Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Roy Robert Parker

TitleDistinguished Professor
InstitutionUniversity of Colorado Boulder
DepartmentBiochemistry
    Other Positions
    TitleDistinguished Professor
    InstitutionUniversity of Colorado Boulder
    DepartmentBiology-MCD Instruction


    Collapse Research 
    Collapse research activities and funding
    R13CA106607     (PARKER, ROY R)Jul 15, 2004 - Jul 14, 2005
    NIH
    Post-transcriptional control of gene expression
    Role: Principal Investigator
    T32GM008659     (CAPALDI, ANDREW PAUL)Jul 1, 1997 - Jun 30, 2020
    NIH
    Graduate Training in Biochemistry and Molecular Biology
    Role: Co-Principal Investigator
    R13GM056330     (PARKER, ROY R)Jun 22, 1997 - Jun 27, 1997
    NIH
    1997 GORDON CONFERENCE ON NUCLEIC ACIDS
    Role: Principal Investigator
    R01GM045443     (PARKER, ROY)Apr 1, 1991 - Mar 31, 2022
    NIH
    Stress Granules in Yeast and Mammals
    Role: Principal Investigator
    R37GM045443     (PARKER, ROY)Apr 1, 1991 - Mar 31, 2014
    NIH
    mRNA Decapping in Yeast
    Role: Principal Investigator
    F32GM011479     (PARKER, ROY R)Dec 17, 1986
    NIH
    LOCALIZATION OF NUCLEAR MEMBRANE PROTEINS IN YEAST
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Khong A, Ripin N, de Vasconcelos LM, Passanisi V, Spencer S, Parker R. Stress granules promote quiescence by enhancing p21 levels and reducing phospho-Rb. RNA. 2025 Sep 16; 31(10):1472-1487. PMID: 40738736.
      View in: PubMed
    2. Van Alstyne M, Brown G, Nguyen VL, Ramaswami M, Hoeffer CA, Parker R. Polyserine-mediated targeting of FAF2/UBXD8 ameliorates tau aggregation. Neuron. 2025 Aug 29. PMID: 40902597.
      View in: PubMed
    3. Pratt J, McCann K, Kuo J, Parker R. Polyserine-tau interactions modulate tau fibrillization. J Biol Chem. 2025 Sep; 301(9):110523. PMID: 40716749.
      View in: PubMed
    4. Smith MH, Parker RR, Patrick KL, Courvan EMC. Plans within plans: post-transcriptional regulation governs macrophage responses. Trends Immunol. 2025 Aug; 46(8):573-585. PMID: 40592687.
      View in: PubMed
    5. Van Alstyne M, Pratt J, Parker R. Diverse influences on tau aggregation and implications for disease progression. Genes Dev. 2025 May 02; 39(9-10):555-581. PMID: 40113250.
      View in: PubMed
    6. Ouyang JPT, Shukla S, Bensalah M, Parker R. DM1 repeat-expanded RNAs confer RNA toxicity as individual nuclear-retained RNAs. Cell Rep. 2025 May 27; 44(5):115582. PMID: 40238630.
      View in: PubMed
    7. Courvan EMC, Parker RR. Regulation of Cajal bodies: Unexpected connection to 60S ribosomes. J Cell Biol. 2025 Feb 03; 224(2). PMID: 39786343.
      View in: PubMed
    8. Parker DM, Tauber D, Parker R. G3BP1 promotes intermolecular RNA-RNA interactions during RNA condensation. Mol Cell. 2025 Feb 06; 85(3):571-584.e7. PMID: 39637853.
      View in: PubMed
    9. Courvan EMC, Parker RR. Hypoxia and inflammation induce synergistic transcriptome turnover in macrophages. Cell Rep. 2024 07 23; 43(7):114452. PMID: 38968068.
      View in: PubMed
    10. Parker DM, Bublitz GR, Parker R. Shining light on DHX9: UV-induced stress granules illuminate protective mechanisms for daughter cell resilience. Mol Cell. 2024 Apr 18; 84(8):1403-1405. PMID: 38640893.
      View in: PubMed
    11. Shehata SI, Watkins JM, Burke JM, Parker R. Mechanisms and consequences of mRNA destabilization during viral infections. Virol J. 2024 02 06; 21(1):38. PMID: 38321453.
      View in: PubMed
    12. Ripin N, Parker R. Formation, function, and pathology of RNP granules. Cell. 2023 10 26; 186(22):4737-4756. PMID: 37890457.
      View in: PubMed
    13. Huynh TN, Parker R. The PARN, TOE1, and USB1 RNA deadenylases and their roles in non-coding RNA regulation. J Biol Chem. 2023 09; 299(9):105139. PMID: 37544646.
      View in: PubMed
    14. Huynh TN, Shukla S, Reigan P, Parker R. Identification of PARN nuclease activity inhibitors by computational-based docking and high-throughput screening. Sci Rep. 2023 03 31; 13(1):5244. PMID: 37002320.
      View in: PubMed
    15. Batista LFZ, Dokal I, Parker R. Telomere biology disorders: time for moving towards the clinic? Trends Mol Med. 2022 10; 28(10):882-891. PMID: 36057525.
      View in: PubMed
    16. Khong A, Matheny T, Huynh TN, Babl V, Parker R. Limited effects of m6A modification on mRNA partitioning into stress granules. Nat Commun. 2022 06 29; 13(1):3735. PMID: 35768440.
      View in: PubMed
    17. Pratt J, Lester E, Parker R. Could SARS-CoV-2 cause tauopathy? Lancet Neurol. 2021 07; 20(7):506. PMID: 34146504.
      View in: PubMed
    18. Larremore DB, Toomre D, Parker R. Modeling the effectiveness of olfactory testing to limit SARS-CoV-2 transmission. Nat Commun. 2021 06 16; 12(1):3664. PMID: 34135322.
      View in: PubMed
    19. Burke JM, Gilchrist AR, Sawyer SL, Parker R. RNase L limits host and viral protein synthesis via inhibition of mRNA export. Sci Adv. 2021 06; 7(23). PMID: 34088676.
      View in: PubMed
    20. Yang Q, Saldi TK, Gonzales PK, Lasda E, Decker CJ, Tat KL, Fink MR, Hager CR, Davis JC, Ozeroff CD, Muhlrad D, Clark SK, Fattor WT, Meyerson NR, Paige CL, Gilchrist AR, Barbachano-Guerrero A, Worden-Sapper ER, Wu SS, Brisson GR, McQueen MB, Dowell RD, Leinwand L, Parker R, Sawyer SL. Just 2% of SARS-CoV-2-positive individuals carry 90% of the virus circulating in communities. Proc Natl Acad Sci U S A. 2021 05 25; 118(21). PMID: 33972412.
      View in: PubMed
    21. Lester E, Ooi FK, Bakkar N, Ayers J, Woerman AL, Wheeler J, Bowser R, Carlson GA, Prusiner SB, Parker R. Tau aggregates are RNA-protein assemblies that mislocalize multiple nuclear speckle components. Neuron. 2021 05 19; 109(10):1675-1691.e9. PMID: 33848474.
      View in: PubMed
    22. Larremore DB, Wilder B, Lester E, Shehata S, Burke JM, Hay JA, Tambe M, Mina MJ, Parker R. Test sensitivity is secondary to frequency and turnaround time for COVID-19 screening. Sci Adv. 2021 01; 7(1). PMID: 33219112.
      View in: PubMed
    23. Weskamp K, Olwin BB, Parker R. Post-Transcriptional Regulation in Skeletal Muscle Development, Repair, and Disease. Trends Mol Med. 2021 05; 27(5):469-481. PMID: 33384234.
      View in: PubMed
    24. Hoon-Hanks LL, St?hr AC, Anderson AJ, Evans DE, Nevarez JG, D?az RE, Rodgers CP, Cross ST, Steiner HR, Parker RR, Stenglein MD. Serpentovirus (Nidovirus) and Orthoreovirus Coinfection in Captive Veiled Chameleons (Chamaeleo calyptratus) with Respiratory Disease. Viruses. 2020 11 19; 12(11). PMID: 33228135.
      View in: PubMed
    25. Tauber D, Tauber G, Parker R. Mechanisms and Regulation of RNA Condensation in RNP Granule Formation. Trends Biochem Sci. 2020 09; 45(9):764-778. PMID: 32475683.
      View in: PubMed
    26. Tauber D, Tauber G, Khong A, Van Treeck B, Pelletier J, Parker R. Modulation of RNA Condensation by the DEAD-Box Protein eIF4A. Cell. 2020 02 06; 180(3):411-426.e16. PMID: 31928844.
      View in: PubMed
    27. Matheny T, Rao BS, Parker R. Transcriptome-Wide Comparison of Stress Granules and P-Bodies Reveals that Translation Plays a Major Role in RNA Partitioning. Mol Cell Biol. 2019 12 15; 39(24). PMID: 31591142.
      View in: PubMed
    28. Decker CJ, Steiner HR, Hoon-Hanks LL, Morrison JH, Haist KC, Stabell AC, Poeschla EM, Morrison TE, Stenglein MD, Sawyer SL, Parker R. dsRNA-Seq: Identification of Viral Infection by Purifying and Sequencing dsRNA. Viruses. 2019 10 14; 11(10). PMID: 31615058.
      View in: PubMed
    29. Burke JM, Moon SL, Matheny T, Parker R. RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs. Mol Cell. 2019 09 19; 75(6):1203-1217.e5. PMID: 31494035.
      View in: PubMed
    30. Shukla S, Bjerke GA, Muhlrad D, Yi R, Parker R. The RNase PARN Controls the Levels of Specific miRNAs that Contribute to p53 Regulation. Mol Cell. 2019 03 21; 73(6):1204-1216.e4. PMID: 30770239.
      View in: PubMed
    31. Tauber D, Parker R. 15-Deoxy-?12,14-prostaglandin J2 promotes phosphorylation of eukaryotic initiation factor 2a and activates the integrated stress response. J Biol Chem. 2019 04 19; 294(16):6344-6352. PMID: 30723157.
      View in: PubMed
    32. Moon SL, Morisaki T, Khong A, Lyon K, Parker R, Stasevich TJ. Multicolour single-molecule tracking of mRNA interactions with RNP granules. Nat Cell Biol. 2019 02; 21(2):162-168. PMID: 30664789.
      View in: PubMed
    33. Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, Johnson AM, Olwin BB, Parker R. TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. Nature. 2018 11; 563(7732):508-513. PMID: 30464263.
      View in: PubMed
    34. Khong A, Parker R. mRNP architecture in translating and stress conditions reveals an ordered pathway of mRNP compaction. J Cell Biol. 2018 12 03; 217(12):4124-4140. PMID: 30322972.
      View in: PubMed
    35. Lester E, Parker R. The Tau of Nuclear-Cytoplasmic Transport. Neuron. 2018 09 05; 99(5):869-871. PMID: 30189205.
      View in: PubMed
    36. Mittag T, Parker R. Multiple Modes of Protein-Protein Interactions Promote RNP Granule Assembly. J Mol Biol. 2018 11 02; 430(23):4636-4649. PMID: 30099026.
      View in: PubMed
    37. Van Treeck B, Parker R. Emerging Roles for Intermolecular RNA-RNA Interactions in RNP Assemblies. Cell. 2018 08 09; 174(4):791-802. PMID: 30096311.
      View in: PubMed
    38. Moon SL, Sonenberg N, Parker R. Neuronal Regulation of eIF2a Function in Health and Neurological Disorders. Trends Mol Med. 2018 06; 24(6):575-589. PMID: 29716790.
      View in: PubMed
    39. Van Treeck B, Protter DSW, Matheny T, Khong A, Link CD, Parker R. RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome. Proc Natl Acad Sci U S A. 2018 03 13; 115(11):2734-2739. PMID: 29483269.
      View in: PubMed
    40. Protter DSW, Rao BS, Van Treeck B, Lin Y, Mizoue L, Rosen MK, Parker R. Intrinsically Disordered Regions Can Contribute Promiscuous Interactions to RNP Granule Assembly. Cell Rep. 2018 02 06; 22(6):1401-1412. PMID: 29425497.
      View in: PubMed
    41. Khong A, Jain S, Matheny T, Wheeler JR, Parker R. Isolation of mammalian stress granule cores for RNA-Seq analysis. Methods. 2018 03 15; 137:49-54. PMID: 29196162.
      View in: PubMed
    42. Khong A, Matheny T, Jain S, Mitchell SF, Wheeler JR, Parker R. The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules. Mol Cell. 2017 Nov 16; 68(4):808-820.e5. PMID: 29129640.
      View in: PubMed
    43. Rao BS, Parker R. Numerous interactions act redundantly to assemble a tunable size of P bodies in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9569-E9578. PMID: 29078371.
      View in: PubMed
    44. Shukla S, Parker R. PARN Modulates Y RNA Stability and Its 3'-End Formation. Mol Cell Biol. 2017 Oct 15; 37(20). PMID: 28760775.
      View in: PubMed
    45. Wheeler JR, Jain S, Khong A, Parker R. Isolation of yeast and mammalian stress granule cores. Methods. 2017 08 15; 126:12-17. PMID: 28457979.
      View in: PubMed
    46. Walters RW, Matheny T, Mizoue LS, Rao BS, Muhlrad D, Parker R. Identification of NAD+ capped mRNAs in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2017 01 17; 114(3):480-485. PMID: 28031484.
      View in: PubMed
    47. Protter DSW, Parker R. Principles and Properties of Stress Granules. Trends Cell Biol. 2016 09; 26(9):668-679. PMID: 27289443.
      View in: PubMed
    48. Shukla S, Parker R. Hypo- and Hyper-Assembly Diseases of RNA-Protein Complexes. Trends Mol Med. 2016 07; 22(7):615-628. PMID: 27263464.
      View in: PubMed
    49. Jain S, Wheeler JR, Walters RW, Agrawal A, Barsic A, Parker R. ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell. 2016 Jan 28; 164(3):487-98. PMID: 26777405.
      View in: PubMed
    50. Mitchell SF, Parker R. Modifications on Translation Initiation. Cell. 2015 Nov 05; 163(4):796-8. PMID: 26544933.
      View in: PubMed
    51. Walters RW, Parker R. Coupling of Ribostasis and Proteostasis: Hsp70 Proteins in mRNA Metabolism. Trends Biochem Sci. 2015 Oct; 40(10):552-559. PMID: 26410596.
      View in: PubMed
    52. Lin Y, Protter DS, Rosen MK, Parker R. Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins. Mol Cell. 2015 Oct 15; 60(2):208-19. PMID: 26412307.
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    53. Schwartz JC, Cech TR, Parker RR. Biochemical Properties and Biological Functions of FET Proteins. Annu Rev Biochem. 2015; 84:355-79. PMID: 25494299.
      View in: PubMed
    54. Lasda E, Parker R. Circular RNAs: diversity of form and function. RNA. 2014 Dec; 20(12):1829-42. PMID: 25404635.
      View in: PubMed
    55. Shukla S, Parker R. Quality control of assembly-defective U1 snRNAs by decapping and 5'-to-3' exonucleolytic digestion. Proc Natl Acad Sci U S A. 2014 Aug 12; 111(32):E3277-86. PMID: 25071210.
      View in: PubMed
    56. Mitchell SF, Parker R. Principles and properties of eukaryotic mRNPs. Mol Cell. 2014 May 22; 54(4):547-58. PMID: 24856220.
      View in: PubMed
    57. Harigaya Y, Parker R. Fragile X mental retardation protein and the ribosome. Mol Cell. 2014 May 08; 54(3):330-2. PMID: 24813710.
      View in: PubMed
    58. Decker CJ, Parker R. Analysis of double-stranded RNA from microbial communities identifies double-stranded RNA virus-like elements. Cell Rep. 2014 May 08; 7(3):898-906. PMID: 24767992.
      View in: PubMed
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