burnham EL. TLR2 and TLR4 Expression and Inflammatory Cytokines are Altered in the Airway Epithelium of Those with Alcohol Use Disorders. Alcohol Clin Exp Res. 2015 Sep; 39(9):1691-7. PMID: 26208141.
      View in: PubMed
    71. Obianyo O, Liang Y, Burnham EL, Mehta A, Park Y, Uppal K, Harris FL, Jones DP, Brown LA. Metabolic Consequences of Chronic Alcohol Abuse in Non-Smokers: A Pilot Study. PLoS One. 2015; 10(6):e0129570. PMID: 26102199.
      View in: PubMed
    72. Riches DW, Burnham EL, Moss M, Downey GP, Schmidt EP. Introduction to the 57th annual Thomas L. Petty Aspen Lung Conference: Rebuilding the injured lung. Ann Am Thorac Soc. 2015 Mar; 12 Suppl 1:S1-2. PMID: 25830827.
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    73. Burnham EL, Hyzy RC, Paine R, Kelly AM, Quint LE, Lynch D, Curran-Everett D, Moss M, Standiford TJ. Detection of fibroproliferation by chest high-resolution CT scan in resolving ARDS. Chest. 2014 Nov; 146(5):1196-1204. PMID: 24722949.
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    74. Pfund C, House SC, Asquith P, Fleming MF, Buhr KA, Burnham EL, Eichenberger Gilmore JM, Huskins WC, McGee R, Schurr K, Shapiro ED, Spencer KC, Sorkness CA. Training mentors of clinical and translational research scholars: a randomized controlled trial. Acad Med. 2014 May; 89(5):774-82. PMID: 24667509.
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    75. Tanaka T, Doe JM, Horstmann SA, Ahmad S, Ahmad A, Min SJ, Reynolds PR, Suram S, Gaydos J, Burnham EL, Vandivier RW. Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells. J Biol Chem. 2014 Apr 11; 289(15):10466-10475. PMID: 24570000.
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    76. Burnham EL. 24/7 attendings: "helicoptering" the housestaff? Pediatrics. 2014 Jan; 133(1):131-3. PMID: 24323999.
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    77. Smart A, Thompson BT, Needham DM, Hopkins RO, Williams A, Burnham EL, Moss M. Surrogate consent for genetic testing, the reconsent process, and consent for long-term outcomes in acute respiratory distress syndrome trials. Am J Respir Crit Care Med. 2013 Dec 01; 188(11):1370-3. PMID: 24289781.
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    78. Macht M, King CJ, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Post-extubation dysphagia is associated with longer hospitalization in survivors of critical illness with neurologic impairment. Crit Care. 2013 Jun 20; 17(3):R119. PMID: 23786755.
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    79. Clark BJ, Williams A, Feemster LM, Bradley KA, Macht M, Moss M, Burnham EL. Alcohol screening scores and 90-day outcomes in patients with acute lung injury. Crit Care Med. 2013 Jun; 41(6):1518-25. PMID: 23538449.
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    80. Clark BJ, Bull TM, Benson AB, Stream AR, Macht M, Gaydos J, Meadows C, Burnham EL, Moss M. Growth differentiation factor-15 and prognosis in acute respiratory distress syndrome: a retrospective cohort study. Crit Care. 2013 May 24; 17(3):R92. PMID: 23706007.
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    81. Clark BJ, Keniston A, Douglas IS, Beresford T, Macht M, Williams A, Jones J, Burnham EL, Moss M. Healthcare utilization in medical intensive care unit survivors with alcohol withdrawal. Alcohol Clin Exp Res. 2013 Sep; 37(9):1536-43. PMID: 23647435.
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    82. Burnham EL, Kovacs EJ, Davis CS. Pulmonary cytokine composition differs in the setting of alcohol use disorders and cigarette smoking. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15; 304(12):L873-82. PMID: 23605000.
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    83. Burnham EL, Janssen WJ, Riches DW, Moss M, Downey GP. The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance. Eur Respir J. 2014 Jan; 43(1):276-85. PMID: 23520315.
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    84. Burnham EL, Hyzy RC, Paine R, Coley C, Kelly AM, Quint LE, Lynch D, Janssen WJ, Moss M, Standiford TJ. Chest CT features are associated with poorer quality of life in acute lung injury survivors. Crit Care Med. 2013 Feb; 41(2):445-56. PMID: 23263616.
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    85. Lara AR, Cosgrove GP, Janssen WJ, Huie TJ, Burnham EL, Heinz DE, Curran-Everett D, Sahin H, Schwarz MI, Cool CD, Groshong SD, Geraci MW, Tuder RM, Hyde DM, Henson PM. Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia. Chest. 2012 Dec; 142(6):1569-1576. PMID: 22797508.
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    86. Fleming M, Burnham EL, Huskins WC. Mentoring translational science investigators. JAMA. 2012 Nov 21; 308(19):1981-2. PMID: 23168821.
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    87. Macht M, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Diagnosis and treatment of post-extubation dysphagia: results from a national survey. J Crit Care. 2012 Dec; 27(6):578-86. PMID: 23084136.
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    88. Finigan JH, Mishra R, Vasu VT, Silveira LJ, Nethery DE, Standiford TJ, Burnham EL, Moss M, Kern JA. Bronchoalveolar lavage neuregulin-1 is elevated in acute lung injury and correlates with inflammation. Eur Respir J. 2013 Feb; 41(2):396-401. PMID: 22599357.
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    89. Albright JM, Davis CS, Bird MD, Ramirez L, Kim H, Burnham EL, Gamelli RL, Kovacs EJ. The acute pulmonary inflammatory response to the graded severity of smoke inhalation injury. Crit Care Med. 2012 Apr; 40(4):1113-21. PMID: 22067627.
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    90. Burnham EL, McCord JM, Bose S, Brown LA, House R, Moss M, Gaydos J. Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 01; 302(7):L688-99. PMID: 22268125.
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    91. Paine R, Standiford TJ, Dechert RE, Moss M, Martin GS, Rosenberg AL, Thannickal VJ, Burnham EL, Brown MB, Hyzy RC. A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury. Crit Care Med. 2012 Jan; 40(1):90-7. PMID: 21926600.
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    92. Baker TA, Davis CS, Bach HH, Romero J, Burnham EL, Kovacs EJ, Gamelli RL, Majetschak M. Ubiquitin and stromal cell-derived factor-1a in bronchoalveolar lavage fluid after burn and inhalation injury. J Burn Care Res. 2012 Jan-Feb; 33(1):57-64. PMID: 22105097.
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    93. Fisichella PM, Davis CS, Lundberg PW, Lowery E, Burnham EL, Alex CG, Ramirez L, Pelletiere K, Love RB, Kuo PC, Kovacs EJ. The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation. Surgery. 2011 Oct; 150(4):598-606. PMID: 22000170.
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    94. Macht M, Wimbish T, Clark BJ, Benson AB, Burnham EL, Williams A, Moss M. Postextubation dysphagia is persistent and associated with poor outcomes in survivors of critical illness. Crit Care. 2011; 15(5):R231. PMID: 21958475.
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    95. Clark BJ, Smart A, House R, Douglas I, Burnham EL, Moss M. Severity of acute illness is associated with baseline readiness to change in medical intensive care unit patients with unhealthy alcohol use. Alcohol Clin Exp Res. 2012 Mar; 36(3):544-51. PMID: 21950704.
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    96. Malcolm KC, Kret JE, Young RL, Poch KR, Caceres SM, Douglas IS, Coldren CD, Burnham EL, Moss M, Nick JA. Bacteria-specific neutrophil dysfunction associated with interferon-stimulated gene expression in the acute respiratory distress syndrome. PLoS One. 2011; 6(7):e21958. PMID: 21755013.
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    97. Burnham EL, Schiro S, Fleming M. Mentoring K scholars: strategies to support research mentors. Clin Transl Sci. 2011 Jun; 4(3):199-203. PMID: 21707951.
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    98. Majka S, Burnham E, Stenmark KR. Cell-based therapies in pulmonary hypertension: who, what, and when? Am J Physiol Lung Cell Mol Physiol. 2011 Jul; 301(1):L9-L11. PMID: 21515661.
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    99. Burnham EL, Fleming M. Selection of research mentors for K-funded scholars. Clin Transl Sci. 2011 Apr; 4(2):87-92. PMID: 21463493.
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    100. Burnham EL, Phang TL, House R, Vandivier RW, Moss M, Gaydos J. Alveolar macrophage gene expression is altered in the setting of alcohol use disorders. Alcohol Clin Exp Res. 2011 Feb; 35(2):284-94. PMID: 21121937.
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    101. Burnham EL, Gaydos J, Hess E, House R, Cooper J. Alcohol use disorders affect antimicrobial proteins and anti-pneumococcal activity in epithelial lining fluid obtained via bronchoalveolar lavage. Alcohol Alcohol. 2010 Sep-Oct; 45(5):414-21. PMID: 20729531.
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    102. Bo? DM, Richens TR, Horstmann SA, Burnham EL, Janssen WJ, Henson PM, Moss M, Vandivier RW. Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response. Alcohol Clin Exp Res. 2010 Oct; 34(10):1723-32. PMID: 20608904.
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    103. Burnham EL, Moss M, Geraci MW. The case for 24/7 in-house intensivist coverage. Am J Respir Crit Care Med. 2010 Jun 01; 181(11):1159-60. PMID: 20516489.
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    104. Burnham EL, Mealer M, Gaydos J, Majka S, Moss M. Acute lung injury but not sepsis is associated with increased colony formation by peripheral blood mononuclear cells. Am J Respir Cell Mol Biol. 2010 Sep; 43(3):326-33. PMID: 19843706.
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    105. Bo? DM, Vandivier RW, Burnham EL, Moss M. Alcohol abuse and pulmonary disease. J Leukoc Biol. 2009 Nov; 86(5):1097-104. PMID: 19602670.
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    106. Mealer M, Burnham EL, Goode CJ, Rothbaum B, Moss M. The prevalence and impact of post traumatic stress disorder and burnout syndrome in nurses. Depress Anxiety. 2009; 26(12):1118-26. PMID: 19918928.
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    107. Graham BB, Burnham EL, Janssen JS, Janssen WJ. Dyspnea, chest pain, and altered mental status in a 33-year-old carpenter. Chest. 2008 Nov; 134(5):1074-1079. PMID: 18988783.
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    108. Majka SM, Skokan M, Wheeler L, Harral J, Gladson S, Burnham E, Loyd JE, Stenmark KR, Varella-Garcia M, West J. Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Dec; 295(6):L1028-39. PMID: 18931051.
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    109. de Wit M, Gennings C, Zilberberg M, Burnham EL, Moss M, Balster RL. Drug withdrawal, cocaine and sedative use disorders increase the need for mechanical ventilation in medical patients. Addiction. 2008 Sep; 103(9):1500-8. PMID: 18636996.
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    110. Burnham EL. Identification of risky alcohol consumption in the preoperative assessment: opportunity to diagnose and intervene. Anesthesiology. 2008 Aug; 109(2):169-70. PMID: 18648224.
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    111. Burnham EL, Halkar R, Burks M, Moss M. The effects of alcohol abuse on pulmonary alveolar-capillary barrier function in humans. Alcohol Alcohol. 2009 Jan-Feb; 44(1):8-12. PMID: 18567916.
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    112. Burnham EL. Circulating progenitors in lung injury: a novel therapy for acute respiratory distress syndrome? Anesthesiology. 2008 Mar; 108(3):354-6. PMID: 18292671.
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    113. Martin J, Helm K, Ruegg P, Varella-Garcia M, Burnham E, Majka S. Adult lung side population cells have mesenchymal stem cell potential. Cytotherapy. 2008; 10(2):140-51. PMID: 18368593.
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    114. Yeh MY, Burnham EL, Moss M, Brown LA. Non-invasive evaluation of pulmonary glutathione in the exhaled breath condensate of otherwise healthy alcoholics. Respir Med. 2008 Feb; 102(2):248-55. PMID: 17977706.
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    115. de Wit M, Best AM, Gennings C, Burnham EL, Moss M. Alcohol use disorders increase the risk for mechanical ventilation in medical patients. Alcohol Clin Exp Res. 2007 Jul; 31(7):1224-30. PMID: 17511746.
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    116. Yeh MY, Burnham EL, Moss M, Brown LA. Chronic alcoholism alters systemic and pulmonary glutathione redox status. Am J Respir Crit Care Med. 2007 Aug 01; 176(3):270-6. PMID: 17507544.
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    117. Burnham EL, Moss M, Ritzenthaler JD, Roman J. Increased fibronectin expression in lung in the setting of chronic alcohol abuse. Alcohol Clin Exp Res. 2007 Apr; 31(4):675-83. PMID: 17374047.
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    118. Moss M, Burnham EL. Alcohol abuse in the critically ill patient. Lancet. 2006 Dec 23; 368(9554):2231-42. PMID: 17189035.
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    119. Burnham E, Moss M. Progenitor cells in acute lung injury. Minerva Anestesiol. 2006 Jun; 72(6):369-74. PMID: 16682903.
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    120. Khan J, Burnham EL, Moss M. Acquired weakness in the ICU: critical illness myopathy and polyneuropathy. Minerva Anestesiol. 2006 Jun; 72(6):401-6. PMID: 16682908.
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    121. Esper A, Burnham EL, Moss M. The effect of alcohol abuse on ARDS and multiple organ dysfunction. Minerva Anestesiol. 2006 Jun; 72(6):375-81. PMID: 16682904.
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    122. Burnham EL, Moss M, Ziegler TR. Myopathies in critical illness: characterization and nutritional aspects. J Nutr. 2005 Jul; 135(7):1818S-1823S. PMID: 15987872.
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    123. Burnham EL, Taylor WR, Quyyumi AA, Rojas M, Brigham KL, Moss M. Increased circulating endothelial progenitor cells are associated with survival in acute lung injury. Am J Respir Crit Care Med. 2005 Oct 01; 172(7):854-60. PMID: 15976374.
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    124. Burnham EL, Moss M, Harris F, Brown LA. Elevated plasma and lung endothelial selectin levels in patients with acute respiratory distress syndrome and a history of chronic alcohol abuse. Crit Care Med. 2004 Mar; 32(3):675-9. PMID: 15090946.
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    125. Burnham EL, Brown LA, Halls L, Moss M. Effects of chronic alcohol abuse on alveolar epithelial barrier function and glutathione homeostasis. Alcohol Clin Exp Res. 2003 Jul; 27(7):1167-72. PMID: 12878924.
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    126. Moss M, Burnham EL. Chronic alcohol abuse, acute respiratory distress syndrome, and multiple organ dysfunction. Crit Care Med. 2003 Apr; 31(4 Suppl):S207-12. PMID: 12682442.
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    127. Moss M, Parsons PE, Steinberg KP, Hudson LD, Guidot DM, Burnham EL, Eaton S, Cotsonis GA. Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock. Crit Care Med. 2003 Mar; 31(3):869-77. PMID: 12626999.
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    128. Schortgen F, Brochard L, Burnham E, Martin GS. Pro/con clinical debate: Hydroxyethylstarches should be avoided in septic patients. Crit Care. 2003 Aug; 7(4):279-81. PMID: 12930549.
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